Predictors of mortality in Middle East respiratory syndrome (MERS)

Hong, Kiho; Choi, Jeongyong; Hong, Seon-Hui; Lee, Jeewon; Kwon, Ji‐Soo; Kim, Sunmi; Park, Se Yoon; Rhee, Ji-Young; Kim, Baek-Nam; Choi, Hee Jung; Shin, Eui‐Cheol; Pai, Hyunjoo; Park, Su–Hyung; Kim, Sung-Han

doi:10.1136/thoraxjnl-2016-209313

Cited by 181 publications

(168 citation statements)

References 7 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…Previously, older age has been reported as an important independent predictor of mortality in SARS and MERS. 14,15 The current study confirmed that increased age was associated with death in patients with COVID-19. Previous studies in macaques inoculated with SARS-CoV found that older macaques had stronger host innate responses to virus infection than younger adults, with an Table 3: Risk factors associated with in-hospital death increase in differential expression of genes associated with inflammation, whereas expression of type I interferon beta was reduced.…”

Section: Discussionsupporting

confidence: 80%

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

et al. 2020

View full text Add to dashboard Cite

Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. MethodsIn this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratoryconfirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients).Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03-1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61-12·23; p<0·0001), and d-dimer greater than 1 µg/mL (18·42, 2·64-128·55; p=0·0033) on admission. Median duration of viral shedding was 20·0 days (IQR 17·0-24·0) in survivors, but SARS-CoV-2 was detectable until death in non-survivors. The longest observed duration of viral shedding in survivors was 37 days.Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 µg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.

show abstract

Section: Discussionsupporting

confidence: 80%

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Other studies on acute bunyavirus infection, Hantavirus, and Crimean-Congo hemorrhagic fever virus have reported that the binding of VEGF to its receptor contributes to vascular hyper-permeability, resulting in effusions [18,19]. Interestingly, we also detected an increased RANTES level in the late stages of SFTS, reminiscent of a previous study in which we reported its marked elevation also in the late stage of survivors with Middle East respiratory syndrome (MERS) [20]. Previous studies have similarly reported increased concentrations of RANTES in survivors of Ebola viral disease [21].…”

Section: Discussionsupporting

confidence: 84%

Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome

Kwon

Kim²,

Kim

et al. 2018

Journal of Clinical Virology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some studies showed that older age is associated with declined immune system ability [20]. Previously, older age has been reported as an associated factor for mortality in SARS [21] and MERS [22].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study

Nikpouraghdam

Farahani

Alishiri

et al. 2020

Journal of Clinical Virology

360

286

View full text Add to dashboard Cite

show abstract

Predictors of mortality in Middle East respiratory syndrome (MERS)

Cited by 181 publications

References 7 publications

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome

Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study

Contact Info

Product

Resources

About