Predictors of mortality in adult patients with dengue: a study from South India

Acharya, Vasudeva; Khan, Mohammed Fahad; Kosuru, Srinivas; Mallya, Sneha Deepak

doi:10.18203/2320-6012.ijrms20181495

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Also, there were no significant differences of thrombocyte count between male and female in early, critical or convalescence phases (p > 0,05). These finding was similar to result reported by Acharya, Khan, Kosuru, & Mallya (2018) where there was no relation of mortality with gender of the dengue patient (p = 0.534).…”

Section: Case Reportsupporting

confidence: 91%

Thrombocyte Count in Male and Female Adult of Dengue Hemorrhagic Fever Patients

2020

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The trend of dengue virus infection in Indonesia has changed from children to older groups. Some studies suggested that different gender might affect the different progression of dengue infection, but its mechanism was unclear. This study analyzed the difference by evaluating the daily thrombocyte count pattern. An analytic observational study with a retrospective design was conducted using the secondary data collected from medical records in Dr. Soetomo General Hospital Surabaya during 2017-2018. The samples were adult patients in the age range of 18-55 years old with DHF but without comorbidity or coinfection. The total number of samples was 40 patients. The average of thrombocyte count in both male and female patients decreased since the 3rd day of illness and reached the lowest level on the 6th day of illness then increased on the 7th day but did not reach the normal range. Although the majority of thrombocyte count in females was lower than males, there was no significant difference in thrombocyte count pattern between them. Keyword: Adult, DHF, Thrombocyte, GenderCorrespondence : heny-a@fk.unair.ac.id

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Section: Case Reportsupporting

confidence: 91%

Thrombocyte Count in Male and Female Adult of Dengue Hemorrhagic Fever Patients

2020

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“…6,28 While there are other studies on death in dengue, they examined the association with death in unselected dengue cases and were not prediction modelling studies. [39][40][41][42][43][44][45][46] Our study is the first modelling study, based on the latest and widely adopted WHO 2009 classification scheme, to model prediction of death in severe dengue cases. As mentioned above, there have been many studies that built models for identification of dengue and stratification of severity in dengue.…”

Section: Resultsmentioning

confidence: 99%

Multivariable prediction model for predicting deaths in severe dengue cases

Zaid

Leong

et al. 2019

Preprint

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Background. Many predictive models have been developed to predict an outbreak, identify and stratify dengue but none has predicted death in severe dengue cases. To build a predictive model for deaths in severe dengue, a multicentre retrospective cohort study was conducted. Methods. Patients with severe dengue based on the World Health Organisation (WHO) 2009 classification were studied. Demographic, clinical and laboratory data were collected at diagnosis of severe dengue. Penalised regression was used for variable selection and model-building. Ten-fold cross-validation with 1000 repeats were performed for internal validation. Results. A cohort of 786 severe dengue cases, including 35 deaths, was analysed. Our model that predicts death in severe dengue cases comprises eight independent predictors: persistent diarrhoea, body mass index, respiratory rate, platelet count, aspartate transaminase, serum bicarbonate, serum lactate and serum albumin. The area under the receiver operating characteristic curve is 89·6% with a sensitivity of 99·6%, specificity of 23·6%, positive predictive value of 96·6%, negative predictive value of 71·1%, positive likelihood ratio 1·45 and negative likelihood ratio 0·01. We also found that the proportion of patients that were in the febrile phase at diagnosis of severe dengue for the overall cohort, decompensated and compensated shock were 74·3%, 73% and 75·4%, respectively. Conclusions. We developed a high-performance dengue death prediction model comprising clinical and laboratory data, and deployed an open-access web-based tool (www.saifulsafuan.com/REPROSED2017E2) for any centre to utilise for local validation. We additionally found that a large majority of patients developed severe dengue during the febrile phase. Keywords: Dengue; severe; model; predict; deaths; phase.

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“…These findings were similar to a study in which overall mortality was 3.85%, variables associated with increased risk of death among the dengue patients were Age >40 years, presence of hypotension, presence of renal failure, encephalopathy, MODS, ARDS and bleeding tendency. 15…”

Section: Discussionmentioning

confidence: 99%

Study of gastrointestinal manifestations in Dengue fever

Prashanth

Manasa

2019

Int J Adv Med

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Background: Dengue is an arthropod borne viral haemorrhagic fever. In India between 2015-2017, 790 deaths have been recorded according to NVBDCP data. Gastrointestinal manifestations are among the most common manifestations in dengue fever, and are most often missed due to lack of awareness. This study aims to find the spectrum of Gastrointestinal manifestations and correlation of GI manifestations with severity of Dengue.Methods: A cross-sectional observational study was conducted on 100 consecutive cases of serologically confirmed Dengue fever. Patients were examined clinically, and laboratory data was assessed till they got discharged. Gastrointestinal manifestations of dengue fever were noted and analyzed.Results: This study included 100 consecutive cases of dengue fever. Mean age of the study population was 32.48+12.40 years of them 77 were males and 23 were female patients. Gastrointestinal manifestations were noted in 96% of the patients. GI manifestations noted were Nausea in 71%, Elevation of transaminases in 59%, vomiting in 54%, pain abdomen in 31%, Ascites in 24% hepatomegaly in 14%, diarrhoea in 13%, Acalculous cholecystitis in 13%, Acute fulminant hepatitis in 6%, Upper GI bleed in 6%, splenomegaly in 5%, and Acute pancreatitis in 4% of patients. Of these, GI manifestations like nausea, vomiting, pain abdomen, GI bleed, ascites, jaundice, elevation of transaminases, acute fulminant hepatitis and acute pancreatitis correlated with severity of Dengue fever . Conclusion: Gastrointestinal manifestations in Dengue fever are much more common than once thought of. In our study it was found in 96 percent of patients making it most common manifestations in dengue fever. Transaminitis and Atypical GI manifestations like acute pancreatitis, acute fulminant hepatitis may indicate severe Dengue. The differential diagnosis of an acute febrile syndrome with abdominal pain or gastrointestinal symptoms in patients living in endemic areas should include Dengue fever.

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Predictors of mortality in adult patients with dengue: a study from South India

Cited by 5 publications

References 18 publications

Thrombocyte Count in Male and Female Adult of Dengue Hemorrhagic Fever Patients

Thrombocyte Count in Male and Female Adult of Dengue Hemorrhagic Fever Patients

Multivariable prediction model for predicting deaths in severe dengue cases

Study of gastrointestinal manifestations in Dengue fever

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