Predictors of chlordiazepoxide response in anxiety

Rickels, Karl; Downing, Robert W.; Howard, Kay

doi:10.1002/cpt1971122part1263

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…The present findings are supported by results from several earlier studies ( 1,4,5). The finding that chlordiazepoxide produced more clinical improvement than hydroxyzine (p <0.10) agrees with our previous study of the 2 drugs and placebo (1), in which several global endpoint measures of improvement indicated better response to chlordiazepoxide than to hydroxyzine.…”

Section: Discussionsupporting

confidence: 82%

Prognostic Indicators of 4-Week Clinical Improvement with Chlordiazepoxide and Hydroxyzine in Anxious Neurotic Outpatients

Rickels¹,

Csanalosi²,

Rw³

et al. 1971

Int Pharmacopsychiatry

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A multiple regression analysis conducted with 125 anxious outpatients has indicated chlordiazepoxide (40 mg/day) to produce more improvement than hydroxyzine (400 mg/day); and patients from general practice, with better prognoses, and with higher initial anxiety to do better, irrespective of treatment agent, than patients from clinics, with poor prognoses, and with low initial anxiety. Furthermore, the analysis indicated chlordiazepoxide to produce more improvement than hydroxyzine in more chronically ill, more liked, and employed patients, while hydroxyzine was especially effective in less liked and unemployed patients. Several explanations have been offered for these findings.

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Section: Discussionsupporting

confidence: 82%