Predictors of nodal metastasis in salivary gland cancer

Korkmaz, Hakan; Yoo, George H.; Du, Wei; Hocwald, Eitan; Otero-Garcia, Jose E.; Adsay, Volkan; Shibuya, Terry Y.; Jacobs, John R.

doi:10.1002/jso.10125

Cited by 30 publications

(16 citation statements)

References 12 publications

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“…The corresponding rates for patients with submandibular gland cancer are 41 and 9%, respectively [2,3] . Similar differences in the 5-and 10-year overall survival rates have been reported more recently [4,5] . Therefore, appropriate management of the regional lymph nodes is important in the treatment of patients with carcinoma of the major salivary glands.…”

Section: Introductionsupporting

confidence: 69%

“…In many of these cases, the first echelon is represented by the intraparotid lymph nodes. The mean numbers of intraparotid lymph nodes that have been reported are 7 (range, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] in the superficial lobe and 2 (range, 0-9) in the deep lobe [38] . Furthermore, a statistically significant correlation (p = 0.005) has been observed between the presence of intraparotid metastatic nodes and neck node metastases [39] .…”

Section: Sentinel Node Biopsy In Primary Parotid Cancermentioning

confidence: 99%

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Management of Regional Metastases of Malignant Salivary Gland Neoplasms

Medina¹,

Zbären

Bradley

2016

Salivary Gland Neoplasms

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Metastases from salivary gland carcinomas to the cervical lymph nodes are relatively uncommon. However, their impact on prognosis is significant and, thus, it is important to manage them appropriately. Treatment of clinically evident metastases consists primarily of surgery, frequently followed by radiation. Management of the N0 neck, on the other hand, remains controversial. While there seems to be agreement regarding the tumor and patient factors that make it more likely for a patient to harbor subclinical metastases in the lymph nodes, some clinicians prefer to treat those patients with surgery, i.e. a neck dissection, and others prefer to use elective radiation. These different approaches and their rationale will be discussed in detail.

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Section: Introductionsupporting

confidence: 69%

Section: Sentinel Node Biopsy In Primary Parotid Cancermentioning

confidence: 99%

Management of Regional Metastases of Malignant Salivary Gland Neoplasms

Medina¹,

Zbären

Bradley

2016

Salivary Gland Neoplasms

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“…However, if malignancy is suspected, neck dissection is occasionally considered in pre-operative planning. A number of factors, including advanced tumor stages and extracapsular invasions, are considered to determine whether neck dissection is necessary, but malignancy remains the fundamental factor when considering neck dissection (15–18). …”

Section: Discussionmentioning

confidence: 99%

Salivary gland tumors: A 20-year review of clinical diagnostic accuracy at a single center

et al. 2013

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Obtaining reliable pre-operative diagnosis is crucial in planning treatment for patients with salivary gland tumors. The purpose of this study was to evaluate the accuracy of pre-operative clinical diagnosis of salivary gland tumors managed at a single tertiary university hospital over a period of 20 years. A retrospective analysis of the period between 1992 and 2011 was carried out to review the cases of patients with salivary gland tumors. A total of 101 patients were enrolled and general data were described. Clinical diagnosis was compared with the final pathological diagnosis to reveal the clinical diagnostic accuracy. Of the parotid and submandibular gland tumors, 86 and 67% were benign, respectively. The clinical diagnostic accuracies for diagnosis of parotid tumors as benign or malignant were 100 and 57%, respectively. The clinical diagnostic accuracies for diagnosis of submandibular tumors as benign or malignant were 67%. Therefore, the overall clinical judgment of benign and malignant tumors in the submandibular gland is unreliable. The accuracy for a parotid tumor to be clinically interpreted as benign was 100%. While it is difficult to draw any conclusion for non-parotid gland tumors, surgical intervention should be recommended in patients with parotid tumors clinically suspected to be malignant, and all submandibular, sublingual and minor salivary gland tumors.

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“…[37, 38] Elective neck dissection (END) should be indicated when the risk of subclinical disease in a clinically negative neck exceeds 15%. [36] Hence, it would be of great value to formulate a criteria to select patients for whom a neck dissection should be incorporated into the surgical management of the primary tumor.…”

Section: Elective Neck Dissectionmentioning

confidence: 99%

Management of salivary gland carcinomas - a review

et al. 2016

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Salivary gland carcinomas are a heterogeneous group of tumors with many histological subtypes which occur in both major and minor salivary glands. However, they have a relatively low of incidence. Their rarity limits study size and the ability to perform phase III trials. Therefore, to date, the entire management is usually varied. Certain published studies have paid more attention to the systemic therapy in the management of metastatic or locally recurrent salivary gland cancer, while little effort has been made to study the entire management for this lesions. Although results of treatment for patients with salivary gland carcinoma have improved in recent years, the treatment of salivary gland cancers is still not standardized. And some patients who haven’t received optimal treatment strategies had a reduced survival. In this review, the topics covered include surgery and radiotherapy, selective neck dissection, chemotherapy, and targeted therapy, which aimed to summarize the optimal management approaches and to develop recommendations for managing this lesions. For these rare cancers, there is also a need for a determined, coordinated effort to conduct high-quality clinical trials.

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Predictors of nodal metastasis in salivary gland cancer

Abstract: Our results suggest that clinical neck examination is a reliable predictor of regional metastasis in patients with major salivary gland cancer. In view of the low frequency of occult metastases, routine elective treatment of the neck is not recommended.

Cited by 30 publications

References 12 publications

Management of Regional Metastases of Malignant Salivary Gland Neoplasms

Management of Regional Metastases of Malignant Salivary Gland Neoplasms

Salivary gland tumors: A 20-year review of clinical diagnostic accuracy at a single center

Management of salivary gland carcinomas - a review

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