Predictors of Arterial Blood Pressure Control During Deliberate Hypotension With Sodium Nitroprusside in Children

Abstract

Background-Sodium nitroprusside (SNP) is used to decrease arterial blood pressure (BP) during certain surgical procedures. There are limited data regarding efficacy of BP control with SNP. There are no data on patient and clinician factors that affect BP control. We evaluated the dose-response relationship of SNP in infants and children undergoing major surgery and performed a quantitative assessment of BP control.

Manniophyton fulvum extract attenuates sodium nitroprusside induced oxidative stress in wistar rats

“…The remaining four free CN are transported to the hepatocyte, react with thiosulfate and cobalamin to form thiocyanate and excreted by the kidneys. 3 Those not eliminated bind to both ferric (Fe 3+ ) and ferrous (Fe 2+ ) in tissue cytochrome oxidase inhibiting oxidative phosphorylation and concomitant production of ATP, the energy currency of cell. 23 Alternative energy production leads to abnormal production of lactic acid that may result to severe lactic acidosis.…”

“…In clinical and experimental conditions, toxicity of SNP has been reported to occur via the release of cyanide ions (CN -) and nitric monoxide (NO) and other reactive oxygen species (ROS). 3 to exhibit anti-oxidative functions and maintain redox homeostasis in mammals. 4 Covalent modifications of sulfhydryl groups by sulfane sulphur regulate many cellular processes.…”