Predictors of Back Pain in Middle‐Aged Women: Data From the Australian Longitudinal Study of Women's Health

Brady, Sharmayne; Hussain, Sultana Monira; Brown, Wendy J.; Héritier, Stéphane; Wang, Yuanyuan; Teede, Helena; Urquhart, Donna M.; Cicuttini, Flavia Maria

doi:10.1002/acr.22982

Cited by 18 publications

(17 citation statements)

References 52 publications

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“…Seven studies27 29 30 34 41 47 49 defined the levels of physical activity based on frequency of weekly physical activity, five24 35 43 45 51 defined the levels based on number of hours per week, seven3 4 37 39 42 53 57 defined the levels based on number of hours and intensity of activity, four5 7 46 48 defined the levels based on frequency and duration of activity, one31 defined the levels based on frequency and intensity of activity and one56 defined the levels based on frequency, duration and intensity of activity. Moreover, participation in sport or other leisure time physical activities was based on a yes/no question in six studies,33 36 38 40 44 67 which only one36 considered duration and one44 considered intensity of activity.…”

Section: Resultsmentioning

confidence: 99%

Does leisure time physical activity protect against low back pain? Systematic review and meta-analysis of 36 prospective cohort studies

2017

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background There are plausible mechanisms whereby leisure time physical activity may protect against low back pain (LBP) but there have been no quality systematic reviews and meta-analyses of the subject. Objective This review aims to assess the effect of leisure time physical activity on non-specific LBP. Methods Literature searches were conducted in PubMed, Embase, Web of Science, Scopus and Google Scholar databases from their inception through July 2016. Methodological quality of included studies was evaluated. A random-effects meta-analysis was performed, and heterogeneity and publication bias were assessed. results Thirty-six prospective cohort studies (n=158 475 participants) qualified for meta-analyses. Participation in sport or other leisure physical activity reduced the risk of frequent or chronic LBP, but not LBP for >1 day in the past month or past 6-12 months. Risk of frequent/chronic LBP was 11% lower (adjusted risk ratio (RR)=0.89, CI 0.82 to 0.97, I 2 =31%, n=48 520) in moderately/highly active individuals, 14% lower (RR=0.86, CI 0.79 to 0.94, I 2 =0%, n=33 032) in moderately active individuals and 16% lower (RR=0.84, CI 0.75 to 0.93, I 2 =0%, n=33 032) in highly active individuals in comparison with individuals without regular physical activity. For LBP in the past 1-12 months, adjusted RR was 0.98 (CI 0.93 to 1.03, I 2 =50%, n=32 654) for moderate/high level of activity, 0.94 (CI 0.84 to 1.05, I 2 =3%, n=8549) for moderate level of activity and 1.06 (CI 0.89 to 1.25, I 2 =53%, n=8554) for high level of activity. conclusions Leisure time physical activity may reduce the risk of chronic LBP by 11%-16%. The finding, however, should be interpreted cautiously due to limitations of the original studies. If this effect size is proven in future research, the public health implications would be substantial.

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Section: Resultsmentioning

confidence: 99%

Does leisure time physical activity protect against low back pain? Systematic review and meta-analysis of 36 prospective cohort studies

2017

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“…Given that there are few effective treatments for back pain (Maher et al, 2017 ), primary prevention strategies aiming to reduce risk factors for back pain are critical. Obesity is a potential risk factor for the development of back pain (Brady et al, 2017 ); however, it is unclear whether this is due to physical loading on spinal structures or systemic factors. Previous studies have shown that back pain intensity and associated disability are related to increased fat mass, but not muscle mass (Urquhart et al, 2011 ), raising the possibility that there may be systemic factors at play.…”

Section: Introductionmentioning

confidence: 99%

Adipsin Concentrations Are Associated with Back Pain Independently of Adiposity in Overweight or Obese Adults

et al. 2018

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Objective: To compare cardiometabolic risk factors including cytokine and adipokine concentrations between individuals with and without back pain.Methods: In 62 overweight/obese adults (BMI ≥ 25 kg/m2; 23F/39M), we collected data on: self-reported back pain; anthropometry [BMI, waist circumference, body composition (dual energy X-ray absorptiometry—DEXA)]; metabolic parameters [fasting glucose; insulin sensitivity (hyperinsulinaemic-euglycaemic clamps)]; cardiovascular parameters (blood pressure, lipids); serum inflammation markers [high-sensitivity C-reactive protein (hsCRP; immunoturbidimetric-assay), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and IL-10 (multiplex-assay)]; and adipokines [leptin, adipsin, resistin, and adiponectin (multiplex-assay)].Results: Participants who reported having back pain in the past month (n = 24; 39%) had higher BMI (mean ± SD = 33.8 ± 6.3 vs. 30.2 ± 4.1 kg/m2, p = 0.008), fat-mass (39.9 ± 12.3 vs. 33.9 ± 9.8%, p = 0.04), and waist circumference (109.6 ± 16.8 vs. 101.0 ± 9.3 cm, p = 0.01) compared to those without back pain (n = 38; 61%). No differences were observed in cardiometabolic parameters, inflammatory markers, or adiponectin or resistin concentrations. Those reporting back pain had higher adipsin concentrations compared to those without back pain [median (IQR) = 744 (472–2,804) vs. 721 (515–867) ng/ml, p = 0.03], with a trend for higher leptin [5.5 (1.5–24.3) vs. 2.3 (1.5–6.7) ng/ml, p = 0.05], both of which persisted after adjustment for age and sex. Adipsin remained associated with back pain independently of adiposity (BMI, waist, fat-mass, or total %body fat; all p ≤ 0.03).Conclusions: Greater obesity, and higher adipsin and leptin concentrations were observed in those who reported back pain in the past month compared to those without back pain, and adipsin was associated with back pain independently of adiposity. Larger studies are needed to determine if adipsin could be a novel therapeutic target for prevention and/or treatment of back pain.

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“…Engaging in some forms of physical activity may increase the risk of low back pain (LBP), but in general a physically active lifestyle seems to be protective for LBP 1. The only known effective prevention method is exercise alone or exercise with education 2.…”

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confidence: 99%

Unlocking the potential of physical activity for back health

2017

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Predictors of Back Pain in Middle‐Aged Women: Data From the Australian Longitudinal Study of Women's Health

Cited by 18 publications

References 52 publications

Does leisure time physical activity protect against low back pain? Systematic review and meta-analysis of 36 prospective cohort studies

Does leisure time physical activity protect against low back pain? Systematic review and meta-analysis of 36 prospective cohort studies

Adipsin Concentrations Are Associated with Back Pain Independently of Adiposity in Overweight or Obese Adults

Unlocking the potential of physical activity for back health

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