Predictors of Left Ventricular Function Deterioration in Patients With Left Bundle Branch Block and Ejection Fraction &gt;50%

Angheloiu, George O.; Saul, Melissa; Edelman, Kathy; Shah, Hemal; Mezu, Ure; Saba, Samir

doi:10.1111/chf.12028

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…In patients receiving pacemakers, there is a concern about the long‐term effects of non‐physiological right ventricular pacing. Although significant ventricular dysfunction in unselected patients develops rarely, 264 the main predictors of this unfavourable outcome include LVH and heart failure 265 . Two‐year data from the PACE trial suggest that biventricular pacing for bradycardia in patients with preserved ejection fraction may lead to more favourable outcomes as compared to right ventricular pacing alone 266 .…”

Section: Management Of Cardiac Complicationsmentioning

confidence: 99%

An expert consensus document on the management of cardiovascular manifestations of Fabry disease

Linhart

Germain

Olivotto

et al. 2020

European J of Heart Fail

131

119

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Fabry disease (FD) is an X-linked lysosomal storage disorder caused by pathogenic variants in the-galactosidase A (GLA) gene that leads to reduced or undetectable-galactosidase A enzyme activity and progressive accumulation of globotriaosylceramide and its deacylated form globotriaosylsphingosine in cells throughout the body. FD can be multisystemic with neurological, renal, cutaneous and cardiac involvement or be limited to the heart. Cardiac involvement is characterized by progressive cardiac hypertrophy, fibrosis, arrhythmias, heart failure and sudden cardiac death. The cardiac management of FD requires specific measures including enzyme replacement therapy or small pharmacological chaperones in patients carrying amenable pathogenic GLA gene variants and more general management of cardiac symptoms and complications. In this paper, we summarize current knowledge of FD-related heart disease and expert consensus recommendations for its management.

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Section: Management Of Cardiac Complicationsmentioning

confidence: 99%

An expert consensus document on the management of cardiovascular manifestations of Fabry disease

Linhart

Germain

Olivotto

et al. 2020

European J of Heart Fail

131

119

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“…Thus, achieving the LVEF values ≤ 40% in patients with an initial EF of > 50% was considered as LVEF deterioration. LVEF was visually estimated in the apical 4- and 2-chamber views ( 11 ).…”

Section: Methodsmentioning

confidence: 99%

Clinical Determinants of Left Ventricular Ejection Fraction Deterioration in Patients Suffered From Complete Left Bundle Branch Block

Jazi

Nilforoush

Gharipour

et al. 2014

Iran Red Crescent Med J

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Background:Recently, the deleterious effects of left bundle branch block (LBBB) on left ventricular systolic function have been taken into consideration.Objectives:The present study aimed to identify underlying factors that predict left ventricular ejection fraction (LVEF) deterioration in patients suffered from complete LBBB.Patients and Methods:In a retrospective case-control study, the data of 220 consecutive patients diagnosed with LBBB on their electrocardiograms were assessed. They were referred to Isfahan Heart Center in Isfahan Province, Iran in 2013. LVEF deterioration was defined as a decrease in LVEF at least 10% between the baseline and follow-up echocardiography study. Thus, achieving the LVEF values ≤ 40% in patients with an initial EF of > 50% was considered LVEF deterioration.Results:Among 220 patients, 40% of LBBB patients suffered LVEF deterioration within 3 months of initial assessment. The group with LVEF deterioration had higher male to female ratio, had higher NYHA score, and suffered more from systolic hypertension than another group. Those with coronary artery disease (CAD) had also significantly lower LVEF than non-CAD ones. Adverse associations were revealed between systolic blood pressure and LVEF measurement (r = -0.193, P = 0.006) as well as between NYHA score and LVEF (r = -0.215, P = 0.002). A multivariable logistic regression model showed that among baseline variables, male gender (OR = 3.218, P < 0.001), history of systolic hypertension (OR = 2.012, P = 0.029), higher NYHA score (OR = 1.623, P = 0.005), and the presence of coronary artery disease (OR = 2.475, P = 0.028) could effectively predict LVEF deterioration in patients with LBBB.Conclusions:Male gender, history of hypertension, high NYHA score, and the presence of CAD predict LVEF deterioration in patients with LBBB.

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“…least the theoretical basis for surveillance monitoring for the development of LBBB-induced cardiomyopathy (Angheloiu et al, 2013;Vaillant et al, 2013). Once LBBB develops, women may need more vigilant evaluations at shorter QRS durations.…”

Section: American College Of Cardiology Foundation and American Heartmentioning

confidence: 99%

Sex‐specific clinical outcomes after cardiac resynchronization therapy in left bundle branch block‐associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy

Wang

Mezu-Chukwu

Adelstein

et al. 2019

Noninvasive Electrocardiol

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Background: Sex differences in clinical outcomes for left bundle branch block (LBBB)associated idiopathic nonischemic cardiomyopathy (NICM) after cardiac resynchronization therapy (CRT) are not well described. Methods: A retrospective cohort study at an academic medical center included subjects with LBBB-associated idiopathic NICM who received CRT. Cox regression analyses estimated the hazard ratios (HRs) between sex and clinical outcomes. Results: In 123 total subjects (mean age 62 years, mean initial left ventricular ejection fraction 22.8%, 76% New York Heart Association class III, and 98% CRT-defibrillators), 55 (45%) were men and 68 (55%) were women. The median follow-up time after CRT was 72.4 months. Similar risk for adverse clinical events (heart failure hospitalization, appropriate implantable cardioverter-defibrillator shock, appropriate antitachycardia pacing therapy, ventricular assist device implantation, heart transplantation, and death) was observed between men and women (HR, 1.20; 95% confidence interval [CI] 0.57-2.51; p = 0.63). This persisted in multivariable analyses. Men and women had similar risk for all-cause mortality in univariable analysis, but men had higher risk in the final multivariable model that adjusted for age at diagnosis, QRS duration, and left ventricular end-diastolic dimension index (HR, 4.55; 95% CI, 1.26-16.39; p = 0.02). The estimated 5-year mortality was 9.5% for men and 6.9% for women. Conclusions: In LBBB-associated idiopathic NICM, men have higher risk for all-cause mortality after CRT when compared to women. K E Y W O R D S cardiac resynchronization therapy, clinical outcomes, left bundle branch block, nonischemic cardiomyopathy, sex-specific How to cite this article: Wang NC, Mezu-Chukwu U, Adelstein EC, et al. Sex-specific clinical outcomes after cardiac resynchronization therapy in left bundle branch block-associated idiopathic nonischemic cardiomyopathy: A

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Predictors of Left Ventricular Function Deterioration in Patients With Left Bundle Branch Block and Ejection Fraction >50%

Cited by 8 publications

References 14 publications

An expert consensus document on the management of cardiovascular manifestations of Fabry disease

An expert consensus document on the management of cardiovascular manifestations of Fabry disease

Clinical Determinants of Left Ventricular Ejection Fraction Deterioration in Patients Suffered From Complete Left Bundle Branch Block

Sex‐specific clinical outcomes after cardiac resynchronization therapy in left bundle branch block‐associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy

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