Predictors of mammographic microcalcifications

Azam, Shadi; Eriksson, Mikael; Sjölander, Arvid; Gabrielson, Marike; Hellgren, Roxanna; Czene, Kamila; Hall, Per

doi:10.1002/ijc.33302

Cited by 10 publications

(10 citation statements)

References 40 publications

(100 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, we failed to observe the inverse association of vitamin D and calcium intake with breast density in premenopausal women as reported in several observational studies 19,20 . Nonetheless, we observed that higher vitamin D and calcium intakes were associated with lower breast density in women without microcalcifications, a group that tend to be younger than women with microcalcifications 31 . However, these inconstancies may partly be explained by the study population.…”

Section: Discussioncontrasting

confidence: 64%

“…As it remains unclear if the presence of microcalcifications is a risk factor or a marker of breast cancer progression, and knowing that the presence of microcalcification clusters was recently associated with high breast density, 31 we assessed the association of daily vitamin D and calcium intakes with age-related lobular involution and breast density adjusting for and stratifying for microcalcification status.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Association between vitamin D and calcium intakes, breast microcalcifications, breast tissue age-related lobular involution and breast density

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 64%

Section: Methodsmentioning

confidence: 99%

Association between vitamin D and calcium intakes, breast microcalcifications, breast tissue age-related lobular involution and breast density

et al. 2022

View full text Add to dashboard Cite

show abstract

“…These results are novel but not surprising, given that these risk models directly or indirectly take mammographic features into account. Specifically, the KARMA model 27 directly incorporates breast density, masses, microcalcifications, and their asymmetries; the Tyrer-Cuzick model 21 incorporates hormone-related factors, which can affect mammographic features 28,29 ; and the polygenic risk model positively correlates with not only mammographic density but also microcalcifications and masses. 30 However, when restricting our analyses to women who were recalled, we found that model estimated risks were associated with higher risk of having true-positive than false-positive recalls.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated With False-Positive Recalls in Mammography Screening

Mao

Humphreys

et al. 2023

Journal of the National Comprehensive Cancer Network

Self Cite

View full text Add to dashboard Cite

Background: We aimed to identify factors associated with false-positive recalls in mammography screening compared with women who were not recalled and those who received true-positive recalls. Methods: We included 29,129 women, aged 40 to 74 years, who participated in the Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA) between 2011 and 2013 with follow-up until the end of 2017. Nonmammographic factors were collected from questionnaires, mammographic factors were generated from mammograms, and genotypes were determined using the OncoArray or an Illumina custom array. By the use of conditional and regular logistic regression models, we investigated the association between breast cancer risk factors and risk models and false-positive recalls. Results: Women with a history of benign breast disease, high breast density, masses, microcalcifications, high Tyrer-Cuzick 10-year risk scores, KARMA 2-year risk scores, and polygenic risk scores were more likely to have mammography recalls, including both false-positive and true-positive recalls. Further analyses restricted to women who were recalled found that women with a history of benign breast disease and dense breasts had a similar risk of having false-positive and true-positive recalls, whereas women with masses, microcalcifications, high Tyrer-Cuzick 10-year risk scores, KARMA 2-year risk scores, and polygenic risk scores were more likely to have true-positive recalls than false-positive recalls. Conclusions: We found that risk factors associated with false-positive recalls were also likely, or even more likely, to be associated with true-positive recalls in mammography screening.

show abstract

“…The full model was adjusted for age, smoking status, BMI, lipid-lowering medication, hypertension, physical activity, alcohol consumption, education, age at first birth, menopausal status, HRT use, and oral contraception use. Since a BC diagnosis and subsequent treatment may be a significant competing risk for cardiometabolic mortality, we also performed competing risk analyses with the crr function from the cmprsk package 20 in R. Finally, the age-adjusted mortality rate and confidence intervals per 1000 person-years was computed with ageadjust.direct function implemented in the library epitools in R. 49…”

Section: Methodsmentioning

confidence: 99%

“…In contrast, higher body mass index (BMI), current smoking behaviour as well as moderate to high alcohol consumption resulted in fewer MC. 20 Importantly, multiple reports indicated that mammographic MC are associated with increased prevalence and incidence of cardiovascular and coronary artery disease (summarized in 21 ). Similarly, a higher number of MC are frequently observed in women with chronic renal failure, 22 , 23 thus strongly implicating MC to be involved in multiple cardiometabolic diseases.…”

Section: Introductionmentioning

confidence: 99%

Mammographic features are associated with cardiometabolic disease risk and mortality

Graßmann

Yang

Eriksson

et al. 2021

European Heart Journal

Self Cite

View full text Add to dashboard Cite

Aims In recent years, microcalcifications identified in routine mammograms were found to be associated with cardiometabolic disease in women. Here, we aimed to systematically evaluate the association of microcalcifications and other mammographic features with cardiometabolic disease risk and mortality in a large screening cohort and to understand a potential genetic contribution. Methods and results This study included 57 867 women from a prospective mammographic screening cohort in Sweden (KARMA) and 49 583 sisters. Cardiometabolic disease diagnoses and mortality and medication were extracted by linkage to Swedish population registries with virtually no missing data. In the cardiometabolic phenome-wide association study, we found that a higher number of microcalcifications were associated with increased risk for multiple cardiometabolic diseases, particularly in women with pre-existing cardiometabolic diseases. In contrast, dense breasts were associated with a lower incidence of cardiometabolic diseases. Importantly, we observed similar associations in sisters of KARMA women, indicating a potential genetic overlap between mammographic features and cardiometabolic traits. Finally, we observed that the presence of microcalcifications was associated with increased cardiometabolic mortality in women with pre-existing cardiometabolic diseases (hazard ratio and 95% confidence interval: 1.79 [1.24–2.58], P = 0.002) while we did not find such effects in women without cardiometabolic diseases. Conclusions We found that mammographic features are associated with cardiometabolic risk and mortality. Our results strengthen the notion that a combination of mammographic features and other breast cancer risk factors could be a novel and affordable tool to assess cardiometabolic health in women attending mammographic screening.

show abstract

Predictors of mammographic microcalcifications

Cited by 10 publications

References 40 publications

Association between vitamin D and calcium intakes, breast microcalcifications, breast tissue age-related lobular involution and breast density

Association between vitamin D and calcium intakes, breast microcalcifications, breast tissue age-related lobular involution and breast density

Factors Associated With False-Positive Recalls in Mammography Screening

Mammographic features are associated with cardiometabolic disease risk and mortality

Contact Info

Product

Resources

About