Predictors associated with mortality of veno-venous extracorporeal membrane oxygenation therapy

Abstract

Background: The use of veno-venous extracorporeal membrane oxygenation (V-V ECMO) has rapidly increased in recent years. Today, applications of V-V ECMO include a variety of clinical conditions such as acute respiratory distress syndrome (ARDS), bridge to lung transplantation and primary graft dysfunction after lung transplantation. The purpose of the present study was to investigate in-hospital mortality of adult patients undergoing V-V ECMO therapy and to determine independent predictors associated with mortality.Methods: This retrospective study was conducted at the University Hospital Zurich, a designated ECMO center in Switzerland. Data was analyzed of all adult V-V ECMO cases from 2007 to 2019.Results: In total, 221 patients required V-V ECMO support (median age 50 years, 38.9% female).In-hospital mortality was 37.6% and did not statistically vary significantly between indications (P=0.61): 25.0% (1/4) for primary graft dysfunction after lung transplantation, 29.4% (5/17) for bridge to lung transplantation, 36.2% (50/138) for ARDS and 43.5% (27/62) for other pulmonary disease indications.Cubic spline interpolation showed no effect of time on mortality over the study period of 13 years. Multiple logistic regression modelling identified significant predictor variables associated with mortality: age [odds ratio (OR), 1.05; 95% confidence interval (CI): 1.02-1.07; P=0.001], newly detected liver failure (OR, 4.83;

Prognostic factors in lung transplantation after extracorporeal membrane oxygenation bridging therapy: a systematic review and meta-analysis

“…The initial search yielded 12,886 records, culminating in the inclusion of eight eligible trials ( 22 - 29 ) in the final meta-analysis ( Figure 1 ). The methodological quality evaluation scores of these eight studies were six points or higher, indicating high quality.…”

A Descriptive Analysis of Hybrid Cannulated Extracorporeal Life Support

“…We recently published our outcome analysis of 679 V-A [19] and 221 V-V [20] ECLS cases. The frequency of hybrid ECLS in our institution (3%) is in line with published data of ELSO [13] (2% of adults supported for cardiac failure and less than 1% for respiratory failure).…”