Predictors of maternal drinking trajectories before and after pregnancy: evidence from a longitudinal study

Tran, Nam; Najman, Jake M.; Hayatbakhsh, Reza

doi:10.1111/ajo.12294

Cited by 40 publications

(57 citation statements)

References 35 publications

(55 reference statements)

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“…Mothers who were unmarried and multiparous were more likely to be in the high-use category. 23 To our knowledge, our study is the first in which researchers report on LCA for PAE and associated growth and neurodevelopmental outcomes in offspring. The relatively homogenous sample of women, recruited 1:1 for alcohol exposure, allowed for a broad and heterogeneous distribution of alcohol consumption in a relatively small sample.…”

Section: Figurementioning

confidence: 82%

“…In a second study of 6597 women recruited in Australia between 1981 and 1983, the investigators performed LCA on drinking measured at 4 time points: prepregnancy, early pregnancy, late pregnancy, and 6 months postpartum. 23 Exposure was defined at each time point as the product of the frequency and quantity of alcohol consumption. Three trajectories were identified: high consumption (with reduction in early pregnancy), light consumption (<0.5 glass per day), and abstainers.…”

Section: Figurementioning

confidence: 99%

“…Researchers in recent studies have used longitudinal cluster analysis (LCA) methods to summarize complex individual-level alcoholexposure trajectories in women, 22 including 2 studies of alcohol use patterns in pregnancy. 20,23 Such methods are used to classify individuals with similar patterns of alcohol dosing and frequency over a specified time period into distinct groups. However, researchers in none of the previously published studies further examined the trajectory groups to predict infant outcomes.…”

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confidence: 99%

“…However, researchers in none of the previously published studies further examined the trajectory groups to predict infant outcomes. 20,23 Our purpose in this study was to describe trajectories of PAE in a prospective cohort study of pregnant women and determine if those exposure trajectories were associated with adverse infant outcomes.…”

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confidence: 99%

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Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development

et al. 2019

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a, b the CIFASD BACKGROUND: Previous studies have had inconsistent findings regarding the quantity and frequency of prenatal alcohol exposure (PAE) that lead to deficits in growth and neurodevelopment. This may be due to imprecise methods of exposure classification. Our objective in this study was to employ longitudinal trajectory modeling of maternal drinking patterns associated with infant growth or neurodevelopmental deficits to a homogenous sample of mothers and infants. METHODS: From a sample of 471 pregnant women prospectively enrolled in a longitudinal study in the Ukraine, we performed a longitudinal cluster analysis of drinking patterns across gestation. We employed multivariable regression analyses to determine if each trajectory group was associated with infant weight, length, or head circumference at birth or psychomotor or mental deficits in infancy. RESULTS: We identified 5 distinct PAE trajectory groups: minimal or no PAE throughout gestation, low-to-moderate PAE with discontinuation early in gestation, low-to-moderate PAE sustained across gestation, moderate-to-high PAE with reduction early in gestation, and high PAE sustained across gestation. The highest-trajectory group was associated with deficits in infant weight and length at birth and deficits in psychomotor and mental performance at 6 to 12 months of age. Although confidence intervals overlapped, low-tomoderate sustained use was more strongly associated with most negative infant outcomes than moderate-to-high PAE with early reduction. CONCLUSIONS: With these findings, we confirm that high, sustained PAE confers the highest risk for adverse infant outcomes but demonstrate that even low-to-moderate PAE continued across gestation is associated with certain deficits. This approach may be used to help clinicians identify high-risk infants for targeted early intervention.

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Section: Figurementioning

confidence: 82%

Section: Figurementioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development

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“…Like most Western countries, official healthcare guidelines in Switzerland apply the precautionary principle of recommending that women abstain from any alcohol consumption while pregnant [5]. Although a majority of women abstain from alcohol once they become pregnant, a number of them continue drinking alcohol, albeit it at a substantially reduced rate [6]. The estimated prevalence of alcohol consumption during pregnancy is higher in Switzerland than in several other European countries [7].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy as a transition: First‐time expectant couples′ experience with alcohol consumption

Gouilhers

Meyer

Inglin³

et al. 2019

Drug and Alcohol Review

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Introduction and AimsMost official healthcare guidelines apply the precautionary principle by recommending that pregnant women abstain from any alcohol consumption. However, a number of women continue drinking alcohol while pregnant. The aim of this study was to investigate couples′ experiences of the issue of alcohol consumption during pregnancy as a transitional process.Design and MethodsThirty semi‐directive joint interviews were conducted with couples expecting their first child in Switzerland. Interviews were analysed thematically with the help of ATLAS.ti.ResultsCouples endorsed the imperative of changing drinking habits and all the women reduced their alcohol consumption, although some reported difficulties. First, we identified three themes describing how couples experienced the woman′s change of drinking habits as a smooth transition: Internalisation of risk discourses, abstinence as a social norm and embodiment of alcohol aversion. Second, we emphasised four kinds of difficulties that couples encountered in their everyday lives: burden of risk discourses, conflicting advice, social occasions and desire for alcohol.Discussion and ConclusionsThis paper makes a significant contribution by examining prenatal drinking change as a transition. In this conceptualisation, the change of alcohol consumption is a relational process that is shaped by multiple changes and social norms. Our findings have important implications for practice. First, health professionals should be aware of the difficulties women experience when they abstain from alcohol during pregnancy. Second, our findings suggest the importance of a patient‐centred approach that considers the role of the partner in supporting a pregnant woman′s change of alcohol consumption.

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Early‐lifeexposure to alcohol and the risk ofalcohol‐inducedliver disease in adulthood

Asiedu

Nyakudya

Lembede

et al. 2021

Birth Defects Research

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Alcohol consumption remains prevalent among pregnant and nursing mothers despite the well‐documented adverse effects this may have on the offspring. Moderate‐to‐high levels of alcohol consumption in pregnancy result in fetal alcohol syndrome (FAS) disorders, with brain defects being chief among the abnormalities. Recent findings indicate that while light‐to‐moderate levels may not cause FAS, it may contribute to epigenetic changes that make the offspring prone to adverse health outcomes including metabolic disorders and an increased propensity in the adolescent‐onset of drinking alcohol. On the one hand, prenatal alcohol exposure (PAE) causes epigenetic changes that affect lipid and glucose transcript regulating genes resulting in metabolic abnormalities. On the other hand, it can program offspring for increased alcohol intake, enhance its palatability, and increase acceptance of alcohol's flavor through associative learning, making alcohol a plausible second hit for the development of alcohol‐induced liver disease. Adolescent drinking results in alcohol dependence and abuse in adulthood. Adolescent drinking results in alcohol dependence and abuse in adulthood. Alterations on the opioid system, particularly, the mu‐opioid system, has been implicated in the mechanism that induces increased alcohol consumption and acceptance. This review proposes a mechanism that links PAE to the development of alcoholism and eventually to alcoholic liver disease (ALD), which results from prolonged alcohol consumption. While PAE may not lead to ALD development in childhood, there are chances that it may lead to ALD in adulthood.

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Predictors of maternal drinking trajectories before and after pregnancy: evidence from a longitudinal study

Cited by 40 publications

References 35 publications

Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development

Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development

Pregnancy as a transition: First‐time expectant couples′ experience with alcohol consumption

Early‐lifeexposure to alcohol and the risk ofalcohol‐inducedliver disease in adulthood

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