Predictors of falls and fractures leading to hospitalization in people with schizophrenia spectrum disorder: A large representative cohort study

Stubbs, Brendon; Mueller, Christoph; Gaughran, Fiona; Lally, John; Vancampfort, Davy; Lamb, Sarah E; Koyanagi, Ai; Sharma, Shalini; Stewart, Robert; Perera, Gayan

doi:10.1016/j.schres.2018.05.010

Cited by 27 publications

(24 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The cohort included all individuals aged 18 years or older with a diagnosis of SSD (ICD-10: F20-F29) and had at least one face to face contact with SLaM during the period between 1 st January 2011 and 31 st December 2012, and who were alive on 1 st January 2013 (set up in this way to allow all cases to have at least 5 year follow-up). In recognition of the heterogeneous nature of schizophrenia, we included the spectrum of schizophrenia (SSD) as in accordance with previous research papers (Chang et al, 2010;Stubbs, Mueller, et al, 2018). We used primary and secondary diagnoses of F20-29 within the structured ICD-10 codes that were recorded routinely in the source EHR.…”

Section: Study Populationmentioning

confidence: 99%

Association of physical health multimorbidity with mortality in people with schizophrenia spectrum disorders: Using a novel semantic search system that captures physical diseases in electronic patient records

Kugathasan

Gaughran

et al. 2020

Schizophrenia Research

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Study Populationmentioning

confidence: 99%

Association of physical health multimorbidity with mortality in people with schizophrenia spectrum disorders: Using a novel semantic search system that captures physical diseases in electronic patient records

Kugathasan

Gaughran

et al. 2020

Schizophrenia Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…33,34 Falls risk in latelife psychotic disorders has received very little investigation, although recent cohort studies have suggested that this population is at increased risk of fractures. 35,36 A recent systematic review suggested that people with depressive symptoms are at increased risk of hip fractures, although relatively few (n ¼ 5) studies included people with confirmed depression. 37 A meta-analysis suggested that people with major depression were at increased risk of future falls, but the sample size was small (n ¼ 965).…”

mentioning

confidence: 99%

Risk of Hospitalized Falls and Hip Fractures in 22,103 Older Adults Receiving Mental Health Care vs 161,603 Controls: A Large Cohort Study

Stubbs

Perara

Koyanagi

et al. 2020

Journal of the American Medical Directors Association

Self Cite

View full text Add to dashboard Cite

Objectives: To investigate the risk of hospitalized fall or hip fracture among older adults using mental health services. Design: Retrospective cohort study. Setting and Participants: Residents of a South London catchment aged >60 years receiving specialist mental health care between 2008 and 2016. Measures: Falls and/or a hip fracture leading to hospitalization were ascertained from linked national records. Incidence rates and incidence rate ratios (IRRs) were age-and gender-standardized to the catchment population. Multivariable survival analyses were applied investigating falls and/or hip fractures as outcomes. Results: In 22,103 older adults, incidence rates were 60.1 per 1000 person-years for hospitalized falls and 13.7 per 1000 person-years for hip fractures, representing standardized IRRs of 2.17 [95% confidence interval (CI) 2.07-2.28] and 4.18 (3.79-4.60), respectively. The IRR for falls was high in those with substance-use disorder [IRR ¼ 6.72 (5.35-8.33)], bipolar disorder [IRR ¼ 3.62 (2.50-5.05)], depression [IRR ¼ 2.28 (2.00-2.59)], and stress-related disorders [IRR ¼ 2.57 (2.10-3.11)]. Hip fractures were increased in all populations (IRR > 2.5), with greatest risk in substance use disorders )], dementia .00)], and delirium [IRR ¼ 4.03 (3.00-5.29)]. Comparing mental disorder subgroups with each other, after the adjustment for 25 potential confounders, patients with dementia and substance use had a significantly increased risk of falls, and patients with dementia also had an increased risk of hip fractures. Conclusion and Implications: Older people using mental health services have more than double the incidence of falls and 4 times the incidence of hip fractures compared to the general population. Although incidences differ between diagnostic subgroups, all groups have a higher incidence than the The authors declare no conflicts of interest.

show abstract

“…Las condiciones patológicas que alteran el pensamiento prolongan la estadía de los pacientes (8)(9)(10)(11)21); en este sentido, en el presente estudio, una estancia mayor a 8 días s identificó como un factor que aumenta el riesgo de caídas (OR=4.51 (3.23-6.30)). Estas condiciones requieren como parte de su manejo la implementaciones de medidas de sujeción y sedación del paciente, las cuales también aumentan el riesgo de caídas que estos medicamentos pueden provocar efectos extrapiramidales y, e consecuencia, propiciar el evento caída (11).…”

Section: Discusión [T1]unclassified

Factores de riesgo asociados a las caídas intrahospitalarias en tres instituciones de Colombia

et al. 2020

View full text Add to dashboard Cite

Introducción. Las caídas intrahospitalarias son eventos adversos que se relacionan con múltiples factores de riesgo y que tienen implicaciones importantes para los pacientes y los sistemas de salud.Objetivo. Determinar los factores de riesgo asociados a las caídas intrahospitalarias en tres hospitales de tercer nivel de Colombia.Materiales y métodos. Estudio observacional analítico de casos y controles. La muestra mínima requerida fue de 270 casos y 270 controles (error alfa del 5%). Se incluyeron 690 pacientes y se analizaron 17 variables. El análisis de los datos se realizó mediante el cálculo del OR y el desarrollo de un modelo de regresión logística con un nivel de significancia del 5%.Resultados. Los factores de riesgo fueron tener catéter venoso periférico (OR: 2.92, IC95%: 1.01-8.43), contar con medidas de sujeción o sedación (OR: 2.35, IC95%: 1.11-4.97), tener una estancia hospitalaria mayor a ocho días (OR: 2.85, IC95%: 2.0-4.06), estar en tratamiento con medicamentos de alto riesgo (OR: 2.82, IC95%: 1.86-4.28), no contar con acompañante permanente (OR: 2.68, IC95%: 1.87-3.83) y, por último, ser un paciente no colaborador (OR: 1.61, IC95%: 0.84-3.0), variable sin significancia estadística, pero clínicamente relevante.Conclusión. Fue posible determinar factores de riesgo relacionados a las caídas intrahospitalarias que requieren ser abordados por estas tres instituciones para prevenir y disminuir la presentación de estos eventos adversos. Asimismo, otros hospitales del país pueden utilizar los resultados aquí reportados para mejorar el cuidado de sus pacientes y prevenir este fenómeno dentro de sus instalaciones.

show abstract

Predictors of falls and fractures leading to hospitalization in people with schizophrenia spectrum disorder: A large representative cohort study

Cited by 27 publications

References 46 publications

Association of physical health multimorbidity with mortality in people with schizophrenia spectrum disorders: Using a novel semantic search system that captures physical diseases in electronic patient records

Association of physical health multimorbidity with mortality in people with schizophrenia spectrum disorders: Using a novel semantic search system that captures physical diseases in electronic patient records

Risk of Hospitalized Falls and Hip Fractures in 22,103 Older Adults Receiving Mental Health Care vs 161,603 Controls: A Large Cohort Study

Factores de riesgo asociados a las caídas intrahospitalarias en tres instituciones de Colombia

Contact Info

Product

Resources

About