Predictors of dementia in Parkinson disease

Anang, Julius; Gagnon, Jean‐François; Bertrand, Jean‐Marie; Romenets, Silvia Ríos; Latreille, Véronique; Panisset, Michel; Montplaisir, Jacques; Postuma, Ronald B.

doi:10.1212/wnl.0000000000000842

Cited by 345 publications

(298 citation statements)

References 42 publications

(41 reference statements)

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“…Since PD patients with RBD are likely to develop dementia and hallucinations (Anang, et al, 2014,Sinforiani, et al, 2008, eventually presenting a phenotype similar to DLB, and based on the current and previous genetic and post-mortem results , we hypothesize that RBD-associated synucleinopathy (the central common area in Figure 1) is the same clinicalpathological entity, whether it is defined as parkinsonism first with subsequent dementia and hallucinations, or whether it is defined as DLB with subsequent parkinsonism. In that sense, RBD can be considered as a marker for diffuse synucleinopathy, which may be a better description of the disease than DLB or PD with dementia.…”

Section: Discussionmentioning

confidence: 92%

“…With long term follow-up, more than 80% of individuals with idiopathic RBD developed either Parkinson's disease (PD), dementia with Lewy bodies (DLB) or multiple system atrophy (MSA) ,Schenck, et al, 2013. It was suggested that RBD may define a subtype of PD patients (Fereshtehnejad, et al, 2015,Gagnon, et al, 2004 with cognitive decline (Gagnon, et al, 2009,Vendette, et al, 2007, dementia (Anang, et al, 2014), hallucinations (Sixel-Doring, et al, 2011) and autonomic dysfunction (Postuma, et al, 2008), as compared to PD patients without RBD. In addition, pathological studies in brains of PD patients with and without RBD demonstrated a more widespread -synuclein accumulation in those associated with RBD .…”

Section: Introductionmentioning

confidence: 99%

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The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Gan‐Or

Montplaisir

Ross

et al. 2017

Neurobiology of Aging

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The dementia-associated APOE ε4 allele is not associated with REM sleep behavior disorder, Neurobiology of Aging (2016Aging ( ), doi: 10.1016Aging ( /j.neurobiolaging.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTAbstract: The current study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic REM sleep behavior disorder (RBD). Two SNPs, rs429358 and rs7412, were genotyped in RBD patients (n=480) and in controls (n=823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR=1.11, 95% CI 0.88-1.40, p=0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to PD (0.12) or multiple system atrophy (0.14, p=1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Gan‐Or

Montplaisir

Ross

et al. 2017

Neurobiology of Aging

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“…The pattern of cognitive deficits in PDD and DLB, however, appears to differ in significant ways from that of AD [4-7, 9, 10, 23]. Furthermore, evidence suggests that there are specific relationships between motor and gait impairment patterns and the type of cognitive impairment or dementia condition present [1,2,[24][25][26][27][28][29][30].…”

Section: Dw Scharre Et Al / Comparing Lbd With Ad and Pdmentioning

confidence: 99%

“…Research on the diagnosis and management of dementia with Lewy bodies (DLB) has increased greatly in the past decade [1][2][3][4][5][6][7][8][9][10][11]. Currently it is thought that DLB represents about 10-15% of all dementia cases [12].…”

Section: Introductionmentioning

confidence: 99%

Paired Studies Comparing Clinical Profiles of Lewy Body Dementia with Alzheimer’s and Parkinson’s Diseases

Scharre

Chang

Nagaraja

et al. 2016

JAD

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Abstract. Limited data compares clinical profiles of Lewy Body Dementia (LBD) with Alzheimer's disease (AD) andParkinson's disease (PD). Twenty-one mildly demented ambulatory LBD subjects were individually matched by MMSE score with 21 AD subjects and by UPDRS motor score with 21 PD subjects. Matched by age, gender, education, and race, pairs were compared using cognitive, functional, behavioral, and motor measures. LBD group performed worse than PD on axial motor, gait, and balance measures. AD had more amnesia and orientation impairments, but less executive and visuospatial deficits than LBD subjects. LBD group had more sleepiness, cognitive/behavioral fluctuations, hallucinations, and sleep apnea than AD or PD. Axial motor, gait, and balance disturbances correlated with executive, visuospatial, and global cognition deficits. LBD is differentiated from AD and PD by retrieval memory, visuospatial, and executive deficits; axial motor, gait and balance impairments; sleepiness, cognitive/behavioral fluctuations, hallucinations, and sleep apnea.

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“…Demographic features such as the subject's age, age at onset of motor symptoms, and disease duration are significant predictors of cognitive impairment in PD [18] [19] [20]. Several NMS, including neuropsychiatric (depression, hallucinations) and sleep disorders (REM sleep behavior disorder, RBD) [21] and cardiovascular autonomic failure [22] are positively associated with the development of dementia in PD. As to the motor features, cognitive deficit is significantly more frequent and severe in akinetic-rigid in comparison to tremor-predominant cases of PD [23].…”

Section: Cognitive Impairment In Pdmentioning

confidence: 99%

Levodopa/Carbidopa Intestinal Gel for Treatment of Advanced Parkinson’s Disease: An Update on the Effects of Cognitive Functions

Latino¹,

Tagliente²,

Pellicano³

et al. 2017

APD

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Cognitive impairment is a frequent non-motorsymptom of Parkinson's disease (PD). In early disease stage, this takes the features of dysexecutive syndrome, and is mostly dependent on derangement of frontostriatal circuitries. In advanced stages, worsening of dysexecutive symptoms is accompanied by disorientation and memory deficit leading to dementia in 30% of cases, due to multiple neurotransmitter derangement. Dysexecutive symptoms in the early stages of PD may benefit from dopamine replacement therapy (DRT). Conversely, severe cognitive symptoms in more advanced stages are frequently aggravated by DRT. In particular, pulsatile stimulation of dopaminergic receptors by orally administered levodopa (LD) plays a significant negative role on cognitive and neuropsychiatric symptoms in advanced PD. The introduction of a gel of LD-carbidopa for continuous intestinal administration (LCIG) allows marked stabilization of plasma LD concentrations and provides benefit on motor fluctuations and dyskinesia of significantly greater magnitude than conventional oral administration in advanced PD patients. The results from several preliminary studies suggest that efficacy of LCGI on motor symptoms may be accompanied by good tolerability and potential benefit on several non-motor symptoms, including cognitive impairment. Future studies with longer observation period and larger cohorts are advised to confirm these preliminary observations.

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Predictors of dementia in Parkinson disease

Abstract: Cardiovascular autonomic dysfunction, REM sleep behavior disorder, color discrimination ability, and gait dysfunction strongly predict development of dementia in Parkinson disease.

Cited by 345 publications

References 42 publications

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Paired Studies Comparing Clinical Profiles of Lewy Body Dementia with Alzheimer’s and Parkinson’s Diseases

Levodopa/Carbidopa Intestinal Gel for Treatment of Advanced Parkinson’s Disease: An Update on the Effects of Cognitive Functions

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