Predictors and Impact of Major Hemorrhage on Mortality Following Percutaneous Coronary Intervention from the REPLACE-2 Trial

Feit, Frederick; Voeltz, Michele; Attubato, Michael; Lincoff, A. Michael; Chew, Derek P.; Bittl, John A.; Topol, Eric J.; Manoukian, Steven V.

doi:10.1016/j.amjcard.2007.06.026

Cited by 310 publications

(220 citation statements)

References 19 publications

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“…In addition, we found that women had a significantly higher rate of dissection (3.3 vs. 7.2 %, p < .003) and bleeding complication (0.4 vs. 1.5 %, p = .044) in the ICgroup. The latter was previously found in several other studies, revealing more bleeding complications for female gender when undergoing percutaneous coronary intervention [17]. This might be due to a diff erence in the pharmacokinetics of heparin in women [18].…”

Section: Discussionsupporting

confidence: 58%

Gender differences in endovascular treatment of infrainguinal peripheral artery disease

Rieß

Debus

Heidemann

et al. 2017

Vasa

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Summary:Background: Despite ongoing research concerning comorbidities and clinical presentation of peripheral arterial disease (PAD), the issue of gender associated differences in treatment is far from being settled. Patients and methods: This was a prospective, non-randomized multicentre study design. All patients suffering from intermittent claudication (IC) or critical limb ischaemia (CLI) were included. Results: A total of 2,798 procedures for symptomatic PAD in the infrainguinal region were recorded, with 1,696 (61.4 %) males. Distribution of comorbidities for patients with IC were gender-specifi cally different. Smoking was more common in men (41.9 vs. 31.9 %, p < .001), men had more often previous coronary heart disease (35.2 vs. 27.7 %, p = .007), and suffered more often from diabetes (33.9 vs. 28.2 %, p = .037). Women were generally older (71 vs. 77 years). Men were more prone to present with IC (46.9 vs. 43.6 %, p < .001) and ulcer/gangrene (43.6 vs. 41.2 %, p < .001). Women were more likely to present with rest pain (9.5 vs. 15.1 %, p < .001). Men were more often treated for a lesion below the knee (BTK) (21.1 vs. 14.9 %, p < .001), and females above the knee (ATK) (58.1 vs. 61.5 %, p < .001). Logistic regression analysis revealed a signifi cant association of male gender and treatment for lesions BTK (OR 1.565, 95 % CI 1.281-1.913, p < .001). Dissections and bleeding complications were more often observed in females with IC (3.3 vs. 7.2 %, p = 0.003; 0.4 vs. 1.5 %, p = 0.044). Women were rather discharged to rehabilitation and had a longer hospital stay compared to men (3.4 vs. 8.9 %, p < .001; three vs. four days, p = .023). Conclusions: The present study provides an overview on gender-specifi c differences in endovascular treatment of PAD. To date, available evidence on this topic is limited, emphasising the importance of further vascular research targeting this topic.

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Section: Discussionsupporting

confidence: 58%

Gender differences in endovascular treatment of infrainguinal peripheral artery disease

Rieß

Debus

Heidemann

et al. 2017

Vasa

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“…19 Patients with renal insufficiency form a large portion of the ACS patient population, with a prevalence varying from 13.2% for patients with GFR below 30 ml/min to 42% for patients with GFR between 30 and 70 ml/min. 23,24 Furthermore, it has been shown that patients with renal failure benefit from an invasive strategy, although they are in fact at higher risk for bleeding, especially when dose restriction is not applied. 25 Patients aged 75 years and above Age above 75 years has been shown to be an independent risk factor for bleeding complications and worse outcome.…”

Section: Renal Failurementioning

confidence: 99%

Guideline adherence for antithrombotic therapy in acute coronary syndrome: an overview in Dutch hospitals

Kikkert

Piek²,

Winter³

et al. 2010

NHJL

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Objective. To assess current Dutch antithrombotic treatment strategies for acute coronary syndrome (ACS) in light of the current European Society of Cardiology (ESC) guidelines. Methods. For every Dutch hospital with a coronary care unit (CCU) (n = 93) a single cardiologist was interviewed concerning heparin, thienopyridine and GP IIb/IIIa inhibitor (GPI) treatment. In each hospital, we randomly approached one cardiologist assuming equal policy among physicians employed at the same hospital.

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“…Sin embargo, la variabilidad anatómica y de tamaño, así como la inadecuada irrigación colateral, no siempre hacen posible el acceso por esta arteria [1][2][3][4][5][6] . Desde que en el 2001 Terashima 7 reportara el uso de la arteria cubital o ulnar para diagnóstico y terapia coronaria, esta arteria se ha transformado en una alternativa en pacientes seleccionados aún cuando las características anatómicas, principalmente la cercanía con el nervio cubital y su profundidad la hacen potencialmente propensa a complicaciones diferentes a las de la arteria radial.…”

Section: Introductionunclassified

Acceso por vía cubital como alternativa al acceso radial para diagnóstico e intervenciones coronarias: serie de 29 pacientes

Méndez

Pérez

León³

et al. 2011

Rev Chil Cardiol

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Predictors and Impact of Major Hemorrhage on Mortality Following Percutaneous Coronary Intervention from the REPLACE-2 Trial

Cited by 310 publications

References 19 publications

Gender differences in endovascular treatment of infrainguinal peripheral artery disease

Gender differences in endovascular treatment of infrainguinal peripheral artery disease

Guideline adherence for antithrombotic therapy in acute coronary syndrome: an overview in Dutch hospitals

Acceso por vía cubital como alternativa al acceso radial para diagnóstico e intervenciones coronarias: serie de 29 pacientes

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