Predictors of Intellectual Function After a Unilateral Cortical Lesion: Study of 635 Patients From Infancy to Adulthood

Montour-Proulx, Isabelle; Braun, Claude M. J.; Daigneault, Sylvie; Rouleau, Isabelle; Kuehn, Sally M.; Bégin, Jean

doi:10.1177/08830738040190120501

Cited by 24 publications

(20 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 Yet, reported lateralized cognitive deficits after perinatal or childhood stroke are inconsistent, as the outcomes of perinatal stroke are largely dependent on the specific location (cortical, subcortical, or combined) affected structures and lesion severity. 15,43,45 -48 Interestingly, degree of asymmetry accounted for approximately 30% of the variance in cognitive ability observed among study participants. This suggests the relationship between asymmetry of deep medullary vein thrombosis and infarction and cognitive ability needs to be explored further.…”

Section: Discussionmentioning

confidence: 90%

Deep Medullary Vein White Matter Injury Global Severity Score Predicts Neurodevelopmental Impairment

Benninger

Moore‐Clingenpeel

et al. 2021

J Child Neurol

View full text Add to dashboard Cite

Aim: To examine associations between the deep medullary vein white matter injury global severity scoring system and neurodevelopmental impairment. Methods: This is a prospective observational cohort study of infants born at ≥32 weeks, diagnosed with deep medullary vein thrombosis and infarction on neuroimaging in the first month of life. Developmental testing was performed using validated measures for early, preschool, and school-age follow-up. Results: Nineteen (37%) patients had major neurodevelopmental impairment. Global severity score was higher among patients with neurodevelopmental impairment (21.6 vs 13.4, P = .04). Overall, 78% of patients with epilepsy had neurodevelopmental impairment. A greater degree of asymmetry with right-sided injury predominance was associated with lower Bayley-III cognitive scores and presence of neurodevelopmental impairment ( P < .01). Conclusions: Results suggest a need for targeted clinical surveillance for patients with a high global severity score and/or asymmetric, predominantly right cerebral white matter injury and for those who develop epilepsy.

show abstract

Section: Discussionmentioning

confidence: 90%

Deep Medullary Vein White Matter Injury Global Severity Score Predicts Neurodevelopmental Impairment

Benninger

Moore‐Clingenpeel

et al. 2021

J Child Neurol

View full text Add to dashboard Cite

show abstract

“…Hence, there was no evidence for the group to systematically "catch up" or "fall behind" over the course of development. This is consistent with findings from some researchers (Montour-Proulx et al, 2004;Westmacott et al, 2010) who found that cognitive outcomes were not related to age at testing;…”

Section: Patterns Of Achievement Across Lesion Variablessupporting

confidence: 92%

“…There have been mixed findings regarding the role of lesion severity on cognitive outcomes, with many studies finding a relationship between larger lesion size and greater impairment (Montour-Proulx et al, 2004;Vargha-Khadem, Isaacs, & Muter, 1994),…”

Section: Patterns Of Achievement Across Lesion Variablesmentioning

confidence: 99%

Academic achievement following childhood onset brain injury

Grafft¹

View full text Add to dashboard Cite

The degree of academic achievement following early onset brain injury is poorly understood. Furthermore, it is unclear if academic success can be predicted by age of onset or other lesion variables (e.g., size, laterality). The purpose of the current study was to describe patterns of academic achievement in individuals with childhood-onset focal brain lesions and to determine the role of variables in the plasticity or vulnerability of the developing brain with regard to achievement. Academic achievement data were collected from 58 individuals with childhood-onset focal brain lesions. The participants' reading, spelling, and arithmetic scores, as measured by the Wide Range Achievement Test, were analyzed in relation to several neuroanatomical variables, including lesion laterality, lesion site, and lesion size. The relationship between achievement and gender, age of onset, etiology, age at testing, and time since lesion onset was also identified. As a group, participants' achievement scores did not differ from normative data, and the majority of the sample demonstrated adequate skills in each domain. However, the frequency of deficits was larger than expected when compared to base rates, suggesting vulnerability to early insult. Achievement scores were correlated with intelligence scores, but did not differ based on lesion laterality, lesion site, age of onset, or etiology. Size of lesion was significantly correlated with reading and spelling but not with arithmetic outcomes. Gender differences were identified, with males performing significantly better on the arithmetic measure than females. The age of onset, age at testing, and time since lesion onset were not correlated with achievement scores in any domain. No interactions were found between lesion laterality and gender or lesion site and lesion laterality. An interaction between gender and lesion site was found, but the significance of the finding was unclear. The current findings provide mixed evidence for the plasticity-vulnerability debate, as many individuals were able to achieve adequate academic skills whereas others demonstrated significant impairments. Further research is Relationship Between Intelligence and Achievement in Poor and Good Achievement Groups .

show abstract

“…Conversely, it is now well-established that high order cognitive function is indeed modulated by age at lesion onset across the lifespan, particularly the first years of life, and that effect presents itself as an early vulnerability effect [45][46][47][48][49][50][51]. This effect has even been demonstrated with a large sample of brain lesioned children with the same task (c.f., RLAS) as the one used in the present investigation [52].…”

Section: Hypothesesmentioning

confidence: 99%

Evidence from unilateral lesions of early uncompensable implementation of opposed response-biases in each hemisphere of the brain

Guimond

Braun

Daigneault

et al. 2013

Journal of Pediatric Rehabilitation Medicine

Self Cite

View full text Add to dashboard Cite

PURPOSE: The intact right hemisphere presents an omissive response-bias and the left hemisphere a commissive response-bias in adults. This research sought to determine whether these hemispherically lateralized response-biases manifest early developmental and uncompensable brain implementation. METHODS: Sixteen teenager and adult participants with focal left hemisphere lesions and fourteen with focal right hemisphere lesions (all with childhood onset: M = 13 year recovery period) and 14 normal control participants were recruited. A computerized multitask high order working memory procedure was designed to generate many errors of omission and of commission. RESULTS: The expected double dissociation of response-bias distortion as a function of lesion side was significantly demonstrated on this task and was significantly frontal-lobe dependent. CONCLUSION: The hemispheres of the brain have an opposed response bias that is robustly implemented in infancy through adulthood.

show abstract

Predictors of Intellectual Function After a Unilateral Cortical Lesion: Study of 635 Patients From Infancy to Adulthood

Cited by 24 publications

References 55 publications

Deep Medullary Vein White Matter Injury Global Severity Score Predicts Neurodevelopmental Impairment

Deep Medullary Vein White Matter Injury Global Severity Score Predicts Neurodevelopmental Impairment

Academic achievement following childhood onset brain injury

Evidence from unilateral lesions of early uncompensable implementation of opposed response-biases in each hemisphere of the brain

Contact Info

Product

Resources

About