Background:The degree of patient's suffering in association with radiological evidence of osteoarthritis (OA) determines the time point of surgery. Thus, a more clear understanding of the association between clinical and radiological symptoms of OA is necessary. Objectives: Here we aim to evaluate how clinical and radiographic symptoms of patients are associated with each other in an Iranian Knee OA population. Methods: In a cross -sectional study, patients with knee OA were recruited. The diagnosis of OA was made using the criteria of American College of Rheumatology (ACR) Classification. Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) was used as an indicator of self-reported disability. The Kellgren -Lawrence index was used for OA grading.Results: A total of 96 OA patients, including 77 females and 19 males, with a mean age of 53.27 ± 10 years, were included. The OA was graded as I, II, III, and IV in 28, 35, 19, and 14 patients, respectively. The mean WOMAC score was 55.2 ± 20.5, ranging from 6.3 to 100.The WOMAC score was not significantly correlated with the grade of OA (p = 0.1, r = -0.188). When we stratified the patients based on their gender, a strong correlation was observed between WOMAC scores and OA grade in male patients (p < 0.001, r = -0.882), while it was still non -significant in female patients (p = 0.9, r = 0.002). Conclusions: Self -reported disability is associated with radiographic symptoms in male patients with knee OA, but not in females.Hence, the orthopedic surgeons should consider this discrepancy in their decision -making process to decide appropriately about the choice of therapy.Given the role of clinical symptoms in the appropriate selection of OA patients as TKA candidates, a more clear understanding of the association between clinical and radiological symptoms is necessary.