Predictors of Mortality Among Hospitalized Patients With Esophageal Cancer

Enofe, Ikponmwosa; Bedi, Prabhjot Singh; Manoj, P; Nemakayala, Divyesh; Kandola, Samanjit Kaur; Xiao, Ling; Singh, Vikas; Laird-Fick, Heather; Abougergi, Marwan S.

doi:10.14309/00000434-201810001-00375

Cited by 1 publication

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“…Previous studies reported that age and high Charlson comorbidity score are significant predictors of mortality in esophageal cancer 31 . Similarly, the present study showed that patients with comorbidity had a higher mortality risk in advanced‐stage disease.…”

Section: Discussionsupporting

confidence: 85%

“…Previous studies reported that age and high Charlson comorbidity score are significant predictors of mortality in esophageal cancer. 31 Similarly, the present study showed that patients with comorbidity had a higher mortality risk in advanced-stage disease. The high mortality rate could also be attributed to complications arising from multiple comorbidities that the patients had, which complicate the management of esophageal cancer.…”

Section: Discussionsupporting

confidence: 75%

“…Furthermore, another study also reported a higher 90‐day postoperative mortality rate after esophagectomy in low and middle‐income countries 28 . The mortality rate of esophageal cancer patients was 43.1% in our setting, which is higher than findings from Japan (18.7%), the United States (8.9%), and South Korea (7.9%) 29–31 . This observation may be due to advanced healthcare services in these countries.…”

Section: Discussioncontrasting

confidence: 68%

“…28 The mortality rate of esophageal cancer patients was 43.1% in our setting, which is higher than findings from Japan (18.7%), the United States (8.9%), and South Korea (7.9%). [29][30][31] This observation may be due to advanced healthcare services in these countries. In addition, due to the overwhelming infectious disease burden and resource constraints, cancer care is the least priority of healthcare services in sub-Saharan Africa, leading to high mortality rates due to cancer.…”

Section: Discussionmentioning

confidence: 98%

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Determinants of survival outcomes among esophageal cancer patients at a national referral hospital in Kenya

Degu

Karimi

Opanga

et al. 2022

Chronic Diseases and Translational Medicine

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Introduction:The overall 5-year survival rate for esophageal cancer patients in low-and middle-income countries was reported to be low, despite the availability of advanced treatments. Thus, this study aimed to assess determinants of survival outcomes among esophageal cancer patients in Kenya. Methods: A retrospective cohort study was employed among 299 adult esophageal cancer patients. The data were collected using a data abstraction tool consisting of patients' clinical characteristics and survival outcome measuring parameters. Statistical Package for the Social Sciences (SPSS) statistical software (version 20.0, IBM. USA) was used to analyze the data. The Kaplan-Meier and Cox regression analyses were used to determine the survival outcome and determinants of mortality, respectively. Results: The mortality rate was 43.1%, and 11.1% of patients demonstrated distant metastases in the follow-up period. Despite treatment, 20.1% had progressed disease, and 13.0% did not respond to treatment. Radiotherapy (AHR: 3.3, 95% CI: 1.4−7.8, p = 0.007), chemotherapy (AHR: 3.9, 95% CI: 1.2−6.1, p = 0.020), and chemoradiation (AHR: 5.6, 95%CI: 1.6−10.2, p = 0.006) were the significant determinants of survival in advanced stage (III and and IV) patients. Conclusions: There was a high mortality rate, disease progression, and nonresponse of esophageal cancer patients. Hence, it is essential to improve the survival of patients through early detection and timely initiation of the available treatment options.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 75%

Section: Discussioncontrasting

confidence: 68%