Predictors of obstructive sleep apnea in lung transplant recipients

Sommerwerck, Urte; Kleibrink, Bjoern E.; Kruse, Frederike; Scherer, Manuela J.; Wang, Yi; Kamler, Markus; Teschler, Helmut; Weinreich, Gerhard

doi:10.1016/j.sleep.2016.01.005

Cited by 11 publications

(16 citation statements)

References 34 publications

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“…Nevertheless, this latter prevalence is in agreement with the recent estimated prevalence of SDB (15.7%) in the general Belgian population aged between 30 and 69 years 2 . Different studies examined SDB prevalence in LTX patients 9‐11 . SDB prevalence was high in all these studies but pre‐LTX data were not available.…”

Section: Discussionsupporting

confidence: 87%

“…Sommerwerck et al also reported a high prevalence of SDB in LTX patients with underlying COPD and pulmonary fibrosis, but only COPD was a significant independent predictor for SDB 11. Our results confirm the high prevalence of SDB in COPD/emphysema and pulmonary fibrosis patients.…”

supporting

confidence: 87%

“…Most of these studies included a limited number of patients and did not prospectively assess patients at a fixed time interval after LTX 8‐10 . The largest study, evaluating 77 patients, showed a prevalence of 49% 11 . Yet, there is a high variability in reported prevalence.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] The largest study, evaluating 77 patients, showed a prevalence of 49%. 11 Yet, there is a high variability in reported prevalence. Prevalence of SDB after LTX was not significantly increased at 1 month after LTX but was increased at 6 months and 1 year after LTX.…”

mentioning

confidence: 99%

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Sleep-disordered breathing after lung transplantation: An observational cohort study

Testelmans

Schoovaerts

Belge

et al. 2021

American Journal of Transplantation

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Sleep-disordered breathing (SDB) describes a number of disorders, characterized by partial or complete cessation of breathing during sleep, with obstructive sleep apnea (OSA) being the most common form of SDB. SDB prevalence is increasing over the last decades because of increasing prevalence of obesity, improvement in diagnostic methods, and aging of the population. 1 The prevalence of moderate to severe SDB (defined as apnea-hypopnea index ≥ 15/h of sleep) in Belgium is estimated to be 15.7%. 2 Different studies have shown a strong link between the presence of SDB and cardiovascular morbidity and mortality. 3,4 Lung transplantation (LTX) is an effective and important treatment option for selected patients with a variety of end-stage

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Section: Discussionsupporting

confidence: 87%

supporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Sleep-disordered breathing after lung transplantation: An observational cohort study

Testelmans

Schoovaerts

Belge

et al. 2021

American Journal of Transplantation

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“…4,5 Some reports have tried to explore the predictors in order to identify OSA among these patients. [6][7][8] However, most previous cohorts included few patients with advanced lung disease, and the sample size for some studies was small. The relationship between upper airway patency and lung volume has been investigated in some studies, with a reduction in lung volume shown to increase upper airway collapsibility.…”

Section: Introductionmentioning

confidence: 99%

Obstructive Sleep Apnea in Patients With Fibrotic Interstitial Lung Disease and COPD

Zhang

Dai

Zhang

et al. 2019

Journal of Clinical Sleep Medicine

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Study Objectives: Despite the clinical and prognostic significance of obstructive sleep apnea (OSA) in chronic respiratory diseases (CRDs), there have been few studies about the possible predictors of OSA and the effect of OSA on quality of life in patients with CRDs. The objectives were to identify physiological and clinical parameters that predict the occurrence and severity of OSA and to investigate the effect of OSA on quality of life in patients with CRDs. Methods: Seventy-three patients with chronic obstructive pulmonary disease (COPD) and 77 patients with fibrotic interstitial lung disease (ILD) underwent overnight polysomnography (PSG) and pulmonary function testing and completed clinical questionnaires. The oximetry tracing was interpreted blindly with respect to the PSG results. Results: The prevalence of OSA was 44% and 62% in COPD and ILD, respectively. The COPD assessment test item scores related to sleep quality and daily vitality were worse among patients with OSA than among patients without OSA. The STOP-BANG questionnaire (cutoff point ≥ 3) and oxygen desaturation index from the oximetry recording (oxygen desaturation index (ODI) were associated with OSA in CRDs. The STOP-BANG questionnaire with a cutoff point ≥ 3 or 6 had the highest sensitivity and specificity, respectively, in detecting OSA in CRDs. ODI had the best accuracy in identifying OSA and was independently associated with the apnea-hypopnea index in CRDs. Conclusions: We found OSA to be common and associated with worse sleep quality and less daily vitality in patients with advanced CRDs. The STOP-BANG questionnaire with different cutoff points may help rule in or rule out OSA. Overnight oximetry can be used as a screening tool for OSA and can assist the clinical evaluation of OSA in patients with CRDs.

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Influence of Sleep-Disordered Breathing on Quality of Life and Exercise Capacity in Lung Transplant Recipients

Kruse

Kleibrink

Rabis

et al. 2019

Advances in Pulmonary Medicine: Research and Innovations

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Predictors of obstructive sleep apnea in lung transplant recipients

Cited by 11 publications

References 34 publications

Sleep-disordered breathing after lung transplantation: An observational cohort study

Sleep-disordered breathing after lung transplantation: An observational cohort study

Obstructive Sleep Apnea in Patients With Fibrotic Interstitial Lung Disease and COPD

Influence of Sleep-Disordered Breathing on Quality of Life and Exercise Capacity in Lung Transplant Recipients

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