Predictors of Mortality in 433 Nonagenarians Inside the Mugello Study: A 10 Years Follow-Up Study

Abstract

Objective to identify the predictors of mortality in a cohort of nonagenarians inside the “Mugello study” after 10 years follow-up. Methods Information on sociodemographic data, cognitive and functional status, lifestyle, medical history, and drug use was collected from 433 non-selected participants aged 90-99 years, living in the Mugello area (Italy). Participants were followed over 10 years and their dates of death were retrieved from the municipal registers. Cox regression analysis was used to determine significant potential prognostic factors. Results The mortality rate was 96.5%. Cox proportional hazards analysis showed that a lower cognitive status was significantly associated with higher mortality as well as a poorer functional status, a higher comorbidity, and a higher number of drugs consumption. Discussion Impaired cognitive function, loss of functional independence, higher comorbidity, and higher drugs intake were the stronger predictors of mortality.

Mortality in the Oldest-Old Adults After Discharge From Acute Geriatric Ward

“…In community nonagenarians, relationships between functional independence and cognitive function, and extended lifespan have been recently found. In Pancani et al's (2022) study, impaired cognitive function and loss of functional independence were the stronger predictors of mortality. Some studies have suggested that dementia adversely influences clinical outcomes in patients hospitalized for acute diseases (Guijarro et al, 2010;Sampson, et al, 2009).…”