Predictors of Coronary Artery Disease in Patients with Behçet's Disease

Garg, Jalaj; Krishnamoorthy, Parasuram; Palaniswamy, Chandrasekar; Doshi, Jay; Lanier, Gregg M.; Ahmad, Hasan

doi:10.1159/000365139

Cited by 24 publications

(10 citation statements)

References 11 publications

(15 reference statements)

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“…Also, in similar inflammatory disease as RA and SLE, chronic inflammatory disease strongly contributes to coronary microvascular dysfunction [21]. As shown in our patient, this early occurrence of atherosclerosis causes significant morbidity, corresponding with the observations that traditional risk factors are an independent predictor of CAD-related morbidity in young BD patients [14]. Therefore, we believe optimal risk stratification is necessary to prevent morbidity in BD patients.…”

Section: Case Reportsupporting

confidence: 81%

“…However, so far only this report of a subgroup of BD patients and 4 cases with non-BD-related cardiovascular disease have been reported [15][16][17]. Prevalence of risk factors associated with coronary artery disease are similar as compared to the overall population, however the high incidence of cardiovascular disease at a relatively young age in these BD patients suggest that atherosclerosis might be accelerated in BD patients [14]. In addition to this, in BD patients without risk factors, subclinical atherosclerosis is found [18].…”

Section: Case Reportmentioning

confidence: 79%

“…Recently, a prevalence of 12% for coronary artery disease (CAD) in BD patients was reported in a large cohort in the USA. This retrospective study, in which only hospitalized BD patients were included, urged to screen BD patients for CAD risk factors, to prevent cardiovascular disease [14]. However, so far only this report of a subgroup of BD patients and 4 cases with non-BD-related cardiovascular disease have been reported [15][16][17].…”

Section: Case Reportmentioning

confidence: 99%

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Patients with Behcet’s Disease and Cardiovascular Risk Factors are at Risk for Early Cardiovascular and Renal Disease

Hcvd¹,

Tbvd²,

Jh³

et al. 2017

J Clin Case Rep

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We present a case of a 39-year-old Turkish female patient with a mild clinical phenotype of Behçet's disease (BD), but experiencing severe cardiac and renal disease, probably enhanced by microvascular atherosclerosis and hypertension. In this case, several cardiovascular risk factors like positive family history, hypertension and smoking were present. Up until recently cardiovascular risk factors were relatively neglected in BD, however recent reports suggest that traditional risk factors are an independent predictor of early coronary artery disease-related morbidity in young BD patients. With this case report we want to stress the fact that severe atherosclerotic complications occur even in young BD patients with longstanding stable, mild disease. This is probably due to chronic inflammation process in chronic diseases like BD, which is a known factor in the initiation and progression of the atherosclerotic process. Therefore, a tight, careful risk factor management should be implied during the follow-up of BD patients.

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Section: Case Reportsupporting

confidence: 81%

Section: Case Reportmentioning

confidence: 79%

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Patients with Behcet’s Disease and Cardiovascular Risk Factors are at Risk for Early Cardiovascular and Renal Disease

Hcvd¹,

Tbvd²,

Jh³

et al. 2017

J Clin Case Rep

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“…However, there is an obvious gap in the literature reporting body composition in BD. In contrast to RA and SLE, the knowledge about body composition and the levels of ghrelin and obestatin in BD is limited (20,21).…”

Section: Introductionmentioning

confidence: 99%

Low prevalence of obesity in Behçet’s disease is associated with high obestatin level

Koca¹,

Kara²,

Özgen³

et al. 2017

Eur J Rheumatol

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Objective: Chronic inflammatory diseases are associated with altered body composition. Ghrelin has anti-inflammatory effects, and its level is altered in obesity and inflammatory diseases. The aim of the study was to evaluate the prevalence of obesity and ghrelin and obestatin levels in patients with Behçet's disease (BD). Material and Methods:One hundred and forty-three (143) ). In addition to the routine evaluations (fasting blood glucose, lipid profile, and kidney and liver function tests), serum acylated-ghrelin (AG), unacylated-ghrelin (UAG), total ghrelin (TG) and obestatin levels were analyzed. Student's t-test and chi-square test were used for statistical analysis.Results: The prevalence of obesity was relatively lower in the BD group than in the HC group (12.6% vs. 20.5%, p=0.089). Serum ghrelin levels were similar in the BD and HC groups (p>0.05 for all) although the obestatin level was higher in the BD group compared to the HC group (p<0.001). Serum UAG, TG and obestatin levels were lower in obese BD patients (n=18) than non-obese BD patients (p=0.027, p=0.014 and p=0.001, respectively). Conclusion:The obestatin level was high and the prevalence of obesity was low in the BD group. Moreover, obese BD patients had low obestatin levels. These results suggest that obestatin may protect BD patients from obesity.

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“…Pandey et al [9] have assessed the prevalence and predictors of coronary artery disease (CAD) in patients with Behçet's disease. Although traditional risk factors related to CAD were similar to what is expected in the overall population, young Behçet's disease patients with CAD have a significantly accelerated course of atherosclerosis [9].…”

Section: Vascular Involvementmentioning

confidence: 99%