Predictors of histology, tissue eosinophilia and mast cell infiltration in Hodgkin’s Lymphoma - a population-based study

Glimelius, Ingrid; Rubin, Jenny; Rostgaard, Klaus; Amini, Rose‐Marie; Simonsson, Martin; Sørensen, Karina Meden; Smedby, Karin E.; Hjalgrim, Henrik; Molin, Daniël; Enblad, Gunilla

doi:10.1111/j.1600-0609.2011.01652.x

Cited by 24 publications

(24 citation statements)

References 31 publications

(40 reference statements)

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“…Our results were consistent with previous epidemiological studies that showed TATE was associated with a good prognosis in colon cancer (4-7), because we showed that human eosinophils induced death in Colo-205 cells. In contrast, TATE was associated with a poor prognosis in Hodgkin's lymphoma (39,40). This observation was consistent with our finding that eosinophils did not appear to be cytotoxic against L428 cells, a Hodgkin's lymphoma cell line.…”

Section: Discussionsupporting

confidence: 87%

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

Gatault

Delbeke

Driss

et al. 2015

The Journal of Immunology

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Eosinophils are multifunctional leukocytes that are involved in innate and adaptive immune responses through the expression of various receptors and mediators. Previously, we showed that human eosinophils and T cells shared cytotoxic activities against tumor cells that involved the γ-δ TCR and cell–cell contact. In this study, we investigated the molecules involved in eosinophil–tumor cell interactions. Given the role of IL-18 in cell adhesion and in protecting against colon cancer, we evaluated its role in eosinophil-mediated cytotoxicity against Colo-205, a human colon carcinoma cell line. We found that human eosinophils exerted dose- and time-dependent tumoricidal activity against Colo-205 cells. Neutralization of IL-18 significantly reduced eosinophil-mediated Colo-205 apoptosis and inhibited cell–cell adhesion. Moreover, addition of rIL-18 led to upregulation of CD11a and ICAM-1 adhesion molecules, which were involved in the contact between eosinophils and Colo-205 cells. Our results indicated that IL-18 was involved in the eosinophil-mediated death of Colo-205 by facilitating contact between effector and target cells. These data underscored the involvement of an additional mediator in eosinophil-mediated antitumor cytotoxicity. Our findings support existing evidence that eosinophils could play a beneficial role in the context of colon cancer.

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Section: Discussionsupporting

confidence: 87%

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

Gatault

Delbeke

Driss

et al. 2015

The Journal of Immunology

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“…28 On the other hand, some authors reported that NSCHL correlated with higher numbers of tumor-infiltrating mast cells, compared with non-NSCHL. [29][30][31] Immunodeficient NOD/SCID mice inoculated with both mast cells and human HRS cells grew tumors with a more marked fibrotic component, compared with tumors in mice inoculated with HRS cells alone. 32 Thus, there is mounting evidence that the fibrosis observed in association with mast cells in NSCHL is primarily a consequence of the mast cell infiltration, rather than the cause.…”

Section: Discussionmentioning

confidence: 99%

Role of mast cells in fibrosis of classical Hodgkin lymphoma

Nakayama

Yokote

Hiraoka

et al. 2016

Int J Immunopathol Pharmacol

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The underlying mechanism of fibrosis in classical Hodgkin lymphoma (CHL) remains uncertain. This study aimed to investigate the association of fibrosis in the lymph nodes of patients with CHL through histological examination of the expression of cytokines associated with fibrosis and mast cell proliferation. Additionally, we sought to determine the degree of mast cell infiltration in a nodular sclerosis subtype of CHL (NSCHL) compared with that in non-NSCHL. We analyzed lymph nodes from 22 patients with CHL, of which eight were of the NSCHL and 14 of the non-NSCHL subtype, using immunohistochemical staining of forkhead box P3 (FOXP3), transforming growth factor (TGF)-β, interleukin (IL)-3, IL-13, and stem cell factor (SCF). Mast cells were positive for TGF-β and IL-13, and FOXP3-positive cells were negative for TGF-β. Only the expression of IL-13 in Hodgkin and Reed-Sternberg (HRS) cells was significantly more frequently observed in NSCHL than that in non-NSCHL (P = 0.0028) and was associated with a higher rate of fibrosis (P = 0.0097). The number of mast cells was significantly higher in NSCHL than that in non-NSCHL (P = 0.0001). A significantly positive correlation was observed between the rate of fibrosis and the number of mast cells (correlation coefficient, 0.8524; 95% CI, 0.6725-0.9372) (P <0.0001). The number of mast cells was significantly higher in the group with IL-13-positive HRS cells than that in the group with IL-13-negative HRS cells (P = 0.0157). Based on these findings, we hypothesize that IL-13 production by HRS cells may lead to fibrosis, and furthermore, promote mast cell proliferation and infiltration. This in turn might further produce the fibrotic cytokines IL-13 and TGF-β, resulting in fibrosis typical of NSCHL.

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“…32,33 In HL, the tumor microenvironment, which represents 99% of the tumor, comprises reactive cells that help maintain an inflammatory milieu, 34 and individual traits affect the tumor microenvironment in HL. 35 UVR appears to induce regulatory T cells through antigen presentation by UVR-damaged Langerhans cells in the lymph nodes 36 leading to an immunosuppressed state that may be protective, as suggested by the inverse association observed between the use of aspirin and HL risk. [37][38][39] Second, the cellular DNA damage response activated by viral oncogenes such as those associated with EBV 40 could cause tumor suppression by effector T cells when enhanced by UVR exposure, 41 which is known to induce multiple defense mechanisms to counterbalance its potential mutagenic and cytotoxic effects.…”

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confidence: 99%

Exposure to UV radiation and risk of Hodgkin lymphoma: a pooled analysis

Monnereau

Glaser

Schupp

et al. 2013

Blood

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• Our pooled analysis found an inverse association between several measures of UVR exposure and Hodgkin lymphoma. • Significant UVR-related inverse associations of EBV-positive HL with a doseresponse relationship support etiologic heterogeneity in HL.Ultraviolet radiation (UVR) exposure has been inversely associated with Hodgkin lymphoma (HL) risk, but only inconsistently, only in a few studies, and without attention to HL heterogeneity. We conducted a pooled analysis of HL risk focusing on type and timing of UVR exposure and on disease subtypes by age, histology, and tumor-cell Epstein-Barr virus (EBV) status. Four case-control studies contributed 1320 HL cases and 6381 controls. We estimated lifetime, adulthood, and childhood UVR exposure and history of sunburn and sunlamp use. We used 2-stage estimation with mixed-effects models and weighted pooled effect estimates by inverse marginal variances. We observed statistically significant inverse associations with HL risk for UVR exposures during childhood and adulthood, sunburn history, and sunlamp use, but we found no significant doseresponse relationships. Risks were significant only for EBV-positive HL (pooled odds ratio, 0.56; 95% confidence interval, 0.35 to 0.91 for the highest overall UVR exposure category), with a significant linear trend for overall exposure (P 5 .03). Pooled relative risk estimates were not heterogeneous across studies. Increased UVR exposure may protect against HL, particularly EBV-positive HL. Plausible mechanisms involving UVR induction of regulatory T cells or the cellular DNA damage response suggest opportunities for new prevention targets. (Blood. 2013;122(20):3492-3499)

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Predictors of histology, tissue eosinophilia and mast cell infiltration in Hodgkin’s Lymphoma - a population-based study

Abstract: The number of eosinophils in HL tumours is influenced by patient traits such as asthma, ECP genotype and EBV status. EBV status was predictive of histology.

Cited by 24 publications

References 31 publications

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

IL-18 Is Involved in Eosinophil-Mediated Tumoricidal Activity against a Colon Carcinoma Cell Line by Upregulating LFA-1 and ICAM-1

Role of mast cells in fibrosis of classical Hodgkin lymphoma

Exposure to UV radiation and risk of Hodgkin lymphoma: a pooled analysis

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