Predictors of micronutrient status in men and women over 75 years old living in the community

McNeill, Geraldine; Vyvyan, Juliet; Peace, Heather; McKie, Linda; Seymour, Gwyn; Hendry, Judith; MacPherson, Isobel

doi:10.1079/bjn2002706

Cited by 19 publications

(11 citation statements)

References 15 publications

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“…Considering that the health status of an individual is the result of complex interactions between personal characteristics, genetic make-up, living place, nutrition and lifestyle, physiological parameters and the presence of subclinical or of overt chronic disease(s) and of treatments, then the Skaaby et al study lends support to the possibility that the 25(OH)D could represent a synthetic indicator of the health status of an individual that provides a quantitative information on a vast number of factors that may have positive and negative influences on the health status. This possibility is supported by the observation that of all vitamins and anti-oxidative compounds found in the serum, the 25(OH)D concentration is probably the most sensitive to changes in health status [6].…”

supporting

confidence: 60%

Vitamin D status as a synthetic biomarker of health status

Autier

2015

Endocrine

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supporting

confidence: 60%

Vitamin D status as a synthetic biomarker of health status

Autier

2015

Endocrine

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“…A full description of the recruitment of subjects and methods of measurement of blood analytes has been reported elsewhere 7 . Briefly, a random sample of individuals aged 75 years old or over living in the community in Aberdeen, Scotland were selected from the Community Health Index (CHI), a comprehensive list of all patients registered with family doctors in the UK National Health Service.…”

Section: Participants and Measurement Of Nutritional Statusmentioning

confidence: 99%

Nutritional status and subsequent all-cause mortality in men and women aged 75 years or over living in the community

2007

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We prospectively investigated relationships between blood markers of Fe, vitamin B 12 , folate, vitamin C and vitamin D status and subsequent allcause mortality in 208 men and 191 women aged 75 years or over living in the community in Aberdeen, Scotland. The participants had been recruited for a cross-sectional study in 1999 -2000 when they completed health and lifestyle questionnaires and had blood samples taken for analysis of serum ferritin, serum vitamin B 12 , erythrocyte folate, plasma vitamin C and serum 25-hydroxycholecalciferol. Mortality was ascertained on national databases up to December 2005, with a median time of follow up of 69·2 (range 1·0 -79·9) months. Participants were divided into sexspecific quintiles of baseline levels for each nutrient, and hazard ratios were estimated with Cox proportional hazard models adjusted for age and sex with the significance of linear trends in the associations assessed by logistic regression. There was no significant association between blood markers of Fe, vitamin B 12 or folate status at baseline and mortality, but vitamin D status at baseline was inversely related to mortality (P for trend , 0·001). For vitamin C there was no evidence of a linear trend but participants in the lowest quintile of plasma levels had a significantly higher risk of death than those in the highest quintile. Randomized controlled trials of lifestyle changes which improve vitamin status are needed to assess whether these associations could be causal. . The high prevalence of nutritional deficiency in old individuals is partly due to reduced appetite and lower physical activity as a result of musculo-skeletal and other health problems. The decrease in energy and nutrient intake may be compounded by malabsorption due to poor function of the digestive system or side effects of medication.There is limited evidence for a relationship between low nutritional status and subsequent mortality in old individuals. A 29-year cohort study based on the 1969 Busselton Health Survey in Western Australia found no association between folate or vitamin B 12 status and all-cause mortality 2 . By contrast, a 4-year cohort study of individuals over 75 years old living in the community in the UK found that those in the lowest quintile of vitamin C status had a significantly lower hazard ratio for all-cause mortality than those in the highest quintile 3 . A beneficial effect of vitamin C was also suggested by large cohort studies which included younger adults 4,5 . A 31-month follow up of men and women living in residential age care facilities in Sydney, Australia found that vitamin D status was significantly associated with allcause mortality after adjustment for age and sex, though this effect was not seen after further adjustment for confounding variables such as health status at baseline 6 . In an earlier study designed to identify predictors of poor nutritional status in later life, we obtained measurements of blood markers of Fe, vitamin B 12 , folate, vitamin C and vitamin D status in 398 men and women...

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“…Vitamin D deficiency has long been recognised as a major problem in elderly men and women with levels as low as 21 nmol/l observed [48,49,90]. While the problem is particularly acute for those living in institutions, [90][91][92][93][94][95][96][97][98] low vitamin D status is also evident in community dwelling older people. It is not clear if low vitamin D status is a cause or an effect of institutionalisation.…”

Section: Adultsmentioning

confidence: 97%

Vitamin D: Status, Supplementation and Immunomodulation

Barnes¹,

Robson²,

Bonham³

et al. 2006

CNF

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Numerous studies have shown suboptimal vitamin D status in populations at high geographical latitudes, owing to a reduced capacity to synthesise vitamin D, especially during wintertime. Vitamin D supplementation has been shown to be effective at maintaining adequate vitamin D status throughout the year in these countries. Classically reported to play a central role in bone health, vitamin D has more recently been shown to modulate immune function by promoting an anti-inflammatory response, which may be related to onset or progression of autoimmune inflammatory disorders. One such condition is multiple sclerosis (MS). There is an increasing incidence of MS with increasing latitude, with higher prevalence reported in countries further away from the equator, where vitamin D synthesis is inadequate. Vitamin D has been shown to have positive effects on the animal model of MS, experimental autoimmune encephalomyelitis. However, there have been few human intervention studies to investigate the effect of vitamin D supplementation on symptoms of MS or indeed of other autoimmune disorders. Further research is required to examine the potential beneficial role of vitamin D in MS to ultimately determine the optimal vitamin D status required to alleviate symptoms and possibly prevent this and other chronic diseases.

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Predictors of micronutrient status in men and women over 75 years old living in the community

Cited by 19 publications

References 15 publications

Vitamin D status as a synthetic biomarker of health status

Vitamin D status as a synthetic biomarker of health status

Nutritional status and subsequent all-cause mortality in men and women aged 75 years or over living in the community

Vitamin D: Status, Supplementation and Immunomodulation

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