Predictors of mortality within three months in the patients with malignant pleural effusion

Özyurtkan, Mehmet Oğuzhan; Balcı, Akın Eraslan; Çakmak, Muharrem

doi:10.1016/j.ejim.2009.09.012

Cited by 48 publications

(33 citation statements)

References 17 publications

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“…An increased concentration of vascular endothelial growth factor (VEGF), which is mainly secreted from endothelial cells is also detected in MPE (12). Certain biochemical properties of pleural effusion, including glucose and total protein concentration, may predict mortality in patients with MPE (13). Interferon γ (IFNG) and transforming growth factor β (TGFB) 1 are associated with tuberculosis pleural effusion, but not MPE (14,15).…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion

Chang

Liu

et al. 2017

Oncology Letters

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Abstract. Pleural effusion is associated with multiple benign and malignant conditions. Currently no biomarkers differentiate malignant pleural effusion (MPE) and benign pleural effusion (BPE) sensitively and specifically. The present study identified a novel combination of biomarkers in pleural effusion for differentiating MPE from BPE by enrolling 75 patients, 34 with BPE and 41 with MPE. The levels of lactate dehydrogenase, glucose, protein, and total cell, neutrophil, monocyte and lymphocyte counts in the pleural effusion were measured. The concentrations of interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor-α, interferon γ, transforming growth factor-β1, colony stimulating factor 2, monocyte chemoattractant protein-1 and vascular endothelial growth factor (VEGF) were detected using cytometric bead arrays. Protein and VEGF levels differed significantly between patients with BPE and those with MPE. The optimal cutoff value of VEGF and protein was 214 pg/ml and 3.35 g/dl respectively, according to the receiver operating characteristic curve. A combination of VEGF >214 pg/ml and protein >3.35 g/dl in pleural effusion presented a sensitivity of 92.6% and an accuracy of 78.6% for MPE, but was not associated with a decreased survival rate. These results suggested that this novel combination strategy may provide useful biomarkers for predicting MPE and facilitating early diagnosis.

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Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion

Chang

Liu

et al. 2017

Oncology Letters

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“…Low pH, low glucose or elevated LDH are considered by many authors to correlate with poor prognosis, 1,3,5,6 although survival is much more strongly related to tumor histology. 7 In a systematic review Heffner et al 2 affirms a greater relationship between low pH and pleurodesis failure compared with low pH and shorter survival time. Regarding the variable Karnofsky index, and in contrast to other authors, 7,8 we found no relation with survival using a cut-off of 70.…”

Section: Methodsmentioning

confidence: 99%

“…7 In a systematic review Heffner et al 2 affirms a greater relationship between low pH and pleurodesis failure compared with low pH and shorter survival time. Regarding the variable Karnofsky index, and in contrast to other authors, 7,8 we found no relation with survival using a cut-off of 70. On the other hand, comorbidity based on the Charlson index strongly predicted prognosis.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3] The current TNM classification of lung cancer has re-classified patients with metastasis, discriminating those having only pleural involvement from those with distant metastasis, as prognosis and survival differences exist between these two groups. 4 Biochemical characteristics of pleural fluid [5][6][7] and comorbidity 8 are also related to survival. However, studies are scarce and therefore clinical guidelines are inconclusive [1][2][3] to establish which factors influence prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of aberrant hypermethylation in pleural effusion of lung adenocarcinoma

Botana-Rial

Chiara

Valverde

et al. 2012

Cancer Biology & Therapy

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“…A number of factors may help predict the survival of these patients, including tumor characteristics, comorbidities, and the composition of the effusion 4, 5, 6, 7. Prognostic evaluation of survival of patients undergoing video‐assisted thoracic surgery (VATS) talc pleurodesis for MPE may help individualize treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Predictors of survival in patients who underwent video‐assisted thoracic surgery talc pleurodesis for malignant pleural effusion

et al. 2016

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BackgroundPatients with malignant pleural effusion have a limited life expectancy. An increase in pleural and oncological treatment options and more accurate prognostic evaluation may help individualize treatment strategies. The aim of this study was to identify the prognostic indicators of overall survival (OS) after video‐assisted thoracic surgery (VATS) talc pleurodesis for malignant pleural effusion.MethodsWe examined the medical records of all consecutive patients with malignant pleural effusion who underwent VATS talc pleurodesis from 2006 to 2008 at the Samsung Medical Center. Univariate and multivariate analyses were used to identify predictors of OS after VATS talc pleurodesis.ResultsDuring the study period, 91 patients underwent VATS talc pleurodesis to treat malignant pleural effusion. Early (within 30 days) and late (within 90 days) postoperative mortality rates were 9.9% (9 patients), and 25.3% (23), respectively. Median survival time after VATS talc pleurodesis was 10.5 months. The postoperative respiratory complication rate was 11% (10 patients), and included pneumonia (9) and acute respiratory distress syndrome (4). Multivariate analysis revealed that preoperative chemotherapy (P = 0.012), preoperative radiotherapy (P = 0.003), and Eastern Cooperative Oncology Group (ECOG) performance score 3 or 4 (P = 0.013) were independent risk factors of OS after VATS talc pleurodesis.ConclusionsWe identified previous chemotherapy or radiotherapy and poor performance status (ECOG 3 or 4) as significant predictors of OS after VATS talc pleurodesis. These prognostic factors can help surgeons select candidates for VATS pleurodesis for malignant pleural effusion.

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Predictors of mortality within three months in the patients with malignant pleural effusion

Cited by 48 publications

References 17 publications

Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion

Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion

Prognostic value of aberrant hypermethylation in pleural effusion of lung adenocarcinoma

Predictors of survival in patients who underwent video‐assisted thoracic surgery talc pleurodesis for malignant pleural effusion

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