Predictors of 1‐ and 2‐year mortality in patients with rectal cancer

Quintana, José M.; González, Nerea; Lázaro, Santiago; Baré, Marisa; Fernández-de-Larrea, Nerea; Redondo, Maximino; Briones, Eduardo; Escobar, Antonio; Sarasqueta, Cristina; García-Gutiérrez, Susana; Antón-Ladislao, Ane

doi:10.1111/codi.14250

Cited by 8 publications

(5 citation statements)

References 22 publications

(23 reference statements)

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“…There was a significant association of Wnt-11 expression and patient mortality at 5 years, but only when considering patient tumors with very high Wnt-11 (12% of the patients in this cohort). We also noted an inverse relationship between Wnt-11 and the Charlson Comorbidity Index, a factor for poor prognosis in rectal cancer patients in Spain [34] and in this patient cohort (Table S5). Thus, it appears that patients with high Wnt-11 have fewer co-morbidities, which may confound an association of Wnt-11 with increased mortality resulting from colorectal cancer.…”

Section: Discussionmentioning

confidence: 58%

Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer

Gorroño-Etxebarria

Aguirre

Sánchez

et al. 2019

Cancers

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The expression of the secreted factor Wnt-11 is elevated in several types of cancer, including colorectal cancer, where it promotes cancer cell migration and invasion. Analysis of colorectal cancer gene expression databases associated WNT11 mRNA expression with increased likelihood of metastasis in a subset of patients. WNT11 expression was correlated with the expression of the Wnt receptors FZD6, RYK, and PTK7, and the combined expression of WNT11, FZD6 and RYK or PTK7 was associated with an increased risk of 5-year mortality rates. Immunohistochemical analysis of Wnt-11 in a cohort of 357 colorectal cancer patients found significantly higher Wnt-11 levels in tumors, compared with benign tissue. Elevated Wnt-11 levels occurred more frequently in rectal tumors than in colonic tumors and in tumors from women than men. In univariate analysis, increased Wnt-11 expression was also associated with tumor invasion and increased 5-year mortality. High Wnt-11 levels were not associated with high levels of nuclear β-catenin, suggesting Wnt-11 is not simply an indicator for activation of β-catenin-dependent signaling. Expression of Wnt-11 in colorectal cancer cell lines expressing low endogenous Wnt-11 inhibited β-catenin/Tcf activity and increased ATF2-dependent transcriptional activity. WNT11 gene silencing and antibody-mediated inhibition of Wnt-11 in colorectal cancer cell lines expressing high Wnt-11 reduced their capacity for invasion. Together, these observations suggest that Wnt-11 could be a potential target for the treatment of patients with invasive colorectal cancer.

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Section: Discussionmentioning

confidence: 58%

Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer

Gorroño-Etxebarria

Aguirre

Sánchez

et al. 2019

Cancers

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“…Previous reports have demonstrated the impact of comorbidities using the CCI on OS postoperatively in several malignant diseases [11–32, 39–74] (Table 8). In HCC patients, previous retrospective studies demonstrated the association between the CCI and prognosis after surgery [73, 74].…”

Section: Discussionmentioning

confidence: 99%

“…Because aging has been determined to influence prognosis, the age‐adjusted CCI (ACCI) was developed to correct the final score of the CCI [10]. Several studies have demonstrated the clinical impact of the ACCI in patients with various types of malignant diseases [11–32]. However, there have been no studies investigating the prognostic impact of the ACCI on short‐ and long‐term outcomes in patients with HCC.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of the Age‐Adjusted Charlson Comorbidity Index for Outcomes After Hepatic Resection of Hepatocellular Carcinoma

et al. 2020

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Background This study aimed to evaluate the impact of the age-adjusted Charlson comorbidity index (ACCI) on outcomes after hepatic resection for hepatocellular carcinoma (HCC). Methods We assessed 763 patients who underwent hepatic resection for HCC. The ACCI scores were categorized as follows: ACCI B 5, ACCI = 6, and ACCI C 7. Results A multivariate analysis showed that the odds ratios for postoperative complications in ACCI = 6 and ACCI C 7 groups, with reference to ACCI B 5 group, were 0.71 (p = 0.41) and 4.15 (p \ 0.001), respectively. The hazard ratios for overall survival of ACCI = 6 and ACCI C 7 groups, with reference to ACCI B 5 group, were 1.52 (p = 0.023) and 2.45 (p \ 0.001), respectively. The distribution of deaths due to HCC-related, liver-related, and other causes was 68.2%, 11.8%, and 20% in ACCI B 5 group, 47.2%, 13.9%, and 38.9% in ACCI = 6 group, and 27.3%, 9.1%, and 63.6% in ACCI C 7 group (p = 0.053; ACCI B 5 vs. = 6, p = 0.19; ACCI = 6 vs. C 7, p \ 0.001; ACCI B 5 vs. C 7). In terms of the treatment for HCC recurrence in ACCI B 5, ACCI = 6, and ACCI C 7 groups, adaptation rate of surgical resection was 20.1%, 7.3%, and 11.1% and the rate of palliative therapy was 4.3%, 12.2%, and 22.2%, respectively. Conclusions The ACCI predicted the short-term and long-term outcomes after hepatic resection of HCC. These findings will help physicians establish a treatment strategy for HCC patients with comorbidities.

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“…Perineural invasion is a pathological process in which the tumor in ltrates the nerve structure and spreads along the nerve sheath 23 . The perineural invasion has been served as an important risk factor related to recurrence and a low survival rate in colorectal cancers and other cancers [24][25][26] . Perineural invasion is also being used as a novel target to block tumor progression and improve survival 23 .…”

Section: Serum Cea Status and Metastatic Sitesmentioning

confidence: 99%

Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients

Chen

Wang

et al. 2020

Preprint

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It is rare and understudied for patients with stage T1 colorectal cancer to have synchronous distant metastasis. This study was to determine the clinicopathological factors associated with distant metastasis and prognosis. T1 colorectal cancer patients diagnosed between 2010 and 2015 were obtained from the SEER database. Logistic regression was applied to determine risk factors related to distant metastasis. Cox-proportional hazard models were used to identify the prognostic factors for patients with distant metastasis. Among 21,321 patients identified, 359 (1.8%) had synchronous distant metastasis and 1807 (8.5%) had lymph node metastasis. Multivariate analysis revealed that younger age, positive serum CEA, larger tumor size, positive tumor deposit, perineural invasion, lymph node metastasis, histology of non-adenocarcinoma and poorer differentiation were significantly associated with the increased risk of synchronous distant metastasis. Older age, female, African American, positive CEA, positive lymph node metastasis, positive tumor deposit, larger tumor size, no chemotherapy, inadequate lymph node harvesting and no metastasectomy were correlated with worse survival in these patients with synchronous distant metastasis. Patients with metastasis to the liver displayed the highest rate of positive CEA. We conclude that T1 colorectal cancer patients with multiple risk factors need thorough examinations to exclude synchronous distant metastasis. Chemotherapy, adequate lymph node cleaning and metastasectomy are associated with improved survival for those patients with distant metastases. Positive serum CEA may be useful in predicting distant metastases in patients at stage T1.

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Predictors of 1‐ and 2‐year mortality in patients with rectal cancer

Abstract: These clinical parameters show good predictive values and are easy and quick-to-use tools to help in clinical decision making.

Cited by 8 publications

References 22 publications

Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer

Wnt-11 as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer

Predictive Value of the Age‐Adjusted Charlson Comorbidity Index for Outcomes After Hepatic Resection of Hepatocellular Carcinoma

Clinicopathological factors associated with synchronous distant metastasis and prognosis of stage T1 colorectal cancer patients

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