Infertility is defined as failure to achieve clinical pregnancy after 12 months of regular sexual intercourse. 1 Emotional stress related to infertility has been shown to impair quality of life (QoL) and could play an important role in successful infertility treatment. 2To understand the burden of emotional stress, the QoL of couples experiencing infertility was examined from a dyadic perspective, and the factors affecting the QoL of men and women were evaluated comparatively.board provided ethical approval prior to data collection and informed consent was obtained from all participants. A structured questionnaire was used to obtain demographic information known to be relevant based on previous study data. 3 The FertiQoL, an internationally developed instrument for measuring infertility-specific QoL in people experiencing infertility, 4 was used to evaluate the QoL of participants, with higher scores for any subdomain indicating better QoL. FertiQoL scores were considered to be dependent variables in the present study, with all other parameters considered independent variables.Statistical analyses were performed using SPSS version 16.0 (SPSS, Chicago, IL, USA). A two-way analysis of variance test was used to examine the influence of different categorical independent variables on FertiQoL scores, with the results stratified by gender; P<0.05 was considered statistically significant.In total, 202 couples were enrolled in the present study. The age range was 24-35 years for female participants and 28-39 years for male participants. The mean±SD duration of infertility experienced by participants was 5.0±4.9 years. The incidence of receiving psychological support (34 of 200 [17.0%] women responding vs 13 of 197 [6.6%] men responding; P=0.001) and desiring psychological support (33 of 202 [16.3%] women responding vs 13 of 198 [6.6%] men responding; P=0.003) were significantly higher among female participants, and emotional (P=0.001) and mind/body (P=0.006) FertiQoL scores were significantly lower among female participants. Two-way analysis of variance tests were used to analyze the effects of age, education, employment status, health insurance, income level, receiving psychological support, desiring psychological support, and infertility cause on the FertiQoL scores; the results were stratified by gender (Table 1). Higher emotional and mind/body FertiQoL subscale scores were recorded among male participants who were in employment in comparison with female participants (P=0.003) and compared with male participants who were unemployed (P=0.005).The present results demonstrated that, among couples experiencing infertility, QoL was higher in male participants compared with their partners; however, being unemployed was associated with decreased QoL among male participants. Female participants were more likely to utilize psychological support and to report desiring psychological support. Consequently, individualized counselling methods could be applied to individuals among couples experiencing infertility.