Predictors of change in estimated GFR: a population-based 7-year follow-up from the Tromso study

Kronborg, Jens; Solbu, Marit Dahl; Njølstad, Inger; Toft, Ingrid; Eriksen, Bjørn Odvar; Jenssen, Trond

doi:10.1093/ndt/gfn148

Cited by 81 publications

(97 citation statements)

References 41 publications

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“…White et al 33 demonstrated that, in Australian adults, self-categorization as a moderate or heavy drinker or an average consumption of 30 g of ethanol per day or more was associated with significantly elevated risks of developing albuminuria over 5 years of follow-up, compared with light alcohol consumption. Kronborg et al 34 reported that, among males, consumption of seven or more units of alcohol per week was associated with a significant increase in estimated glomerular filtration rate (eGFR) over 7 years of follow-up. Assadi et al 35 reported that ethanol treatment rats showed cytoplasmic mitochondrial atrophy and vacuolar structures of the epithelial cells of the distal tubules and collecting ducts.…”

Section: Discussionmentioning

confidence: 99%

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

et al. 2012

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Objectives: The aim of this study was to investigate the preventive effects of melatonin and vitamin C as antioxidants on renal injury in chronic alcohol consumption. Materials and methods: A total of 24 adult male Wistar rats weighing 200-250 g were used in the study. Rats were divided into four equal groups. Group I (control): rats were not fed on alcohol; Group II: rats were fed on alcohol; Group III: rats were fed on alcohol and 40 mg/kg vitamin C; and Group IV: rats were fed on alcohol and 4 mg/kg melatonin. Results: Light microscopic examination revealed atrophic renal corpuscles, dilatation and congestion of the peritubular vessels, and renal corpuscles with obscure Bowman's space and a few foamy-appearing tubules due to alcohol consumption were observed. Expression of endothelial nitric oxide synthase (eNOS) was localized to glomerulus, distal, and collector tubules. eNOS staining decreased in alcohol treatment group and melatonin and vitamin C encore increased expression pattern of eNOS. Alcohol consumption increased malondialdehyde (MDA) level and superoxide dismutase (SOD) and catalase (CAT) activities significantly in the alcohol consumption groups compared with that in the control group, while in melatonin give group just MDA level was decreased statistically significant and SOD and CAT activities were also decreased numerically compared with the alcohol consumption groups. Conclusions: These results indicated that chronic alcohol consumption caused renal damage by increased lipid peroxidation and melatonin and vitamin C administration produced in some degree protection against alcohol-induced damage.

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Section: Discussionmentioning

confidence: 99%

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

et al. 2012

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“…10 Creatinine was measured as previously described. 11 We calculated the estimated glomerular filtration rate (eGFR) according to the CKD-EPI formula. 12 Descriptions of measurements of lipids and HbA1c have been published previously.…”

Section: Measurementsmentioning

confidence: 99%

Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994–2013

et al. 2017

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Aims To investigate whether serum uric acid predicts adverse outcomes in persons with indices of diastolic dysfunction in a general population. Methods and resultsWe performed a prospective cohort study among 1460 women and 1480 men from 1994 to 2013. Endpoints were all-cause mortality, incident myocardial infarction, and incident ischaemic stroke. We stratified the analyses by echocardiographic markers of diastolic dysfunction, and uric acid was the independent variable of interest. Hazard ratios (HR) were estimated per 59 μmol/L increase in baseline uric acid. Multivariable adjusted Cox proportional hazards models showed that uric acid predicted all-cause mortality in subjects with E/A ratio <0.75 (HR 1.12, 95% confidence interval [CI] 1.00-1.25) or E/A ratio >1.5 (HR 1.51, 95% CI 1.09-2.09, P for interaction between E/A ratio category and uric acid = 0.02). Elevated uric acid increased mortality risk in persons with E-wave deceleration time <140 ms or >220 ms (HR 1.46, 95% CI 1.01-2.12 and HR 1.13, 95% CI 1.02-1.26, respectively; P for interaction = 0.04). Furthermore, in participants with isovolumetric relaxation time ≤60 ms, mortality risk was higher with increasing uric acid (HR 4.98, 95% CI 2.02-12.26, P for interaction = 0.004). Finally, elevated uric acid predicted ischaemic stroke in subjects with severely enlarged left atria (HR 1.62, 95% CI 1.03-2.53, P for interaction = 0.047). Conclusions Increased uric acid was associated with higher all-cause mortality risk in subjects with echocardiographic indices of diastolic dysfunction, and with higher ischaemic stroke risk in persons with severely enlarged left atria.

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“…eGFRcrea was calculated using the recalibrated four-variable Modification of Diet in Renal Disease (MDRD) study equation; eGFRcrea = 175 x (s-creatinine (mmol/l)/88.4) −1.154 x age −0.203 x (0.742 if female). 21 Chronic kidney disease was categorized based on the National Kidney Foundation guidelines 22 using eGFRcrea; eGFR ≥90 mL/min/1.73 m 2 for normal kidney function, eGFR between 60 and 89 mL/min/1.73 m 2 for mildly impaired kidney function, and eGFR between 15 and 59 mL/min/1.73 m 2 for stage 3/4 chronic kidney disease. Three samples of morning spot-urine, collected on consecutive days, were tested with a dipstick and analyzed immediately for albumin and creatinine, using commercial kits (ABX Diagnostics; Montpellier, France).…”

Section: Assessment Of Renal Functionmentioning

confidence: 99%

Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study

Brodin¹,

Brækkan²,

Vik³

et al. 2012

Haematologica

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BackgroundPrevious studies have shown an association between impaired kidney function, assessed by cystatin C-based estimated glomerular filtration rate, and venous thromboembolism. The aim of this study was to investigate whether serum cystatin C was associated with a risk of venous thromboembolism among subjects with normal kidney function in a prospective population-based study. Design and MethodsCystatin C was measured in serum from 3251 men and women with normal kidney function, aged 25-84 years, who participated in the Tromsø study in 1994-1995. Normal kidney function was defined as a creatinine-based estimated glomerular filtration rate greater than 90 mL/min/1.73 m 2 and absence of microalbuminuria. Incident venous thromboembolism was registered from the date of inclusion through to the end of follow-up, September 1, 2007. Cox-regression models were used to calculate hazard ratios with 95% confidence intervals for venous thromboembolism. ResultsThere were 83 incident venous thromboembolic events, of which 53 (63.9 %) were provoked, during a median of 12.3 years of follow-up. A one standard deviation (0.11 mg/L) increase in serum cystatin C levels was associated with a 43% (hazard ratio 1.43; 95% confidence interval 1.17-1.72) increased risk of total venous thromboembolism. Subjects with cystatin C levels in the top quartile (≥0.87 mg/L) had a 2.5-fold (hazard ratio 2.51; 95% confidence interval 1.27-4.96) increased risk of venous thromboembolism compared to those with levels in the bottom quartile (≤0.72 mg/L) in adjusted analysis. The risk estimates were even higher for provoked venous thromboembolism (hazard ratio 3.11; 95% confidence interval 1.23-7.86). ConclusionsSerum cystatin C levels were associated with the risk of venous thromboembolism in subjects with normal kidney function. Our findings suggest that elevated serum cystatin C levels may promote venous thrombosis beyond reflecting impaired kidney function.Key words: cystatin C, venous thromboembolism, VTE, risk. 2012;97(7):1008-1013. doi:10.3324/haematol.2011 Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function -the Tromsø study Citation: Brodin EE, Braekkan SK, Vik A, Brox J, and Hansen J-B. Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function -the Tromsø study. Haematologica ABSTRACT© F e r r a t a S t o r t i F o u n d a t i o n

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Predictors of change in estimated GFR: a population-based 7-year follow-up from the Tromso study

Abstract: Some risk factors for change in GFR seem to be gender specific but both high SBP and high levels of fibrinogen contribute to a more rapid decline in GFR for both men and women.

Cited by 81 publications

References 41 publications

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994–2013

Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study

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