Predictors of drug-drug interactions of medications prescribed to patients admitted due to suicidal behavior

Vanzela, Amanda Sarah; Silva, Aline Conceição; Borges, Tatiana Longo; Castilho, Ellen Carolina Dias; Miasso, Adriana Inocenti; Zanetti, Ana Carolina Guidorizzi; Alonso, Jonas Bodini; Vedana, Kelly Graziani Giacchero

doi:10.1016/j.heliyon.2022.e08850

Cited by 2 publications

(1 citation statement)

References 42 publications

(66 reference statements)

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“…The medical doctors who share this kind of treatment responsibility may have extensive workloads—which may contribute to the chance of errors occurring. Errors might be prevented by improving routines for interprofessional collaboration in units, by reducing the workload of the medical doctors, thus allowing more time for follow-up, by improving psychopharmacology training of doctors in training, and by increasing prescribing supervision at the unit—for instance, by involving expert pharmacists in the day-to-day treatment of patients [ 37 , 38 ]. Errors relating to the psychotherapeutic treatment itself could be due to factors such as inadequate initial assessment of the patient or inadequate assessment of changes in the patient’s condition, inadequate psychotherapeutic training or lack of supervision of junior staff, the use of psychotherapeutic approaches that do not meet the patient’s needs, lack of time or continuity in treatment, etc.…”

Section: Discussionmentioning

confidence: 99%

Patients Who Die by Suicide: A Study of Treatment Patterns and Patient Safety Incidents in Norway

Krvavac

Jansson

Bukholm

et al. 2022

IJERPH

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Underlying patterns and factors behind suicides of patients in treatment are still unclear and there is a pressing need for more studies to address this knowledge gap. We analysed 278 cases of suicide reported to The Norwegian System of Patient Injury Compensation, drawing on anonymised data, i.e., age group, gender, diagnostic category, type of treatment provided, inpatient vs. outpatient status, type of treatment facility, and expert assessments of medical errors. The data originated from compensation claim forms, expert assessments, and medical records. Chi-square tests for independence, multinominal logistic regression, and Bayes factors for independence were used to analyse whether the age group, gender, diagnostic category, inpatient/outpatient status, type of institution, and type of treatment received by patients that had died by suicide were associated with different types of medical errors. Patients who received medication tended to be proportionally more exposed to an insufficient level of observation. Those who received medication and psychotherapy tended to be proportionally more exposed to inadequate treatment, including inadequate medication. Inpatients were more likely to be exposed to inappropriate diagnostics and inadequate treatment and follow up while outpatients to insufficient level of observation and inadequate suicide risk assessment. We conclude that the patients who had received medication as their main treatment tended to have been insufficiently observed, while patients who had received psychotherapy and medication tended to have been provided insufficient treatment, including inadequate medication. These observations may be used as learning points for the suicide prevention of patients in treatment in Norwegian psychiatric services.

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Section: Discussionmentioning

confidence: 99%

Patients Who Die by Suicide: A Study of Treatment Patterns and Patient Safety Incidents in Norway

Krvavac

Jansson

Bukholm

et al. 2022

IJERPH

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Prevalence of polypharmacy and factors impacting psychotropic prescribing patterns in women of childbearing potential at inpatient mental health services in Qatar

Elbakary,

Abdallah,

Ouanes

et al. 2024

Neuropsychopharm Rep

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AimsWomen may experience unique mental disorders due to hormone shifts. Rates of schizophrenia and bipolar disorder are similar between genders, but onset and symptoms may differ. Women tend to use more psychotropic drugs due to limited therapeutic options. This study was aimed to estimate the prevalence of psychotropic polypharmacy among females of childbearing potential and factors impacting prescribing patterns.MethodsThis was a quantitative retrospective chart review for patients admitted to inpatient units at the Mental Health Hospital in Qatar. SPSS® Statistics was used for data analysis. In addition to descriptive statistics applied, linear regression and binary logistic regression models were used to examine the clinical and sociodemographic factors associated with polypharmacy and full therapeutic response upon discharge, respectively. An alpha value of 0.05 was used.ResultsOf the 347 patients, 52.7% of the patients received a prescription of at least two psychotropic drugs upon discharge. Around two‐thirds (63.1%) were prescribed at least one antipsychotic. Potential predictors of polypharmacy were age (p = 0.027), longer hospital stay (p = 0.003), family history (p < 0.001), absence of suicidal history (p = 0.005), and a diagnosis of a mood disorder (p = 0.009), or a diagnosis of a psychotic disorder (p = 0.015). A full response upon discharge was less likely to occur in patients with a longer stay (OR = 0.940; p = 0.029) and in those with a substance use disorder (OR = 0.166; p = 0.035).ConclusionThere is a notably high prevalence of total polypharmacy upon discharge. Some identified factors are modifiable. Evidence‐based prescription practices through hospital guidelines and education should be emphasized to avoid unreasonable polypharmacy.

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Predictors of drug-drug interactions of medications prescribed to patients admitted due to suicidal behavior

Cited by 2 publications

References 42 publications

Patients Who Die by Suicide: A Study of Treatment Patterns and Patient Safety Incidents in Norway

Patients Who Die by Suicide: A Study of Treatment Patterns and Patient Safety Incidents in Norway

Prevalence of polypharmacy and factors impacting psychotropic prescribing patterns in women of childbearing potential at inpatient mental health services in Qatar

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