Predictors of Exclusive Breastfeeding for 6 Months in a National Sample of US Children

Stough, Cathleen Odar; Khalsa, Amrik Singh; Nabors, Laura; Merianos, Ashley L.; Peugh, James

doi:10.1177/0890117118774208

Cited by 45 publications

(31 citation statements)

References 37 publications

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“…Breastfeeding is highly recommended as the primary source of nutrients and bioactive molecules for neonates, and the American Academy of Pediatrics recommends breastfeeding for at least 6 months after birth. 24,25 However, many women who require medications are hesitant to nurse their infants and tend to reduce or discontinue breastfeeding earlier than women who are not receiving medication, or even refuse to breastfeed. To date, several studies have explored detectable drug levels in IBD mothers' breast milk, 6,21,26 and the general consensus is that breastfeeding by IBD mothers is safe.…”

Section: Discussionmentioning

confidence: 99%

The Profile of Human Milk Metabolome, Cytokines, and Antibodies in Inflammatory Bowel Diseases Versus Healthy Mothers, and Potential Impact on the Newborn

Meng

Dunsmore

Koleva

et al. 2018

Journal of Crohn's and Colitis

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Background and Aims: For women with inflammatory bowel disease [IBD], it is not very well known how IBD or IBD treatment affects their breast milk components. We aimed to investigate whether breast milk composition differs in healthy control [HC] versus IBD mothers in terms of antibodies, cytokines, and metabolite,s to identify potential impact of IBD breast milk on neonatal immune system. Methods: Breast milk specimens from HC [n = 17] and IBD [n = 31 for Crohn's disease [CD]; and n = 41 for ulcerative colitis [UC]; were collected at 3 and 6 months postpartum [PP3] and [PP6], respectively. Faecal samples were also collected. Cytokines and immunoglobulins [IgA/IgG/IgE] were analysed by multiplex Meso Scale Discovery [MSD] and commercial kits. Moreover, breast milk metabolites were analysed by 1 H nuclear magnetic resonance [NMR]. Results: We found that breast milk from IBD mothers showed significantly lower levels of IgA, sugar metabolite [lactose], and 2-aminobutyrate. In contrast, we observed that breast milk from mothers with IBD had increased levels of pro-inflammatory cytokines and higher energy metabolites [lactate and succinate] than milk from healthy mothers. In addition, we noticed that the type of treatment [5-aminosalicylic acid versus biologics] influenced the milk cytokines and metabolites profile. Conclusions: The reduction in immunoprotective components of IBD breast milk such as sIgA and lactose theoretically may modulate the potential protective effects of breastfeeding. On the other hand, presence of higher levels of pro-inflammatory cytokines, lactate, and succinate may predispose the offspring to an inflammatory condition or impact on the gut microbiome. Better understanding of the role of succinate in infants and its potential effects on microbiome or mucosal immunity merits further investigations.

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Section: Discussionmentioning

confidence: 99%

The Profile of Human Milk Metabolome, Cytokines, and Antibodies in Inflammatory Bowel Diseases Versus Healthy Mothers, and Potential Impact on the Newborn

Meng

Dunsmore

Koleva

et al. 2018

Journal of Crohn's and Colitis

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“…Previous studies have listed several factors associated with exclusive breastfeeding such as ethnicity of the mother 20 , maternal education 20 , 21 , family income 20 , perceived inadequate breast milk 21 , maternal age 22 , mode of delivery 21 and knowledge about EBF. 23 …”

Section: Introductionmentioning

confidence: 99%

Use of Haematological Changes as a Predictor of Dengue Infection among Suspected Cases at Kairuki Hospital in Dar Es Salaam, Tanzania: A Retrospective Cross Sectional Study

Kalabamu

Maliki²

2021

EAHRJ

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Background: Dengue is a viral disease transmitted by female Aedes mosquitoes which are commonly found in tropical and subtropical areas. There is a dramatic increase in annual incidence rate of dengue attributed to urbanisation, poor environmental management as well as increased people mobility. Outbreak of dengue have been reported in Tanzania in recent years with Dar es salaam being the most affected region. Dengue is associated with haematological derangements and itindicates the severity of the disease. These changes have not been well elucidated in Tanzanian patients. The aim of this study was to determine these derangements among dengue patients admitted at Kairuki hospital in Dar es salaam, and compare these changes with non- dengue febrile patients. Methods: A retrospective cross sectional study was conducted among patients who were suspected to have dengue; tested for dengue IgM and their Complete Blood Count were tested during the index illness. This information was obtained from Kairuki hospital laboratory database. Haematological parameters were compared between dengue and non-dengue patients using SPSS Version 20.0. Binary logistic regression analysis was used to determine haematological predictors of dengue positive results. Results: A total of 255 patients were enrolled, whereby 188(73.7%) were dengue positive and 67 (26.3%) were negative. Dengue patients had relatively low mean total white blood cell counts compared to non-dengue patients (Student’s test= -2.7; p value=.007). Furthermore, Mean lymphocyte count was significantly low in dengue patients compared to non-dengue patients (Student’s (t) test=-5.1; p<.001). Other haematological parameters were not significantly different. Lymphopenia was a significant predictor for dengue positive results (Adjusted Odd Ration =5.26 (95% CI=2.28-12.2; P value <.001). Conclusion: Patients with dengue had significantly low total white blood cell and lymphocyte count compared to non-dengue febrile patients. Lymphopenia is a significant haematological predictor for dengue positive results. Case defining signs and symptoms combined with these haematological changes may be used by clinicians as a guide to order confirmatory test for suspected dengue cases.

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“…Regression models were adjusted for child birthweight, child sex, breastfeeding duration maternal education, and total monthly income, each of which were previously found to be associated with both early complementary feeding and child BMI. 16,[21][22][23][24]…”

Section: Discussionmentioning

confidence: 99%

Early Feeding Practices and Body Mass Index Z-Score among Saudi Preschoolers: A Cross-Sectional Study

Mosli¹

2021

Preprint

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ObjectivesTo characterize early feeding practices among mothers in Saudi Arabia and examine their associations with child birthweight and BMI z-score (BMIz) at preschool. Study DesignCross-sectional study. MethodsMother-child dyads (n=209) were recruited from different preschools around the city of Jeddah. Mothers completed the study questionnaire over the telephone and preschoolers’ anthropometric measurements were objectively measured. Descriptive statistics were used to characterize early feeding practices. Bivariate analyses and linear regression were used to examine the association of early feeding practices with child birthweight and BMIz at preschool. ResultsThe majority of mothers (92.3%) initiated breastfeeding, with an average duration of 9.34 months (SD= 8.04). About half of the mothers reported that they have offered fruit juice and/or date syrup-milk mixture in a baby bottle (52.2% and 45.9% respectively), with an average duration of 11.5 months (SD= 7.73) and 5.90 months (SD= 6.13), respectively. Children who were offered fruit juice and/or date syrup-milk mixture in a baby bottle had significantly lower birthweights compared to children who were not (M= 2.79, SD= 0.59 vs. M= 3.06, SD=0.69, P< 0.01 and M= 2.79, SD= 0.67 vs. M= 3.03, SD=0.62, P< 0.01, respectively). There was a negative association between introducing fruit juice in a baby bottle and child BMIz at preschool (b: 0.18, 95% confidence interval (CI): -0.83, -0.11); This association was not significant after adjusting for child birthweight and other covariates (b: -0.10, 95% CI: -0.64, 0.09). ConclusionLongitudinal and interventions studies are needed to inform counseling guidelines and community campaigns in order to improve early feeding practices in the region.

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Predictors of Exclusive Breastfeeding for 6 Months in a National Sample of US Children

Abstract: Rates of exclusive breastfeeding for 6 months remain low in the United States. Single-parent and step-families, lower income families, non-Hispanic black children, children with exposure to tobacco, and children of mothers with lower education are at greatest risk.

Cited by 45 publications

References 37 publications

The Profile of Human Milk Metabolome, Cytokines, and Antibodies in Inflammatory Bowel Diseases Versus Healthy Mothers, and Potential Impact on the Newborn

The Profile of Human Milk Metabolome, Cytokines, and Antibodies in Inflammatory Bowel Diseases Versus Healthy Mothers, and Potential Impact on the Newborn

Use of Haematological Changes as a Predictor of Dengue Infection among Suspected Cases at Kairuki Hospital in Dar Es Salaam, Tanzania: A Retrospective Cross Sectional Study

Early Feeding Practices and Body Mass Index Z-Score among Saudi Preschoolers: A Cross-Sectional Study

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