Predictors of anxiety and depression 2 years following treatment in uveal melanoma survivors

Abstract

Survivors reporting symptoms, functional problems, and WREC should be monitored for anxiety and depression. Appropriate reassurance that symptoms do not signify future disease might help prevent anxiety.

Could worry and rumination mediate relationships between self‐compassion and psychological distress in breast cancer survivors?

“…In contrast with rumination, which focusses on current or past events (Hong, 2007), worry involves repeatedly thinking about future threats and is particularly associated with the development and maintenance of anxiety (Hong, 2007;Watkins, 2008). Worry is prospectively associated with anxiety and depression in cancer patients (Brown, Hope-Stone, Heimann, Damato, & Salmon, 2018).…”

Comparison between patient-reported outcomes after enucleation and proton beam radiotherapy for uveal melanomas: a 2-year cohort study

“…Unlike breast cancer, where women achieve reductions of fear and worry after mastectomy [27], enucleation did not differentially reduce worry compared to PBR. Enucleated patients were more likely to have monosomy 3, although evidence suggests that this is not necessarily associated with worry about recurrence [15]. Enucleation can reduce the small probability of local cancer recurrence, but we have no evidence that it reduces patients' subjective worry about recurrence.…”

“…Adverse patient-reported outcomes of PBR can include progressive visual impairments, linked to known central and peripheral visual loss and the presence of unwanted visual sensations, and cause discomfort owing to tissue damage to extraocular structures [9]. These outcomes are associated with the likelihood of developing longterm clinically relevant anxiety and depression in UM patients [15].…”

“…Studies in other cancers confirm that patients sometimes request radical surgeries to remove organs because they fear local cancer recurrence [16]. WREC is linked to clinically relevant anxiety [15], thus clinicians may regard reducing patients' fears of recurrence as a valid consideration for treatment choice [17]. However, there is as yet no evidence that enucleation reduces fear to a greater extent than PBR in UM patients.…”

Hydroiodination‐Triggered Cascade Reaction with I2/PPh3/H2O: Metal‐Free Access to 3‐Substituted Phthalides from 2‐Alkynylbenzoates

“…Phthalide (isobenzofuranone) is an important scaffold found in many biologically active and naturally occurring substances Therefore, numerous methods for the synthesis of phthalides have been reported in the last decade. Notably, the construction of the γ‐butyrolactone scaffold is a key step in the synthesis of phthalides, and numerous lactonization reactions have been reported, including the cyclization of 2‐(1‐hydroxyalkyl)benzaldehyde and its derivatives,[1b], the cyclization of o ‐aroylbenzoic acids, and other methods . To accomplish the efficient synthesis of phthalides, a number of transition‐metal‐catalyzed reactions were recently reported .…”