Predictors of Mortality and Hospitalization for Cardiac Causes in Patients with Heart Failure and Nonischemic Heart Disease: A Subanalysis of the ALPHA Study

Anselmino, Matteo; Ferrari, Gaetano Maria De; Massa, Riccardo; Manca, Lorenzo; Tritto, Massimo; Molon, Giulio; Curnis, Antonio; Devecchi, Paolo; Braga, Simona Sarzi; Bartesaghi, G.; Klersy, Catherine; Accardi, Francesco; Salerno‐Uriarte, Jorge A.

doi:10.1111/j.1540-8159.2008.02286.x

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…Prognostic factors of HF include LVEF, NYHA class, older age, male sex, low exercise capacity (6MWT), low systolic blood pressure, low hemoglobin, etc. [ 19 , 20 , 21 ]. Several clinical prediction models have been created for HF (The Seattle Heart Failure Model, etc.)…”

Section: Discussionmentioning

confidence: 99%

Relationships of Whole-Heart Myocardial Mechanics and Cardiac Morphometrics by Transthoracic Echocardiography with Main Prognostic Factors of Heart Failure in Non-Ischemic Dilated Cardiomyopathy

Mėlinytė-Ankudavičė

Ereminienė

Mizarienė

et al. 2023

JCM

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Background: there are many prognostic factors of heart failure (HF) based on their evaluation from imaging, to laboratory tests. In clinical practice, it is crucial to use widely available, cheap, and easy-to-use prognostic factors, such as left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) functional class, 6 min walk test (6MWT), B-type natriuretic peptide (BNP), etc. We sought to evaluate the relationships between whole-heart myocardial mechanics and cardiac morphometrics with the main commonly used prognostic factors of HF in patients with non-ischemic dilated cardiomyopathy (NIDCM). Methods and results: two-dimensional (2D) echocardiography for myocardial mechanics (global longitudinal, radial, and circumferential strains of the left ventricle; right ventricular longitudinal strain; strain values of reservoir, conduit, and contraction function of both atria) and cardiac morphometric (diameters and volumes of both atria and ventricles) parameters were performed, and the HF main traditional prognostic factors were identified. We assessed 109 patients (68.8% male; 49.7 ± 10.5 years) with newly diagnosed NIDCM. Myocardial mechanics and morphometrics were weakly correlated with the patient’s age, gender, and smoking (R = 0.2, p < 0.05). Stronger relationships were observed with NYHA class, 6MWT, and BNP (the strongest correlations were with LVEF: R = −0.499, R 0.462, R = −0.461, p < 0.001, respectively). There were moderately strong correlations with LVEF and other whole-heart myocardial mechanics or morphometrics. Moreover, LVEF with global regurgitation volume (GRV) and right ventricle free wall longitudinal strain (RVFWLS) were the most usually detected parameters in multivariate analysis to be associated with changes in HF prognostic factors. Conclusions: in NIDCM patients, the main prognostic factors of HF are correlated with whole-heart myocardial mechanics and morphometrics. However, LVEF, GRV, and RVFWLS are the most usually found 2D echocardiographic factors associated with changes in HF prognostic factors.

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Section: Discussionmentioning

confidence: 99%

Relationships of Whole-Heart Myocardial Mechanics and Cardiac Morphometrics by Transthoracic Echocardiography with Main Prognostic Factors of Heart Failure in Non-Ischemic Dilated Cardiomyopathy

Mėlinytė-Ankudavičė

Ereminienė

Mizarienė

et al. 2023

JCM

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“…Furthermore, large LVIDd has been reported as an independent predictor for all-cause mortality or hospitalization for cardiac causes [32]. We have in an earlier study found that ambulatory ST segment depression, as a measure of ischemic heart disease (IHD), was associated with lower cognitive function, both visuospatial and verbal [14].…”

Section: Discussionmentioning

confidence: 99%

Cardiac ventricular dimensions predict cognitive decline and cerebral blood flow abnormalities in aging men

et al. 2013

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BackgroundThe aims of this study are to examine possible associations between left cardiac ventricular measures in sixth decade and cognitive performance, both cross sectionally and longitudinally, and to examine if left cardiac ventricular measures could predict future changes in cerebral blood flow (CBF).Methods211 elderly men from a cohort of the population study “Men born in 1914” completed M-mode echocardiography and a cognitive test battery at age 68. The cognitive test battery was repeated at age 81. CBF was estimated with 99mTc-HMPAO SPECT in 72 survivors at age 83. Cognitive performance at baseline and at 1st follow up and CBF at 1st follow up were analysed in relation to left ventricular internal dimension in diastole (LVIDd mm/m2) and fractional shortening (FS).ResultsSubjects with enlarged LVIDd at age 68 had poorer results on verbal and speed-performance tests at baseline and on verbal and visuo-spatial tests 14 years later on. Low FS was associated with decreased results on visuo-spatial tests at baseline. There was an inverse relationship between LVIDd and both verbal and spatial ability at the baseline and after 14 years of follow-up. Normotensive men with lower FS had also decreased CBF in a majority of brain areas 14 years later.ConclusionsMild echocardiographic abnormalities in 68 ys.-old men, as increased LVIDd and lower FS, are associated with lower cognitive test results and may predict cognitive decline and silent cerebral perfusion abnormalities 14 years later.

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“…253 Outras variáveis clínicas associadas a maior risco de eventos arrítmicos nesta população são o não uso de betabloqueadores e a pressão arterial sistólica. 254,255 Exames laboratoriais, como hemoglobina, ácido úrico e peptídio natriurético atrial (BNP), aparecem como preditores de mortalidade e eventos arrítmicos em alguns estudos. 256 A redução da FEVE é considerada o principal fator de risco para MSC e mortalidade total em pacientes com IC.…”

Section: Miocardiopatia Não Isquêmicaunclassified

Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023

Teixeira¹,

Fagundes²,

Baggio³

et al. 2023

Arquivos Brasileiros De Cardiologia

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Predictors of Mortality and Hospitalization for Cardiac Causes in Patients with Heart Failure and Nonischemic Heart Disease: A Subanalysis of the ALPHA Study

Cited by 10 publications

References 14 publications

Relationships of Whole-Heart Myocardial Mechanics and Cardiac Morphometrics by Transthoracic Echocardiography with Main Prognostic Factors of Heart Failure in Non-Ischemic Dilated Cardiomyopathy

Relationships of Whole-Heart Myocardial Mechanics and Cardiac Morphometrics by Transthoracic Echocardiography with Main Prognostic Factors of Heart Failure in Non-Ischemic Dilated Cardiomyopathy

Cardiac ventricular dimensions predict cognitive decline and cerebral blood flow abnormalities in aging men

Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023

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