Predictors of colorectal carcinoma and inflammatory bowel disease in patients with colonic wall thickening

Pothoulakis, Ioannis; Wikholm, Colin; Verma, Vipin; Ahmad, Akram; Vangimalla, Shiva Shankar; Patel, Harshkumar; Oh, Jae Hak; Na, Xiaona; Gress, Kyle; Bovill, John D.; Deshpande, Nikita; Márquez, María Silvina; Dean, Brynley; Gholson, Dwight A; Bhogal, Loveleen; Buchanan, Faith; Cho, Won Kyoo

doi:10.1002/jgh3.12708

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Nevertheless, there are instances where the primary lesion remains elusive despite extensive diagnostic scrutiny, particularly in the context of hollow organ tumours [ 11 , 12 , 13 ]. Gastrointestinal wall thickness, assessable via computed tomography (CT) scans, can increase due to benign factors, such as inflammation, ulcers, polyps, tuberculosis, Crohn’s disease, diverticula, or Menetrier’s disease [ 14 ]. In addition, 18F-FDG positron emission tomography (PET)/CT exhibits limited diagnostic utility in detecting primary hollow organ tumours [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Radiomics Nomogram for Liver Metastases Originating from Gastric and Colorectal Cancer

Li,

Meng

et al. 2023

Diagnostics

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The origin of metastatic liver tumours (arising from gastric or colorectal sources) is closely linked to treatment choices and survival prospects. However, in some instances, the primary lesion remains elusive even after an exhaustive diagnostic investigation. Consequently, we have devised and validated a radiomics nomogram for ascertaining the primary origin of liver metastases stemming from gastric cancer (GCLMs) and colorectal cancer (CCLMs). This retrospective study encompassed patients diagnosed with either GCLMs or CCLMs, comprising a total of 277 GCLM cases and 278 CCLM cases. Radiomic characteristics were derived from venous phase computed tomography (CT) scans, and a radiomics signature (RS) was computed. Multivariable regression analysis demonstrated that gender (OR = 3.457; 95% CI: 2.102–5.684; p < 0.001), haemoglobin levels (OR = 0.976; 95% CI: 0.967–0.986; p < 0.001), carcinoembryonic antigen (CEA) levels (OR = 0.500; 95% CI: 0.307–0.814; p = 0.005), and RS (OR = 2.147; 95% CI: 1.127–4.091; p = 0.020) exhibited independent associations with GCLMs as compared to CCLMs. The nomogram, combining RS with clinical variables, demonstrated strong discriminatory power in both the training (AUC = 0.71) and validation (AUC = 0.78) cohorts. The calibration curve, decision curve analysis, and clinical impact curves revealed the clinical utility of this nomogram and substantiated its enhanced diagnostic performance.

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Section: Introductionmentioning

confidence: 99%

Development and Validation of a Radiomics Nomogram for Liver Metastases Originating from Gastric and Colorectal Cancer

Li,

Meng

et al. 2023

Diagnostics

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Association Between Bowel Wall Thickening and Long-Term Outcomes in Decompensated Liver Cirrhosis

Wang,

Ding,

Wang

et al. 2023

Adv Ther

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Combined SUVmax and localized colonic wall thickening parameters to identify high-risk lesions from incidental focal colorectal 18F-FDG uptake foci

Li²,

Guo³

et al. 2022

Front. Oncol.

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ObjectiveTo evaluate the detection ability of 18F-FDG PET/CT for identifying high-risk lesions (high-risk adenomas and adenocarcinoma) from incidental focal colorectal 18F-FDG uptake foci combining maximum standard uptake value (SUVmax) and localized colonic wall thickening (CWT). The secondary objective was to investigate the factors of missed detection of high-risk adenomas by 18F-FDG PET/CT.Patients and methodsA total of 6394 patients who underwent 18F-FDG PET/CT in our hospital from August 2019 to December 2021 were retrospectively analysed, and 145 patients with incidental focal colorectal 18F-FDG uptake foci were identified. The optimal cut-off value of SUVmax for 18F-FDG PET/CT diagnosis of high-risk lesions was determined by receiver operating characteristic (ROC) curves. SUVmax and localized CWT were combined to identify high-risk lesions from incidental focal colorectal 18F-FDG uptake foci. The characteristics of incidental adenomas detected and high-risk adenomas missed by 18F-FDG PET/CT were compared.ResultsOf the 6394 patients, 145 patients were found to have incidental focal colorectal FDG uptake foci (2.3%), and 44 patients underwent colonoscopy and pathological examination at the same time. In fact, 45 lesions, including 12 low-risk lesions and 33 high-risk lesions (22 high-risk adenomas, 11 adenocarcinoma), were found by colonoscopy. The area under the ROC curve of SUVmax for low-risk lesions and high-risk lesions was 0.737, and the optimal cut-off value was 6.45 (with a sensitivity of 87.9% and specificity of 58.3%). When SUVmax ≥6.45, the combination of localized CWT parameters has little influence on the sensitivity and specificity of detection; when SUVmax <6.45, the combination of localized CWT parameters can improve the specificity of detection of high-risk lesions, but the sensitivity has little change. In addition, the size of high-risk adenomas discovered incidentally by 18F-FDG PET/CT was larger than that of high-risk adenomas missed, but there was no significant difference in lesion location, pathological type or intraepithelial neoplasia between the two groups.ConclusionsThe combination of SUVmax and localized CWT parameters of 18F-FDG PET/CT helped identify high-risk lesions from incidental focal colorectal 18F-FDG uptake foci, especially for lesions with SUVmax <6.45. Lesion size may be the only factor in 18F-FDG PET/CT missing high-risk adenomas.

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Predictors of colorectal carcinoma and inflammatory bowel disease in patients with colonic wall thickening

Cited by 3 publications

References 38 publications

Development and Validation of a Radiomics Nomogram for Liver Metastases Originating from Gastric and Colorectal Cancer

Development and Validation of a Radiomics Nomogram for Liver Metastases Originating from Gastric and Colorectal Cancer

Association Between Bowel Wall Thickening and Long-Term Outcomes in Decompensated Liver Cirrhosis

Combined SUVmax and localized colonic wall thickening parameters to identify high-risk lesions from incidental focal colorectal 18F-FDG uptake foci

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