Predictors of obesity hypoventilation syndrome among patients with sleep-disordered breathing in India

Patro, Mahismita; Gothi, Dipti; Ojha, Umesh Chandra; Vaidya, Sameer; Sah, Ram Babu

doi:10.4103/lungindia.lungindia_61_19

Cited by 9 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar finding was observed in a study done by Schreiber et al 20 Higher age is one of the risk factors of OSA in the general population. 21 So, questionnaires like "STOPBang" which GOLD grade 2 GOLD grade 3 GOLD grade 4 COPD-OSA ( 14) COPD (23) p-value COPD-OSA (13) COPD (28) includes high age as risk factors are possibly unreliable screening tools for COPD-OSA overlap syndrome. The lower mean age of COPD-OSA overlap syndrome patients in our study can be explained by the fact that these patients present the syndrome at younger age owing to the severity of symptoms.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Screening Parameters for COPD-OSA Overlap Syndrome in COPD Patients: Indian Perspective

Gothi¹,

Patro²,

Vaidya³

et al. 2023

The Indian Journal of Chest Diseases and Allied Sciences

Self Cite

View full text Add to dashboard Cite

Introduction:As Indian patients have different predisposing morphological characteristics, we undertook this study to evaluate the clinical profile of overlap syndrome and compare them with COPD patients to find out the screening tools for obstructive sleep apnea (OSA) in Indian chronic obstructive pulmonary disease (COPD) patients. Aims and objectives:• To study the clinical profile of patients with overlap syndrome.• To compare them with COPD patients. • To develop screening tools for overlap syndrome in COPD. Materials and methods:A prospective case-control study was carried out in a tertiary care center. Overnight pulse oximetry was carried out for all COPD patients. Those having snoring or saw-tooth pattern on overnight oximetry were subjected to level 1 polysomnography. About 30 patients of overlap syndrome were compared with 65 COPD patients. Results: The mean age in overlap syndrome group (56.9 ± 6.86 years) was significantly lower (p < 0.01). The daytime PaO 2 and lowest nocturnal saturation were significantly lower in overlap group. PaCO 2 and forced expiratory volume at 1 second (FEV1) were significantly higher. For diagnosing overlap syndrome, the positive and the negative predictive values of snoring were 84.42 and 100%; of body mass index (BMI) ≥25 kg/m 2 were 86.67 and 98.88%; and of excessive daytime sleepiness were 37.57 and 97.86%, respectively. Conclusion: Absence of snoring and BMI <25 kg/m 2 virtually rules out overlap syndrome. The EDS has a high false-positive rate for predicting OSA. Patients having overlap syndrome have poor daytime and nocturnal oxygenation despite good lung functions.

show abstract

Section: Discussionmentioning

confidence: 99%

“…They found that the Asian patients with OSA had lower BMI and different cephalometric parameters. [26][27][28] Patients with OSA commonly have EDS. But EDS cannot be taken as a predictor of OSA in COPD.…”

Section: Discussionmentioning

confidence: 99%

Screening Parameters for COPD-OSA Overlap Syndrome in COPD Patients: Indian Perspective

Gothi¹,

Patro²,

Vaidya³

et al. 2023

The Indian Journal of Chest Diseases and Allied Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…Japanese individuals with OHS tend to be younger than OSA patients [ 41 , 42 ], while in the Middle East, OHS patients appear to be older than OSA patients [ 43 , 44 ]. East Asian [ 45 ] and Indian [ 46 ] populations tend to develop OHS at lower BMIs than non-Asian populations. Reflecting upon these ethnic differences, S aeseow et al .…”

Section: Serum Bicarbonatementioning

confidence: 99%

Defining obesity hypoventilation syndrome

Shah

Shrimanker

Kaltsakas

2021

Breathe

View full text Add to dashboard Cite

With increasing prevalence of obesity, the substantial contribution of obesity hypoventilation syndrome (OHS) to morbidity and mortality is likely to increase. It is therefore crucial that the condition has a clear definition to allow timely identification of patients. OHS was first described as “Pickwickian syndrome” in the 1950s; in subsequent decades, case reports did not clearly delineate between patients suffering from OHS and those suffering from obstructive sleep apnoea. In 1999, the American Academy of Sleep Medicine published a guideline that delineated the cause of daytime hypercapnia as either predominantly upper airway or predominantly hypoventilation. This was the first formal definition of OHS as the presence of daytime alveolar hypoventilation (arterial carbon dioxide tension >45 mmHg) in patients with body mass index >30 kg·m−2 in the absence of other causes of hypoventilation. This definition is reflected in the most recent guidelines published on OHS. Recent developments in defining OHS include proposed classification systems of severity and demonstrating the value of using serum bicarbonate to exclude OHS in patients with a low index of suspicion.Educational aimsTo provide an overview of the historical basis of the definition of obesity hypoventilation syndrome.To explain the rationale for the current definition of obesity hypoventilation syndrome.To demonstrate areas that need further investigation in defining obesity hypoventilation syndrome.

show abstract

“…Obesity and a family reduced response to hypercapnia are likely two distinct causes of respiratory failure in the child with obesityhypoventilation syndrome. Only a tiny number of obese patients experience the obesity-hypoventilation syndrome, which may be explained by the hereditary aspect [10][11][12]. Although the obesity-hypoventilation syndrome in children is uncommon, it can have catastrophic consequences and has a high death rate.…”

Section: Introductionmentioning

confidence: 99%

Overview on Pediatric Obesity Hypoventilation Syndrome

Fadl,

Mashael Abdulaziz Shahatah,

Atheer Yahya S Asiri

et al. 2023

SMHJ

View full text Add to dashboard Cite

The relationship between obesity and the onset of persistent daytime alveolar hypoventilation is known as obesity hypoventilation syndrome. This illness results from a complicated interaction between sleep-disordered breathing, reduced respiratory drive, and obesity-related respiratory impairment, and is associated with considerable morbidity and mortality. Extreme obesity has become far more common in the United States and other nations during the past three decades. The prevalence of OHS will inevitably rise considering the global obesity pandemic. When compared to people with sleep apnea, patients with OHS have a poorer quality of life, incur higher medical costs, and are more likely to develop pulmonary hypertension and die young. Even though this illness is associated with severe morbidity and mortality, it is commonly overlooked, and treatment is typically postponed. Clinicians need to keep a high index of suspicion since this syndrome carries a heavy burden of morbidity and mortality, which is reduced by early diagnosis and treatment. The definition and clinical presentation of OHS, a brief overview of its prevalence, a review of current understanding of pathophysiology, and discussion of recent developments in therapeutics will all be included in this review.

show abstract

Predictors of obesity hypoventilation syndrome among patients with sleep-disordered breathing in India

Cited by 9 publications

References 28 publications

Screening Parameters for COPD-OSA Overlap Syndrome in COPD Patients: Indian Perspective

Screening Parameters for COPD-OSA Overlap Syndrome in COPD Patients: Indian Perspective

Defining obesity hypoventilation syndrome

Overview on Pediatric Obesity Hypoventilation Syndrome

Contact Info

Product

Resources

About