Predictors of long‐term distress in female partners of men diagnosed with prostate cancer

Hyde, Melissa K.; Legg, Melissa; Occhipinti, Stefano; Lepore, Stephen J.; Ugalde, Anna; Zajdlewicz, Leah; Laurie, Kirstyn; Dunn, Jeff; Chambers, Suzanne K.

doi:10.1002/pon.4617

Cited by 24 publications

(30 citation statements)

References 38 publications

(84 reference statements)

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“…In addition, female partners of men with prostate cancer frequently report fear of what the future may hold, fear of recurrence or progression, and treatment-related concerns [6,7]. Female partners tend to be more distressed than the patients themselves, and rates of major depression and generalized anxiety disorder may be up to twice as high as in the general population and remain elevated long after treatment [6][7][8][9]. However, most of the reported estimates stem from small studies with short follow-up.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners

Hartung¹,

Moustsen-Helms

Larsen

et al. 2020

J Cancer Surviv

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Purpose To estimate the risk of first-time antidepressant prescriptions as a proxy for depression or anxiety and associated risk factors in patients with prostate cancer and their female partners. Methods We followed all men (n = 25,126) and their female cohabiting partners (n = 8785) without a history of cancer or antidepressants from the Danish Diet, Cancer and Health cohort from 1997 to 2014 or 2010, respectively. We estimated the cumulative incidence of first-time antidepressant prescriptions in men with prostate cancer compared with cancer-free men and their respective female partners, using the Danish National Prescription Registry. Sociodemographic, lifestyle-related, and clinical risk factors were assessed using Cox regression models. Results A total of 1828 men were diagnosed with prostate cancer of whom 15% received antidepressants. The unadjusted hazard ratio of antidepressant prescription was 2.18 (95%CI, 1.92, 2.48) for men with prostate cancer and 1.27 (95%CI, 0.87, 1.85) for their partners, compared with cancer-free men and their partners, respectively. After adjusting for sociodemographic, lifestyle-related, and comorbidity factors, this risk was 2-fold to 4-fold increased among patients, but not significantly increased among partners. Significant risk factors among patients were curative and palliative treatment (vs. active surveillance and watchful waiting), nonlocalized disease, and short education. Conclusions Men with prostate cancer have a higher risk of receiving antidepressant medication than cancer-free men. Clinical characteristics can help clinicians in identifying patients at a high risk of depression or anxiety. Implications for Cancer Survivors Men with prostate cancer who experience symptoms of depression or anxiety should seek professional help early on. Patient education could aid in raising awareness and reducing the stigma associated with mental disorders.

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Section: Introductionmentioning

confidence: 99%

Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners

Hartung¹,

Moustsen-Helms

Larsen

et al. 2020

J Cancer Surviv

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“…It is evident that many men with PCa depend on their partner for emotional and practical support, and the predominant role of partners have been portrayed as "health agents and advocates" [3], "health monitors" and "sel ess supporters" [4]. However, female partners of men diagnosed with prostate cancer are also more likely to have higher levels of anxiety compared to aged matched female samples [5], and experience heightened risk for depression [6].…”

Section: Introductionmentioning

confidence: 99%

Female partner experiences of prostate cancer patients’ engagement with a community-based football intervention: a qualitative study

Midtgaard

Tjørnhøj‐Thomsen²,

Rørth

et al. 2020

Preprint

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Background Prostate cancer is often labelled a couple’s disease wherein the partner plays an important role in the man’s illness management and related health promotion activities. The aim of this study was to explore partner experiences of prostate cancer patients’ engagement with a community-based football program. Methods Eight audio-visual recorded semi-structured focus group interviews were conducted with a total of 39 female partners of men with prostate cancer who participated in a community-based football program as part of the nationwide FC Prostate Community Trial (NCT02430792). Data was managed with the software program Nvivo 11 and analysed inductively to derive thematic findings. Results The four thematic findings were: 1) ‘Hope of a new beginning’ which included stories of hope that football would mitigate the negative effects of men’s prostate cancer treatment[s]; 2) ‘My new partner’ was characterized by attributing connections between physical activity and elevated mood as a by-product of men’s involvement in the program; 3) ‘Football first’ included assertions of the couples mutual commitment to the football program; and 4) ‘Invisible needs’ contrasted insecurity, and unforeseen challenges for partners feeling somewhat neglected. Overall, the results confirm the need for cohesion and flexibility amongst couple-dyads to ensure partners and men with prostate cancer benefit from their involvement in football programs. Conclusions This study indicates that prostate cancer survivors’ engagement with community-based football are intricately connected to gender relations, roles and identities. In many instances, these gendered dimensions aided positive dyadic coping and long-term exercise adherence.

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“…Evidence also shows that some partners experience more distress than patients (Cliff & MacDonagh, ; Couper et al, ; Eton et al, ). Partner distress can be long‐term, with greater distress linked to disease‐related (e.g., increased caregiver burden, disease‐specific quality of life), individual (e.g., coping style, stress appraisal, physical health) and relationship (e.g., decreased relationship satisfaction, intimacy or functioning) factors (Chambers et al, ; Couper et al, ; Harden et al, ; Hyde et al, ; Wootten, Abbott, Farrell, Austin, & Klein, ).…”

Section: Introductionmentioning

confidence: 99%

“…Cancer‐specific distress is also an important outcome for caregivers of cancer patients. For example, in a study of 427 female partners of prostate cancer survivors (2–4 years post‐treatment) who were followed up over 24 months, higher caregiver burden and more threat appraisals were associated with increased distress, anxiety, depression, and cancer‐specific distress over time (as measured by the HADS and Impact of Events Scale‐Revised [IES‐R]; Hyde et al ).). However, there does not appear to be any published studies examining validity of the DT against cancer‐specific distress measures such as the IES‐R.…”

Section: Introductionmentioning

confidence: 99%

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The validity of the Distress Thermometer in female partners of men with prostate cancer

et al. 2018

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Female partners of prostate cancer (PCa) survivors experience heightened psychological distress that may be greater than that expressed by PCa patients. However, optimal approaches to detect distressed, or at risk of distress, partners are unclear. This study applied receiver operating characteristics analysis to evaluate diagnostic accuracy, sensitivity and specificity of the Distress Thermometer (DT) compared to widely used measures of general (Hospital Anxiety and Depression Scale) and cancer‐specific (Impact of Events Scale‐Revised) distress. Participants were partners of men with localised PCa (recruited around diagnosis) about to undergo or had received surgical treatment (N = 189), and partners of men diagnosed with PCa who were 2–4 years post‐treatment (N = 460). In both studies, diagnostic utility of the DT overall was not optimal. Although area under the curve scores were acceptable (ranges: 0.71–0.92 and 0.83–0.94 for general and cancer‐specific distress, respectively), sensitivity, specificity and optimal DT cut‐offs for partner distress varied for general (range: ≥2 to ≥5) and cancer‐specific (range: ≥3 to ≥5) distress both across time and between cohorts. Thus, it is difficult to draw firm conclusions about the diagnostic capabilities of the DT for partners or recommend its use in this population. More comprehensive screening measures may be needed to detect partners needing psychological intervention.

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Predictors of long‐term distress in female partners of men diagnosed with prostate cancer

Abstract: A substantial subgroup of partners experience ongoing anxiety, with depression less prevalent but also persistent. Caregiver burden, partner self-efficacy, threat, and challenge appraisals present as potential supportive care targets.

Cited by 24 publications

References 38 publications

Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners

Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners

Female partner experiences of prostate cancer patients’ engagement with a community-based football intervention: a qualitative study

The validity of the Distress Thermometer in female partners of men with prostate cancer

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