Predictors of abdominal aortic calcification progression in patients with chronic kidney disease without hemodialysis

Yamamoto, Daisuke; Suzuki, Susumu; Ishii, Hideki; Hirayama, Kenshi; Harada, Kazuhiro; Aoki, Toshijiro; Shibata, Yohei; Negishi, Yosuke; Tatami, Yosuke; Sumi, Takuya; Ichii, Takeo; Kawashima, Kayoko; Kunimura, Ayako; Kawamiya, Toshiki; Morimoto, Ryo; Yasuda, Yoshinari; Murohara, Toyoaki

doi:10.1016/j.atherosclerosis.2016.08.004

Cited by 17 publications

(20 citation statements)

References 35 publications

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“…The results that the patients who were with higher level of serum Gal‐3 were more easily to develop more severe AAC and progressed AAC provides clinical evidence regarding the role of Gal‐3 in uremic vascular calcification. Previous studies have also shown that aging, hypercalcemia, hyperphosphatemia, elevated iPTH, and low 25(OH)D 28 are prominent risk factors for AAC progression. In our cohort, we found that only age and iPTH were significantly associated with AAC progression among these factors.…”

Section: Discussionmentioning

confidence: 99%

The predictive value of serum galectin 3 for abdominal aortic calcification in maintenance hemodialysis patients: A prospective cohort study

Wang

Chen

et al. 2020

Hemodialysis International

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Introduction: Heterotopic vascular calcification is a common complication of maintenance hemodialysis (MHD) patients. Galectin 3 (Gal-3) has been reported to be associated with cardiovascular calcification. The current study aims to explore the potential predictive value of serum Gal-3 for severe abdominal aortic calcification (AAC) and AAC progression in MHD patients.Methods: A prospective cohort who underwent hemodialysis during July 2014 at the Blood Purification Center of Ruijin Hospital were followed up for 3 years. Two AAC assessments were performed: one at baseline and one after the 3-year follow-up period. Serum Gal-3 was detected with quantitative ELISA kits. SPSS 23.0 and MedCalc 11.4.2.0 were used to analyze the data.Findings: One hundred and fifty-two patients were recruited. Approximately 59.9% were male, the median age was 60 (50-67) years. Logistic regression analysis indicated that serum Gal-3 was an independent risk factor for both follow-up severe AAC and AAC progression. Receiver operating characteristic (ROC) curve analysis revealed significant prognostic value of serum Gal-3 for predicting severe AAC and AAC progression within 3 years. Discussion:We found serum Gal-3 is correlated to vascular calcification in ESRD patients. Gal-3 may be a potential biomarker of vascular calcification for MHD patients.

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Section: Discussionmentioning

confidence: 99%

The predictive value of serum galectin 3 for abdominal aortic calcification in maintenance hemodialysis patients: A prospective cohort study

Wang

Chen

et al. 2020

Hemodialysis International

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“…Our results, revealing a time course of aortic dilatation and calcification, support their conclusions. We previously reported that advanced chronic kidney disease (CKD) was associated with the rapid progression of AAC among CKD patients 20) . In this study, advanced renal dysfunction (eGFR 30 mL/ min/1.73 m 2 ) and DM predicted the rapid progression of aortic calcification in patients with CAD.…”

Section: Discussionmentioning

confidence: 99%

Impact of Diabetes Mellitus on the Aortic Wall Changes as Atherosclerosis Progresses: Aortic Dilatation and Calcification

Iwakawa

Tanaka

Ishii

et al. 2020

JAT

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An inverse association between diabetes mellitus (DM) and aortic dilatation has recently been reported. However, little is known about the association between DM and the progression of aortic dilatation/calcification as atherosclerosis progresses. Methods: We identified 216 patients who had undergone percutaneous coronary intervention (PCI) and abdominal computed tomography (CT) during the PCI and follow-up phases. The patients were classified into two groups: those with DM (DM+ group; n 107) and those without DM (DM− group; n 109). The infrarenal aortic diameter and aortic calcification index (ACI) were measured, and annual changes were calculated using measurement results obtained during the PCI and follow-up phases. Results: Infrarenal aortic diameters were significantly shorter in the DM+ group than in the DM-group during the PCI phase, and no significant ACI differences were observed between the DM+ and DM− groups. The median duration between the PCI and follow-up phase CT was 3.0 years. The growth rate of the infrarenal aortic dilatation from the PCI phase in the DM+ group was similar to that in the DM− group. Annual ACI changes were significantly larger in the DM+ group than in the DM− group. Multivariate logistic regression analysis indicated that the prevalence of DM was an independent predictor of rapid aortic calcification progression (odds ratio: 2.51; 95% confidence interval: 1.23-5.14; p 0.01). Conclusion: Our findings suggest that DM negatively affects aortic dilatation during an earlier phase of atherosclerosis progression and positively affects the progression of aortic calcification in a later phase. known about the time course. On the contrary, vascular calcification is considered an important process in atherosclerosis. A prior report showed that patients with DM had a greater incidence of and absolute progression in coronary artery calcification 10) , although the relationship between DM and aortic calcification has not been fully elucidated. The purpose of this study was to assess the impact of DM on the progression of aortic dilatation and calcification in patients with coronary artery disease (CAD).

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“…The cross-section of the abdominal aorta on each slice was radially divided into 12 segments. ACI was calculated as follows: ACI = (total calcification score on all slices)/12 × 1/(number of slices) × 100% 6 , 10 , 15 ) . ACI was independently calculated by two physicians who were blinded to the clinical and biochemical aspects of each study patient.…”

Section: Methodsmentioning

confidence: 99%

“…Vascular calcification (VC) is highly prevalent in patients with CKD undergoing dialysis 4 – 6 ) . Even in pre-dialysis patients with CKD, the high prevalence and rapid progression of VC is well recognized 7 – 10 ) . In addition, the presence and progression of VC is closely related to the increased morbidity and mortality of CVD 11 – 15 ) .…”

Section: Introductionmentioning

confidence: 99%

Impact of Renal Functional/Morphological Dynamics on the Calcification of Coronary and Abdominal Arteries in Patients with Chronic Kidney Disease

Ichii

Morimoto

Okumura

et al. 2017

JAT

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Aim: Fast-progressing vascular calcification (VC) is accompanied by renal atrophy and functional deterioration along with atherosclerosis in patients with chronic kidney disease (CKD). However, the relationship between VC progression and renal functional and/or morphological changes remains unclear.Methods: We included 70 asymptomatic patients with CKD without hemodialysis in our study. To identify temporal variations, the coronary artery calcification score (CACS), abdominal aortic calcification index (ACI), and renal parenchymal volume index (RPVI) were determined via spiral computed tomography scans taken during the study. We investigated significant factors related to annualized variations of CACS (ΔCACS/y) and ACI (ΔACI/y).Results: During the follow-up period (4.6 years), median values of CACS [in Agatston units (AU)] and ACI increased from 40.2 to 113.3 AU (p = 0.053) and from 13.2 to 21.7% (p = 0.036), respectively. Multivariate analysis revealed that CACS at baseline (p < 0.001) and diabetes mellitus (DM) status (p = 0.037) for ΔCACS/y and ACI at baseline (p = 0.017) and hypertension (HT) status (p = 0.046) for ΔACI/y were significant independent predictors. Furthermore, annualized RPVI variation was significantly related to both ΔCACS/y and ΔACI/y (R = −0.565, p < 0.001, and R = −0.289, p = 0.015, respectively). On the other hand, independent contributions of the estimated glomerular filtration rate (eGFR) and annualized eGFR variation to VC progression were not confirmed.Conclusion: The degree of VC at baseline, DM, HT, and changes in renal volume, but not eGFR, had a strong impact on VC progression in patients with CKD.

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Predictors of abdominal aortic calcification progression in patients with chronic kidney disease without hemodialysis

Cited by 17 publications

References 35 publications

The predictive value of serum galectin 3 for abdominal aortic calcification in maintenance hemodialysis patients: A prospective cohort study

The predictive value of serum galectin 3 for abdominal aortic calcification in maintenance hemodialysis patients: A prospective cohort study

Impact of Diabetes Mellitus on the Aortic Wall Changes as Atherosclerosis Progresses: Aortic Dilatation and Calcification

Impact of Renal Functional/Morphological Dynamics on the Calcification of Coronary and Abdominal Arteries in Patients with Chronic Kidney Disease

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