Predictors of High-Risk Adenoma Occurrence at Surveillance Colonoscopy in Patients Who Undergo Colorectal Adenoma Removal

Liu, Jin; Seo, Jinho; Sim, Ho Chan; Choi, Joon Hyuk; Heo, Nae–Yun; Park, Jongha; Park, Seung Ha; Moon, Young Soo; Kim, Tae-Oh

doi:10.1159/000489925

Cited by 5 publications

(4 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Potentially, a longer follow-up would increase the number of events in this category and a significant association would be found as expected. This factor is considered a main quality indicator for the colonoscopy procedure and was associated with subsequent CRC in other studies (Lieberman et al 2000;Amano et al 2018;Lee et al 2018). If no polyps were found, a risk for CRC remained.…”

Section: Discussionmentioning

confidence: 99%

Colonoscopy and polypectomy: beside age, size of polyps main factor for long-term risk of colorectal cancer in a screening population

Halfter

Bauerfeind

Schlesinger-Raab

et al. 2021

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Purpose Despite national and international guideline recommendations, few studies have been conducted to estimate the impact of colonoscopy screening on long-term colorectal cancer incidence. Aim of this study was to determine the long-term impact of a full colonoscopy with polypectomy on colorectal cancer incidence in a large screening population. Methods In this prospective observational cohort study, a total of 10,947 colonoscopy screening participants from within the scope of the Munich Cancer Registry were consecutively recruited from participating gastroenterology practices and their subsequent colorectal cancer incidence assessed. Predictive factors associated with colorectal cancer were also evaluated in univariate and multivariate analyses. Results After a median follow-up of 14.24 years (95% CI [14.21–14.25]), 93 colorectal cancer cases were observed. This is equivalent to a truncated age-standardized rate of 69.0 (95% CI [43.3–94.7]) for male and 43.4 (95% CI [29.4–57.5]) for female participants (≥ 50 years at colonoscopy). The ratio of this observed to the expected rate from cancer registry data showed a 67% decrease in colorectal cancer incidence in the male and 65% in the female participants (p < 0.0001). In multivariate analysis of screening patients, age at screening (p < 0.0001) was the main predictive factor for colorectal cancer. In the subgroup with positive polyp findings, age (p < 0.0001) and the polyp size (p = 0.0002) were associated with colorectal cancer. Conclusion These results underline the significance of a full colonoscopy screening combined with polypectomy in reducing the total disease burden of colorectal cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Colonoscopy and polypectomy: beside age, size of polyps main factor for long-term risk of colorectal cancer in a screening population

Halfter

Bauerfeind

Schlesinger-Raab

et al. 2021

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…Previous studies reported that colorectal adenomas exhibit an intriguing link with arterial stiffness, a well-known indicator of cardiovascular disease. [9][10][11][12][13] PWV is a direct indicator of arterial wall elasticity and the most traditional measure used to gauge the degree of vascular rigidity. On the other hand, it is dependent on the patient's blood pressure at the time of measurement.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported the relationship between peripheral vascular diseases and colorectal adenomas using ABI and PWV. [9][10][11][12] Additionally, a recent study reported an association of arterial stiffness measured by PWV with the occurrence of high-risk adenomas and serrated lesions. 13 However, no studies have assessed the association between CAVI and adenoma risk.…”

Section: 8mentioning

confidence: 99%

Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index

Lee,

Cho,

Lee

et al. 2024

Korean J Gastroenterol

View full text Add to dashboard Cite

Background/Aims: Colorectal adenomas are precancerous lesions that may lead to colorectal cancer. Recent studies have shown that colorectal adenomas are associated with atherosclerosis. The cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) are noninvasive methods for evaluating atherosclerosis. This study examined the association between atherosclerosis and high-risk colorectal adenomas based on the CAVI and ABI. Methods: The data of patients aged ≥50 years who had a colonoscopy and CAVI and ABI measurements from August 2015 to December 2021 at the Kangwon National University Hospital were analyzed retrospectively. After the colonoscopy, subjects were divided into no, overall, and high-risk (size ≥1 cm, high-grade dysplasia or villous adenoma, three or more adenomas) adenoma groups based on the pathology findings. The data were subjected to univariate and multivariate logistic regression analyses. Results: Among the 1,164 subjects, adenomas and high-risk adenomas were found in 613 (52.6%) and 118 (10.1%) patients, respectively. The rate of positive ABI (<0.9) and positive CAVI (≥9.0) were significantly higher in the high-risk adenoma group (22.0% and 55.9%) than in the no adenoma (12.3% and 39.6%) and the overall adenoma group (15.7% and 44.0%) (p=0.008 and p=0.006, respectively). Multivariate analysis revealed a positive CAVI and smoking status to be significantly associated with high-risk adenoma with an odds ratio of 1.595 (95% confidence interval 1.055-2.410, p=0.027) and 1.579 (1.072-2.324, p=0.021), respectively. Conclusions: In this study, a significant correlation between positive CAVI and high-risk adenomas was observed. Therefore, CAVI may be a significant predictor for high-risk colorectal adenoma.

show abstract

“…Although no significant differences were found in the risks of metachronous CRC between the 1-2 NAAs and 3-4 NAAs groups and between the 3-4 NAAs and $5 NAAs groups, there was a tendency to increase the risk between the 1-2 NAAs and 3-4 NAAs groups. Although polyps were not found, the risk for metachronous CRC remained; moreover, a longer follow-up could increase the incidence of CRC, and the main quality indicators of colonoscopy were associated with metachronous CRC (29)(30)(31)(32). Our metaanalysis did not include only studies that performed a qualified colonoscopy.…”

Section: Review Articlementioning

confidence: 99%

Risk of Metachronous Colorectal Advanced Neoplasia and Cancer in Patients With 3–4 Nonadvanced Adenomas at Index Colonoscopy: A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

INTRODUCTION:This systematic review and meta-analysis evaluated the available evidence on the risk of metachronous advanced neoplasia (AN) and colorectal cancer (CRC) in patients with 3–4 nonadvanced adenomas (NAAs).METHODS:We searched MEDLINE, EMBASE, and Cochrane Library databases up to January 2021 for studies evaluating metachronous AN and CRC risk by comparing 3 groups (1–2 vs 3–4 vs ≥5 NAAs) at index colonoscopy. The estimates for risk of metachronous AN and CRC were evaluated using random-effects models.RESULTS:Fifteen studies (n = 36,375) were included. The risk of metachronous AN was significantly higher in the 3–4 NAAs group than in the 1–2 NAAs group (relative risk [RR] 1.264, 95% confidence interval [CI] 1.053–1.518, P = 0.012; I2 = 0%); there was no difference between the ≥ 5 NAAs and 3–4 NAAs groups (RR 1.962, 95% CI 0.972–3.958, P = 0.060; I2 = 68%). The risks of metachronous CRC between the 1–2 NAAs and 3–4 NAAs groups (RR 2.663, 95% CI 0.391–18.128, P = 0.317; I2 = 0%) or the 3–4 NAAs and ≥ 5 NAAs groups (RR 1.148, 95% CI 0.142–9.290, P = 0.897; I2 = 0%) were not significantly different.DISCUSSION:Although the risk of metachronous AN was greater in the 3–4 NAAs group than in the 1–2 NAAs group, the risk of metachronous AN and CRC between the 3–4 NAAs and ≥ 5 NAAs groups was not different. This suggests that further studies on metachronous AN and CRC risk in the 3–4 NAAs group are warranted to confirm a firm ≥5-year interval surveillance colonoscopy.

show abstract

Predictors of High-Risk Adenoma Occurrence at Surveillance Colonoscopy in Patients Who Undergo Colorectal Adenoma Removal

Cited by 5 publications

References 34 publications

Colonoscopy and polypectomy: beside age, size of polyps main factor for long-term risk of colorectal cancer in a screening population

Colonoscopy and polypectomy: beside age, size of polyps main factor for long-term risk of colorectal cancer in a screening population

Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index

Risk of Metachronous Colorectal Advanced Neoplasia and Cancer in Patients With 3–4 Nonadvanced Adenomas at Index Colonoscopy: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About