“…The specific characteristics of the population frame of reference are an important metric. For example, significant effects on infant size for age are due to factors ranging from genetic predisposition to biological age (gestational age in young infants) (Casey et al, 1991), feeding style (Dewey, 1998), illness (Waterlow, 1994), and altitude (Haas et al, 1982), in addition to broader lifestyle variables such as socioeconomic level (Victora et al, 1987) and maternal education (Lartey et al, 2000), as these mediate availability to the infant of resources ranging from nutrition to health care. Thus a conclusion of ''small for age,'' ''large for age,'' or ''appropriate for age'' for any single individual is entirely contingent on the nature of the comparative framework.…”