Predictors of multidrug resistance among pulmonary tuberculosis patients in a tertiary hospital in North Sumatera, Indonesia

Kusumawati, R. Lia; Tania, Tryna; McNeil, Edward; Chongsuvivatwong, Virasakdi

doi:10.15562/bmj.v7i1.813

Cited by 7 publications

(5 citation statements)

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“…Moreover, treatment of MDR-TB is more delicate, more toxic, more expensive, and ineffective than the remedy of patients contaminated by susceptible strains. 5 Metabolism and excretion are the processes of removing an administered drug from the body. The main organ of metabolism is the liver (xenobiotic metabolism), and the organ primarily tasked with excretion is the kidney, although many metabolisms and excretion sites exist.…”

Section: Artikel Penelitianmentioning

confidence: 99%

“…4 Bacteria of M. tuberculosis against the kinds of first-line drug treatments such as rifampicin and isoniazid called multidrug-resistant tuberculosis (MDR-TB). 5 New and previously treated TB cases have been tested for resistance to rifampicin and reported globally, approximately 30% (2.0 million) of the 6.7 million in 2017. There were 24% for new TB patients, and 160.684 cases of multidrug-resistant TB and rifampicinresistant TB (MDR/RR-TB) were notified globally.…”

Section: Introductionmentioning

confidence: 99%

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Association of Multidrug-Resistant Tuberculosis (MDR-TB) Patients on Profile of Liver and Kidney Function

Muda,

Adam,

Saputra

et al. 2023

JKPBK

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Introduction: Therapy of multidrug-resistant tuberculosis (MDR-TB) patients is still not handled properly, is more toxic, and is more high-priced. The liver is the primary metabolism, and the kidney is the main excretion organ. The study aims to know the association of multidrug-resistant tuberculosis (MDR-TB) patients on profile of liver and kidney function Methods: The research is a cross-sectional study with consecutive sampling. Twenty-four respondents were confirmed as MDR-TB patients without HIV who had done biochemical tests. Results: We found that sex of MDR-TB patients on liver function; ALT (p = 0.124) and AST (p = 0.077) and kidney function; BUN (p = 0.270), creatinine (p = 0.137). Age of MDR-TB patients on liver function; ALT (p = 0.587) and AST (p = 0.093) and kidney function; BUN (p = 0.423), creatinine (p = 0.142). Comorbid on MDR-TB patients on liver function; ALT (p = 0.756) and AST (p = 0.244) and kidney function; BUN (p = 0.816), creatinine (p = 0.612). Conclusions: There were no association in sex, age, and comorbid of MDR-TB on liver and kidney function.

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Section: Artikel Penelitianmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Multidrug-Resistant Tuberculosis (MDR-TB) Patients on Profile of Liver and Kidney Function

Muda,

Adam,

Saputra

et al. 2023

JKPBK

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“…Hal ini terkait dengan tingginya jumlah bakteri pada pasien dengan kavitas paru yang menyebabkan lebih banyak jumlah kuman yang dapat dorman terutama pada wilayah apeks paru yang memiliki tekanan oksigen tinggi. 8,19 Studi ini terbatas dalam hal jumlah sampel, dimana masih sedikitnya jumlah pasien TB relapse yang terdiagnosis, kurang baiknya penyimpanan rekam medis dan terbatasnya waktu untuk penelitian menyebabkan jumlah sampel yang dapat diakses dalam studi ini menjadi terbatas. Studi ini juga menggunakan desain deskriptif dimana tidak dilakukan analisa antara variabel sehingga tidak dapat diketahui faktor risiko yang dapat meningkatkan kejadian relapse pada TB paru.…”

Section: Karakteristik Gambaran Foto Rontgen Thoraks Pasien Tb Paru Runclassified

Karakteristik penderita tuberkulosis paru relapse yang berobat di poli paru RSUP Sanglah Denpasar Bali periode Mei 2017 hingga September 2018

Widyastuti

Bagiada

Andrika

2019

Intisari Sains Medis

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Introduction: Relapse pulmonary tuberculosis (TB) is a TB patient who has previously received TB treatment, and has been declared cured or complete treatment, was re-diagnosed with positive smear TB based on swab examination or culture. In Indonesia there are many cases of repeat treatment. 70% of them are relapse cases. So that research on the characteristics of pulmonary TB patients relapse is important. Method: This research is a cross sectional descriptive study where the source of the data comes from secondary data, namely medical records of patients with pulmonary TB patients relapse in pulmonary outpatient clinics at Sanglah General Hospital period May 2017 until September 2018. Result: The results of this study showed that there were 40 patients proven to have pulmonary TB relapse. Most of the patients have ages of 50 to 59 years (25.0%), male sex (55.0%), last education in high school (57.5%), as many as 27.5% of them work as entrepreneurs and 27.5% do not work , the range of BMI in relapse pulmonary TB patients is 13-31 kg / m2 to 28.04 kg / m2 with an average of 19.54 + 3.03 kg / m2, the most clinical complaints are cough (80%), the most common comorbidities are pneumonia (15%) and based on thorax X-ray results found that the most finding was a picture of pleural effusion (22.5%). Conclusion: Based on demographic characteristics, relapse pulmonary TB patients were dominated by age + 50 years with male sex, highschool education status, dominant in patients who did not work and had a low BMI. Based on clinical symptoms, coughing up phlegm, coughing up bleeding and chest tightness are common symptoms. Based on the accompanying comorbidities, pneumonia and heart failure that most often accompanying disease. The most common X-ray image found in relapse pulmonary TB patients is the presence of pleural effusion.

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“…In the provinces of North Sumatra and West Sumatra, where our study was based, the services for DR-TB are more readily available in North Sumatra than in West Sumatra. For culture and drug sensitivity testing, there is only one L3 hospital (Adam Malik Hospital) in Medan in North Sumatra [ 16 ]. Furthermore, 17 hospitals of DR-TB treatment centers are available in North Sumatra compared with only 4 hospitals in West Sumatra.…”

Section: Introductionmentioning

confidence: 99%

Missing Cases of Bacteriologically Confirmed TB/DR-TB from the National Treatment Registers in West and North Sumatra Provinces, Indonesia

et al. 2023

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This study aimed to assess the percentage of confirmed drug-sensitive (DS) TB and drug-resistant (DR) TB patients who were missing in the national treatment registration in North Sumatra and West Sumatra, where treatment services for DR-TB in North Sumatra are relatively well established compared with West Sumatra, where the system recently started. Confirmed DS/DR-TB records in the laboratory register at 40 government health facilities in 2017 and 2018 were traced to determine whether they were in the treatment register databases. A Jaro–Winkler soundexed string distance analysis enhanced by socio-demographic information matching had sensitivity and specificity over 98% in identifying the same person in the same or different databases. The laboratory data contained 5885 newly diagnosed records of bacteriologically confirmed TB cases. Of the 5885 cases, 1424 of 5353 (26.6%) DS-TB cases and 133 of 532 (25.0%) DR-TB cases were missing in the treatment notification database. The odds of missing treatment for DS-TB was similar for both provinces (AOR = 1.0 (0.9, 1.2), but for DR-TB, North Sumatra had a significantly lower missing odds ratio (AOR = 0.4 (0.2, 0.7). The system must be improved to reduce this missing rate, especially for DR-TB in West Sumatra.

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Predictors of multidrug resistance among pulmonary tuberculosis patients in a tertiary hospital in North Sumatera, Indonesia

Cited by 7 publications

References 0 publications

Association of Multidrug-Resistant Tuberculosis (MDR-TB) Patients on Profile of Liver and Kidney Function

Association of Multidrug-Resistant Tuberculosis (MDR-TB) Patients on Profile of Liver and Kidney Function

Karakteristik penderita tuberkulosis paru relapse yang berobat di poli paru RSUP Sanglah Denpasar Bali periode Mei 2017 hingga September 2018

Missing Cases of Bacteriologically Confirmed TB/DR-TB from the National Treatment Registers in West and North Sumatra Provinces, Indonesia

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