Predictors and microbiology of respiratory and bloodstream bacterial infection in patients with COVID-19: living rapid review update and meta-regression

Langford, Bradley J; So, Miranda; Leung, Valerie; Raybardhan, Sumit; Lo, Jennifer; Kan, Tiffany; Leung, Felicia; Westwood, Duncan; Daneman, Nick; MacFadden, Derek R.; Soucy, Jean‐Paul

doi:10.1016/j.cmi.2021.11.008

Cited by 57 publications

(62 citation statements)

References 176 publications

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“…As expected, the presence of pressure ulcers depends on the duration of intubation, as the longer the period of invasive mechanical ventilation the higher the risk. Likewise, ICU setting and mechanical ventilation are risk factors for development of secondary bacterial infections [ 23 ]. In turn, such infections can result in a prolonged period of mechanical ventilation and ICU stay, and an increased mortality rate [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Lack of direct association between oral mucosal lesions and SARS-CoV- 2 in a cohort of patients hospitalised with COVID-19

Schwab

Palmieri

Zerbinati

et al. 2022

Journal of Oral Microbiology

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Background COVID-19 is a disease affecting various human organs and systems, in which the virus seeks to interact with angiotensin-converting enzyme 2 receptors. These receptors are present in the oral cavity, but the direct relationship between such an interaction and possible oral manifestations of COVID-19 is still unclear. Aim The present study evaluated oral manifestations in a cohort of COVID-19 patients during the period of hospitalisation. Methods In total, 154 patients presenting moderate-to-severe forms of COVID-19 had their oral mucosa examined twice a week until the final outcome, either discharge or death. The oral alterations observed in the patients were grouped into Group 1 (pre-existing conditions and opportunistic oral lesions) and Group 2 (oral mucosal changes related to hospitalization). Results Oral lesions found in the patients of Group 1 are not suggestive of SARS-CoV-2 infection as they are mainly caused by opportunistic infections. On the other hand, oral alterations found in the patients of Group 2 were statistically ( P < 0.001) related to intubation and longer period of hospitalisation. Conclusion It is unlikely that ulcerative lesions in the oral cavity are a direct manifestation of SARS-CoV-2 or a marker of COVID-19 progression.

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Section: Discussionmentioning

confidence: 99%

Lack of direct association between oral mucosal lesions and SARS-CoV- 2 in a cohort of patients hospitalised with COVID-19

Schwab

Palmieri

Zerbinati

et al. 2022

Journal of Oral Microbiology

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“…We analyzed the baseline characteristics in the infected and control groups that may be related to infection [21][22][23], including gender, age, days of hospitalization, clinical stage, number of admissions, surgery, intraoperative bleeding, chemotherapy, radiotherapy, and other characteristics. Our study revealed that hospitalization days ≥7 days, number of days ≥7 days, surgery, and chemotherapy were the independent risk factors for E. coli BSI.…”

Section: Discussionmentioning

confidence: 99%

Clinical Analysis of Bloodstream Infection of Escherichia coli in Patients with Pancreatic Cancer from 2011 to 2019

Bai

Zhang

Yang

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Pancreatic cancer patients were particularly predisposed to develop Escherichia coli (E. coli) bloodstream infection (BSI); however, little information is currently available. We set out to find E. coli BSI’s risk factors in pancreatic cancer to provide valuable experience. Methods. We retrospectively analyzed the clinical data of pancreatic cancer patients (31 cases with E. coli BSI and 93 cases without BSI) by a case-control study. SPSS 17.0 was adopted to perform univariate and multivariate analyses. Bacterial resistance analysis was performed by Whonet 5.6. Results. Hospitalization days ≥7 days, number of admissions ≥2 times, surgery, chemotherapy, the type of antibiotics used ≥2 species, albumin<40.0 g/L, and prealbumin < 0.2 g/L were the potential risk factors for pancreatic cancer patients with E. coli BSI ( P < 0.1 ). Multivariate logistic regression showed hospitalization days ≥7 days (OR = 11.196, 95% CI = 0.024–0.333, P < 0.001 ), surgery (OR = 32.053, 95% CI = 0.007–0.137, P < 0.001 ), and chemotherapy (OR = 6.174, 95% CI = 0.038–0.688, P = 0.014 ) were the independent risk factors for E. coli BSI of pancreatic cancer patients. E. coli resistant to carbapenems was rare; they were susceptible to cephamycin and piperacillin/tazobactam. The 90-day mortality rate of the infected group was significantly higher than the control group (41.9% versus 8.6%, P < 0.001 ). Conclusions. Hospitalization days ≥7 days, surgery, and chemotherapy are the independent risk factors for E. coli BSI of pancreatic cancer patients, which allows us to identify patients at potential risk and perform preventive treatment in time.

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“…Bradley J Langford, BScPhm, PharmD 1,2 Miranda So, BScPhm, PharmD, MPH 3,4,5 Valerie Leung, BScPhm, MBA 1,6 Sumit Raybardhan, BScPhm, MPH 7 Jennifer Lo, BScPhm, PharmD 8 Tiffany Kan, BScPhm, PharmD 6 Felicia Leung, HBSc 4 Nick Daneman, MD, MSc 1,4,8,10,11 Derek R MacFadden, MD, ScD 12 Jean-Paul R Soucy, MSc 9…”

Section: 'Predictors and Microbiology Of Respiratory And Bloodstream ...mentioning

confidence: 99%

“…To the Editor, We thank the authors for their interest and comments regarding our publication in CMI [1]. Given the vast amount of literature published on the topic of co-infections and secondary infections in COVID-19, and the heterogeneity in publication quality, methodological approach, and data reporting strategies, it was necessary to make some assumptions regarding whether studies met inclusion criteria.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Predictors and microbiology of respiratory and bloodstream bacterial infection in patients with COVID-19: author's response

Langford

Leung

et al. 2022

Clinical Microbiology and Infection

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Predictors and microbiology of respiratory and bloodstream bacterial infection in patients with COVID-19: living rapid review update and meta-regression

Cited by 57 publications

References 176 publications

Lack of direct association between oral mucosal lesions and SARS-CoV- 2 in a cohort of patients hospitalised with COVID-19

Lack of direct association between oral mucosal lesions and SARS-CoV- 2 in a cohort of patients hospitalised with COVID-19

Clinical Analysis of Bloodstream Infection of Escherichia coli in Patients with Pancreatic Cancer from 2011 to 2019

Predictors and microbiology of respiratory and bloodstream bacterial infection in patients with COVID-19: author's response

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