Predictors of neurobehavioral symptom reporting in a community based sample with mild traumatic brain injury

Esterov, Dmitry; Lennon, Ryan J.; Bergquist, Thomas F.; Brown, Allen W.

doi:10.3233/nre-203082

Cited by 7 publications

(3 citation statements)

References 65 publications

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“…Individuals who have endured mTBI, and particularly those with rmTBI, often have concomitant long-term neurological symptoms, including a decline in cognition, motor abilities and changes in behavior [81][82][83][84][85]. Extensive neuropsychological testing procedures have been established to evaluate the long-term effects, which include clinical assessments, as well as self-administered questionnaires, such as NSI-22 and PHQ-9 [86][87][88]. We conducted a secondary analysis of the psychological symptom burden in the LIMBIC CENC cohort to evaluate whether the levels of the four serum lncRNAs (VLDLR-AS1, MALAT1, NEAT1, GAS5) correlate to symptom burden (such as cognition, memory, depression or PTSD) after rmTBI.…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans

Patel,

Krause-Hauch,

Kenney

et al. 2024

IJMS

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More than 75% of traumatic brain injuries (TBIs) are mild (mTBI) and military service members often experience repeated combat-related mTBI. The chronic comorbidities concomitant with repetitive mTBI (rmTBI) include depression, post-traumatic stress disorder or neurological dysfunction. This study sought to determine a long noncoding RNA (lncRNA) expression signature in serum samples that correlated with rmTBI years after the incidences. Serum samples were obtained from Long-Term Impact of Military-Relevant Brain-Injury Consortium Chronic Effects of Neurotrauma Consortium (LIMBIC CENC) repository, from participants unexposed to TBI or who had rmTBI. Four lncRNAs were identified as consistently present in all samples, as detected via droplet digital PCR and packaged in exosomes enriched for CNS origin. The results, using qPCR, demonstrated that the lncRNA VLDLR-AS1 levels were significantly lower among individuals with rmTBI compared to those with no lifetime TBI. ROC analysis determined an AUC of 0.74 (95% CI: 0.6124 to 0.8741; p = 0.0012). The optimal cutoff for VLDLR-AS1 was ≤153.8 ng. A secondary analysis of clinical data from LIMBIC CENC was conducted to evaluate the psychological symptom burden, and the results show that lncRNAs VLDLR-AS1 and MALAT1 are correlated with symptoms of depression. In conclusion, lncRNA VLDLR-AS1 may serve as a blood biomarker for identifying chronic rmTBI and depression in patients.

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Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans

Patel,

Krause-Hauch,

Kenney

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Why do some individuals with an MTBI have a minimal and short-lasting set of symptoms while others may experience intractable, long-lasting and significantly disabling consequences? In a group of 80 individuals in outpatient rehabilitation treatment for symptoms associated with MTBI, Esterov et al (2020) generate a multivariate analysis linking a variety of potential predictor variables to the Neurobehavioral Symptom Inventory that documents the ongoing symptoms the patients are experiencing and reporting. The findings support the idea that it is not the direct effects of the injury that are neces-sarily the dominant factor in the development of associated disability, but rather how the person is coping with the socially dislocating effects of the injury-for example, the impact on the ability to participate in community functions.…”

Section: Introduction To Contributed Papersmentioning

confidence: 99%

Introduction to the thematic issue on stress, pain and the brain

Goldberg

Eapen

Kamen

2020

NRE

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“…2,3 Despite the high incidence of concussion and possible consequences associated with these injuries, athletes underreport concussions, which may lead to delays in treatment and recovery, an increased risk of future concussions, and worse outcomes. [4][5][6][7][8][9][10] Increasing youth awareness, knowledge, and reporting norms can promote prevention, enhance recovery, and benefit public health. 9,11,12 Researchers [13][14][15][16][17][18][19][20] have evaluated the efficacy of available concussion-education materials using the theory of planned behavior (TPB).…”

mentioning

confidence: 99%

Evaluating the Effect of Concussion-Education Programs on Intent to Report Concussion in High School Football

Daneshvar

Yutsis

Baugh

et al. 2021

Journal of Athletic Training

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Context Concussion underreporting leads to delays in diagnosis and treatment, prolonging recovery time. Athletes' self-reporting of concussion symptoms, therefore, reduces risk. Objective To evaluate the effectiveness of 3 concussion-education programs in improving concussion-reporting intention. Design Randomized controlled clinical trial. Setting Three high schools in California. Patients or Other Participants A total of 118 male football players (age = 14.88 ± 1.19 years). Intervention(s) Participants were randomly assigned to receive concussion education via CrashCourse (CC), Centers for Disease Control and Prevention (CDC) video education materials (CDC-Vi), or CDC written education materials (CDC-Wr). Main Outcome Measure(s) The primary outcome was concussion-reporting intention, which was assessed at baseline, immediately after education, and at 1-month follow-up. Secondary outcomes were concussion knowledge, concussion-reporting attitudes, perceived concussion-reporting norms, and perceived behavioral control. Results Across all education formats, a total sample of athletes improved in concussion-reporting intention at immediate and 1-month follow-ups (mean improvements = 6.8% and 11.4%, respectively; F4,224 = 11.1, P < .001). Similar findings were observed across all education formats in secondary analyses examining knowledge, attitudes, and perceived behavioral control. However, we noted differences in concussion-reporting intention by education format and time (F4,224 = 2.8, P = .03). Post hoc analysis showed that athletes who received CC had increased concussion-reporting intentions at immediate and 1-month follow-ups (baseline = 4.7, immediate follow-up = 6.1, 1-month follow-up = 6.0; F16,61.1 = 6.1, P = .007) compared with increases only at 1-month follow-up for CDC-Vi (baseline = 4.3, immediate follow-up = 5.2, 1-month follow-up = 5.8; F1.6,61.6 = 8.4, P = .001) and no improvement for CDC-Wr (P = .10). Secondary analyses indicated differences between CC and both CDC interventions in concussion knowledge and attitudes at immediate and 1-month follow-ups. We identified no differences in perceived behavioral control among interventions (F4,216 = 0.2, P = .93) or perceived concussion-reporting norms across (F4,224 = 0.3, P = .73) or among (F4,224 = 1.7, P = .15) interventions. Conclusions All athletes exhibited an improved intent to report concussions, increased concussion knowledge, better concussion attitudes, and more perceived behavioral control at both immediate and 1-month follow-ups. However, athletes randomized to receive CC reported a greater intent to report concussion, more knowledge, and improved concussion-reporting attitudes when compared with those who received CDC-Vi and CDC-Wr.

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Predictors of neurobehavioral symptom reporting in a community based sample with mild traumatic brain injury

Cited by 7 publications

References 65 publications

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans

Introduction to the thematic issue on stress, pain and the brain

Evaluating the Effect of Concussion-Education Programs on Intent to Report Concussion in High School Football

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