Predictors of Incident Chronic Widespread Pain Among Veterans Following the First Gulf War

Ang, Dennis C.; Peloso, Paul M.; Woolson, Robert F.; Kroenke, Kurt; Doebbeling, Bradley N.

doi:10.1097/01.ajp.0000208907.42506.21

Cited by 30 publications

(24 citation statements)

References 69 publications

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“…All traces represent the same neuron. E) Although the effects on V 1/2 were reduced, permethrin shifted Fukuda et al, 1998;Proctor et al, 1998;Gray et al, 1999;Kang et al, 2000;Steele et al, 2000;Gray et al, 2002;Voelker et al 2002;Ang et al, 2006). When these, and other reports, were subjected to meta-analysis, it was confirmed that those who served in the Persian Gulf theatre were more likely to suffer from a variety chronic pain conditions.…”

Section: Discussionmentioning

confidence: 81%

“…Many of the types of pain reported by veterans would be considered tonic rather than evoked pain (Escalante and Fischbach, 1998;Proctor et al, 1998;Fukuda et al, 1998;Gray et al, 1999;Kang et al, 2000;Steele et al, 2000;Gray et al, 2002;Voelker et al 2002;Ang et al, 2006). K v 7 channel proteins play an important role in neuronal spontaneous discharge ).…”

Section: Discussionmentioning

confidence: 99%

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Synergistic Actions of Pyridostigmine Bromide and Insecticides on Muscle and Vascular Nociceptors

Cooper¹

2013

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)July 2013 (From -To) 15 5e. TASK NUMBER 5f. WORK UNIT NUMBER REPORT TYPE Annual DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) University of Florida AND ADDRESS(ES) PERFORMING ORGANIZATION REPORT NUMBERGainesville, Fl 32611-5500 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and MaAnd Material Command Fort Detrick, Maryland SPONSOR/MONITOR'S REPORT 21702-5012 NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for public release: distribution unlimited SUPPLEMENTARY NOTES ABSTRACTWe examined whether chronic exposure to combinations of two neurotoxicants (chlorpyrifos and permethrin) with pyridostigmine bromide (PB) could produce a delayed neuropathic pain condition in rats; and whether corresponding molecular changes would occur in nociceptive neurons coding for pain in skin, muscle or vasculature. Following a 60 day exposure to neurotoxicants/PB (NTPB), we observed molecular dysfunctions in membrane Kv (Kv7) and Nav (Nav1.8, Nav1.9) proteins that persisted 8 weeks after exposure had ended. Functional changes (spontaneous activity, action potential duration) were also documented. Most of the maladaptations were present in vascular nociceptors. The physical location of vascular nociceptive neurons renders them most exposed to concentrations of circulating neurotoxicants/PB as well as to any blood borne secondary influences (endocrine, immune) these agents might induce. As a result, vascular nociceptors could be the first nervous system component damaged by neurotoxicants/PB. An imbalance between Kv 7 and other Na + channel proteins (Nav1.9) could prove to be a basis for a chronic pain condition sourced from a vulnerable subset of vascular nociceptors. A resulting neurovascular reflex dysfunction could cause widespread pain and also contribute to the development of CNS symptoms that have been identified in Gulf War veterans. . The events leading to the development of GWI pain are unknown, but it has been reported that the use of pyridostigmine bromide (PB) and a variety of insecticides/repellants co-var...

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Synergistic Actions of Pyridostigmine Bromide and Insecticides on Muscle and Vascular Nociceptors

Cooper¹

2013

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“…18,39 This cohort has been well characterized and the methods validated in a series of manuscripts. 3,6,[8][9][10][11]17,22,35,36,41,44 …”

Section: Methodsmentioning

confidence: 99%

Chronic Widespread Pain in Veterans of the First Gulf War: Impact of Deployment Status and Associated Health Effects

Forman‐Hoffman

Peloso

Black

et al. 2007

The Journal of Pain

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“…Trafton, Ilgen, and their colleagues reported on a series of studies that investigated the role of persistent pain as a moderator of effective treatment for opioiddependent veterans [15][16][17]. Predictors of chronic widespread pain among veterans of the first Gulf War have been identified as family history of unexplained symptoms, predeployment symptoms, and level of perceived stress [18]. Results of a VHA Cooperative Study designed to examine the effects of cognitivebehavioral therapy and aerobic exercise on Gulf War veterans' illnesses, a complex problem that includes the presence of diffuse musculoskeletal pain, have also been reported [19].…”

Section: Peer-reviewed Publicationsmentioning

confidence: 99%

Veterans Health Administrations pain research portfolio and publications

Elnitsky¹,

Bryan²,

Kerns³

2007

JRRD

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Predictors of Incident Chronic Widespread Pain Among Veterans Following the First Gulf War

Abstract: Among the GW veterans evaluated longitudinally in this study, family history, predeployment symptoms, and the level of perceived stress during the GW were associated with subsequent development of CWP.

Cited by 30 publications

References 69 publications

Synergistic Actions of Pyridostigmine Bromide and Insecticides on Muscle and Vascular Nociceptors

Synergistic Actions of Pyridostigmine Bromide and Insecticides on Muscle and Vascular Nociceptors

Chronic Widespread Pain in Veterans of the First Gulf War: Impact of Deployment Status and Associated Health Effects

Veterans Health Administrations pain research portfolio and publications

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