Predictors of opiate agonist treatment retention among injection drug users referred from a needle exchange program

Havens, Jennifer R.; Latkin, Carl A.; Pu, Minya; Cornelius, Llewellyn J.; Bishai, David; Huettner, Steven; Rapp, Charles A.; Ricketts, Erin P.; Lloyd, Jacqueline J.; Strathdee, Steffanie A.

doi:10.1016/j.jsat.2008.07.002

Cited by 35 publications

(27 citation statements)

References 43 publications

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“…A randomised trial of 245 attendees at publically funded MMT in Baltimore corroborates this finding [33]. This is also verified by the current study which revealed that those who are homeless or in unstable housing are more likely to have experienced breaks in MMT.…”

Section: Demographic Factorssupporting

confidence: 88%

Demographic and clinical factors predicting retention in methadone maintenance: results from an Irish cohort

Darker

Kelly

et al. 2015

Ir J Med Sci

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Background Retention in Methadone Maintenance Treatment (MMT) is superior to that of other therapies for opioid addiction, but with international retention rates around 50 % after 1 year of treatment, there remains a need for improved retention rates. Aims This study aimed to explore the demographic and clinical factors predicting retention in MMT. Methods Face-to-face surveys with MMT patients in a Dublin methadone clinic were conducted. Retention was assessed by the presence and duration of breaks in treatment at any stage. Results 189 patients participated in the study. 46 % (n = 87) reported having at least one break in treatment, and the median duration of a break was 3 months. Age, current methadone dose and prescription of antipsychotic medication were significant predictors of retention. Patients who were older, single, living in their own home, on a higher dose of methadone, or taking antipsychotic medications had fewer breaks in treatment. Males tended to have significantly longer breaks. Patients reported that the main reasons for breaks were relapse into drug use (21.8 %, n = 19), incarceration (11.4 %, n = 10), weary of MMT (13.7 %, n = 12) or problems at the clinic (10.3 %, n = 9). Factors enabling regular attendance included wanting to get or stay clean (37.5 %, n = 51), avoidance of withdrawal symptoms (16.1 %, n = 22), methadone dependence (13.9 %, n = 19) and services provided (10.2 %, n = 14). Conclusion Patients who were older, single, living in their own home, on a higher dose of methadone, or taking antipsychotic medications had fewer breaks in treatment.

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Section: Demographic Factorssupporting

confidence: 88%

Demographic and clinical factors predicting retention in methadone maintenance: results from an Irish cohort

Darker

Kelly

et al. 2015

Ir J Med Sci

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“…Familiarity with a medication through prior exposure may encourage preference 13,42,43 . For example, heroin users who chose buprenorphine over methadone (in outpatient treatment), reported that their first hand experiences with using buprenorphine in non-medical contexts (i.e., used for self-management of withdrawal), strongly influenced their choice 42 .…”

Section: Discussionmentioning

confidence: 99%

“…Injection drug users who lived with a partner, family, or friends, were three times more likely to enter OAT than those who lived alone or in non-stable (e.g., streets, abandoned house) or controlled (e.g., transitional housing program), environments 12 . With regard to social network influences, buying drugs for one’s social network at treatment entry strongly predicted early drop-out 13 . Readiness for cessation of drug use was predictive of entry to substance use treatment among injection drug users 14 .…”

Section: Introductionmentioning

confidence: 99%

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Hospitalized opioid‐dependent patients: Exploring predictors of buprenorphine treatment entry and retention after discharge

et al. 2017

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Objectives Few studies have explored predictors of entry into and retention in buprenorphine treatment following linkage from an acute medical hospitalization. Methods This secondary analysis of a completed clinical trial focuses on medically hospitalized, opioid dependent patients (n=72) who were randomized to an intervention including buprenorphine induction and dose stabilization during hospitalization followed by post-discharge transition to office-based buprenorphine treatment (OBOT)). Predictors included demographics, days hospitalized, prior buprenorphine/methadone treatment, PTSD symptoms, social support, and readiness for drug use cessation. Outcome variables were treatment entry and retention (number of days in OBOT). Results Previous buprenorphine treatment, more days hospitalized, and higher PTSD symptoms predicted OBOT entry. Prior treatment, older age, and non-minority status were associated with a higher mean number of days in OBOT. Conclusions OBOT may appeal to patients who have tried buprenorphine in other settings. Linking hospitalized patients to OBOT may improve utilization of addiction treatment. Scientific Significance: Prior substance treatment, longer hospital stay, and mental health should be examined in future linkage studies.

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“…The review by Mattick et al (2003b) showed that fl exible-dose studies had a better outcome than fi xed-dose studies, and a more rapid induction to buprenorphine yielded a better outcome than more gradual induction. Most studies show a lower retention rate in patients with a higher rate of heroin injection or a greater number of previous treatments (Kerr et al 2005;Fischer et al 2008;Soyka et al 2008a;Havens et al 2009). Connock et al (2007) and, more recently, Burns et al (2009) concluded that the mortality rate may be lower in buprenorphine patients than in methadone patients, but these fi ndings were not replicated in another study (Soyka et al 2006.…”

Section: Allocation Of Patients and Predictors Of Outcomementioning

confidence: 99%

The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Substance Use and Related Disorders. Part 2: Opioid dependence

Soyka

Kranzler

Brink

et al. 2011

The World Journal of Biological Psychiatry

114

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Predictors of opiate agonist treatment retention among injection drug users referred from a needle exchange program

Cited by 35 publications

References 43 publications

Demographic and clinical factors predicting retention in methadone maintenance: results from an Irish cohort

Demographic and clinical factors predicting retention in methadone maintenance: results from an Irish cohort

Hospitalized opioid‐dependent patients: Exploring predictors of buprenorphine treatment entry and retention after discharge

The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Substance Use and Related Disorders. Part 2: Opioid dependence

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