Predictors of Nosocomial Bloodstream Infections in Older Adults

Kaye, Keith S.; Marchaim, Dror; Chen, Ting Yi; Chopra, Teena; Anderson, Deverick J.; Choi, Yujung; Sloane, Richard; Schmader, Kenneth E.

doi:10.1111/j.1532-5415.2010.03289.x

Cited by 51 publications

(34 citation statements)

References 39 publications

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“…With regard to specific infection sites, the present study demonstrates that obesity class I–III patients with cirrhosis have higher prevalence of bacteraemia, UTI and skin and soft tissue infection than non‐obese patients with cirrhosis. Our data regarding bacteraemia and UTI prevalence are consistent with evidence from prior studies of obese individuals in the general population, although ours is the first to corroborate this in the cirrhotic population . Our analysis additionally shows that obese patients have a lower prevalence of SBP compared to non‐obese individuals.…”

Section: Discussionsupporting

confidence: 91%

Obesity is independently associated with infection in hospitalised patients with end‐stage liver disease

Sundaram

Kaung

Rajaram

et al. 2015

Aliment Pharmacol Ther

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Summary Background Infection is the most common cause of mortality in end‐stage liver disease (ESLD). The impact of obesity on infection risk in ESLD is not established. Aim To characterise the impact of obesity on infection risk in ESLD. Methods We evaluated the association between infection and obesity in patients with ESLD. Patients grouped as non‐obese, obesity class I–II and obesity class III were studied using the Nationwide Inpatient Sample. Validated diagnostic code based algorithms were utilised to determine weight category and infections, including bacteraemia, skin/soft tissue infection, urinary tract infection (UTI), pneumonia/respiratory infection, Clostridium difficile infection (CDI) and spontaneous bacterial peritonitis (SBP). Risk factors for infection and mortality were assessed using multivariable logistic regression analysis. Results Of 115 465 patients identified, 100 957 (87.5%) were non‐obese and 14 508 (12.5%) were obese, with 9489 (8.2%) as obesity class I–II and 5019 (4.3%) as obesity class III. 37 117 patients (32.1%) had an infection diagnosis. Infection was most prevalent among obesity class III (44.0%), followed by obesity class I–II (38.9%) and then non‐obese (31.9%). In multivariable modelling, class III obesity (OR = 1.41; 95% CI 1.32–1.51; P < 0.001), and class I–II obesity (OR = 1.08; 95% CI 1.01–1.15; P = 0.026) were associated with infection. Compared to non‐obese patients, obese individuals had greater prevalence of bacteraemia, UTI, and skin/soft tissue infection as compared to non‐obese patients. Conclusions Obesity is newly identified to be independently associated with infection in end‐stage liver disease. The distribution of infection sites varies based on weight category.

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Section: Discussionsupporting

confidence: 91%

Obesity is independently associated with infection in hospitalised patients with end‐stage liver disease

Sundaram

Kaung

Rajaram

et al. 2015

Aliment Pharmacol Ther

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“…A retrospective study showed that obesity is an independent predictor of blood stream infection. 7 Other previous studies have shown a correlation between obesity and septic shock, ventilator-associated pneumonia, 8 catheter-associated sepsis, 9 H1N1 influenza infection, 10 and Clostridium difficile infection. 11 Moreover, obesity may alter the course of infection and seems to contribute to the progression of some chronic viral infections such as hepatitis C. [12][13][14] Urinary tract infection (UTI) is one of the most commonly acquired bacterial infections in ambulatory and hospitalized populations.…”

Section: Introductionmentioning

confidence: 90%

Obesity and recurrent urinary tract infections in premenopausal women: a retrospective study

Nseir

Farah

Mahamid

et al. 2015

International Journal of Infectious Diseases

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“…53 Cohort studies indicate an association between obesity and the risk of nosocomial infections. 12,54 A recent retrospective case-control study has shown obesity to be an independent predictor of nosocomial bloodstream infection in older adults. 54…”

Section: Nosocomial Infections and Surgical Infectionsmentioning

confidence: 99%

“…12,54 A recent retrospective case-control study has shown obesity to be an independent predictor of nosocomial bloodstream infection in older adults. 54…”

Section: Nosocomial Infections and Surgical Infectionsmentioning

confidence: 99%

Obesity and the risk and outcome of infection

2012

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The interactions between obesity and infectious diseases have recently received increasing recognition as emerging data have indicated an association between obesity and poor outcome in pandemic H1N1 influenza infection. Obesity is an established risk factor for surgical-site infections, nosocomial infections, periodontitis and skin infections. Several studies indicate that acute pancreatitis is more severe in the obese. Data are controversial and limited as regards the association between obesity and the risk and outcome of community-acquired infections such as pneumonia, bacteremia and sepsis and obesity and the course of HIV infection. As the cause-effect relationship between obesity and infection remains obscure in many infectious diseases, further studies are warranted. The consequences of obesity may have substantial effects on the global burden of infectious diseases.

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Predictors of Nosocomial Bloodstream Infections in Older Adults

Cited by 51 publications

References 39 publications

Obesity is independently associated with infection in hospitalised patients with end‐stage liver disease

Obesity is independently associated with infection in hospitalised patients with end‐stage liver disease

Obesity and recurrent urinary tract infections in premenopausal women: a retrospective study

Obesity and the risk and outcome of infection

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