Predictors of NIV Treatment in Patients with COPD Exacerbation Complicated by Respiratory Acidaemia

Echevarria, Carlos; Steer, John; Hartley, Tom; Lane, Nicholas D.; Bourke, Stephen

doi:10.1080/15412555.2020.1823358

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…The World Health Organization (WHO) reported that COPD is the third leading cause of death worldwide, with 3 million deaths in 2019, and is responsible for 6% of total global deaths, after ischemic heart disease and stroke [5]. While COPD is not currently curable, its symptoms can be effectively managed through medical therapies [6]. Therefore, effective treatment of COPD is necessary concerning the causative factors and pathology of COPD [7].…”

Section: Introductionmentioning

confidence: 99%

Rice Bran Oil Improves Emphysema in Cigarette Smoke Extract-Induced Mice through Anti-Inflammatory and Antioxidative Effects

Kettawan,

Ruangklai,

Rungruang

et al. 2024

Nutrients

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Lung inflammation and alveolar enlargement are the major pathological conditions of chronic obstructive pulmonary disease (COPD) patients. Rice bran oil (RBO), a natural anti-inflammatory and antioxidative agent, has been used for therapeutic purposes in several inflammatory diseases. This study aimed to investigate the anti-inflammatory and antioxidative effect of RBO on a cigarette smoke extract (CSE)-induced emphysema model in mice. The results indicated that CSE significantly induced airspace enlargement in mouse lung. Increased inflammatory cells, macrophage, and TNF-alpha levels in bronchoalveolar lavage fluid (BALF) were noticed in CSE-treated mice. RBO (low and high dose)-supplemented mice showed decreased total BALF inflammatory cell, macrophage, and neutrophil numbers and TNF-alpha levels (p < 0.05). Additionally, the administration of RBO decreased the mean linear alveolar intercept (MLI) in the CSE-treated group. Additionally, RBO treatment significantly increased the total antioxidant capacity in both mouse BALF and serum. However, RBO did not have an effect on the malondialdehyde (MDA) level. These findings suggested that RBO treatment ameliorates lung inflammation in a CSE-induced emphysema mice model through anti-inflammatory and antioxidant pathways. Therefore, the supplementation of RBO could be a new potential therapeutic to relieve the severity of COPD.

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Section: Introductionmentioning

confidence: 99%