Predictors and health-related quality of life with short form-36 for multidrug-resistant tuberculosis patients in Jambi, Indonesia: A case-control study

Abstract

Background: Multidrug-resistant tuberculosis (MDR-TB) is another problem in TB elimination. In 2018, 484,000 people worldwide developed tuberculosis that was resistant to rifampicin, and 78% of those had MDR-TB. Estimation of risk factors to detect MDR-TB. Methods: A case-control study assesses the estimate of the socio-demographic, house environment, diabetes mellitus, treatment behavior, and health-related quality of life (HRQOL). There were 28 cases of MDR-TB patients, and 56 control of drug-susceptible tuberculosis (DS-TB), in the treatment phase of October 1, 2019 to March 31, 2020. Results: The analysis showed a diabetes mellitus (adjusted odds ratio [AOR] 4.06, 95% confidence interval [CI] 1.31-12.54), treatment adherence (AOR 3.67, 95% CI 1.26-10.69), and supervisor of drugs swallowing (AOR 3.55, 95% CI 1.06-11.86) as a risk predictor for MDR-TB, and HRQOL independently associated with the incidence of MDR-TB (crude odds ratio [COR] 4.08, 95% CI 1.19-13.98), whereas socio-demographic and house environment was not a risk factor in this study. Validity and reliability of the SF-36 questionnaire (intraclass correlation coefficient [ICC], 0.658-0.802; Cronbach's α coefficient, 0.864). Conclusion:Diabetes mellitus, treatment adherence, supervisor of drugs swallowing as a risk predictor for MDR-TB. HRQOL of patients with MDR-TB was lower. The SF-36 questionnaire is valid and reliable to measure the HRQOL for TB/MDR-TB patients.

Tuberculosis impacts multiple aspects in quality of life in a Romanian cohort of drug‐susceptible and drug resistant patients: A patient‐reported outcome measures study

“…Joint pain is a reported side effect of second‐line TB drugs, including bedaquiline [25]; however, other studies using the SF‐36 found that pain was less significant in the MDR‐TB group [26] than in the DS‐TB group. At the same time, patients included in our study reported better quality of life outcomes than patients in other studies, especially concerning DR‐TB [7, 26–29]. As in our study, other research showed improvement in quality of life after the completion of TB treatment, especially visible on the EQ‐5D‐5L general health visual analogue scale.…”

A randomized controlled trial to evaluate the impact of pharmacist-led clinical interventions on the health-related quality of life among TB patients

“…Female patients are the most neglected population in society, possibly due to the high levels of stigma and discrimination against them in Pakistan ( Habib et al, 2021 ). As a result, gender is an important social predictor of health, and inequalities in gender-related HRQoL parameters must be considered ( Izhar et al, 2021 ). In this study, in the control group, smoking was identified to interact with the trend of the HRQoL of TB patients.…”

Hubungan karakteristik individu dan kondisi fisik rumah dengan kejadian tuberkulosis paru

“…Risiko penyakit tuberkulosis untuk kelompok dengan status ekonomi di bawah upah minimum adalah 7,667 kali lebih berisiko dibandingkan kelompok dengan status ekonomi di atas upah minimum (Sejati & Hidayanti, 2020). Riwayat diabetes dengan kejadian tuberkulosis memiliki hubungan yang bermakna sebesar 3,45 kali (Izhar, Butar, Hidayati, & Ruwayda, 2021). Variabel riwayat kontak keluarga serumah dengan kejadian tuberkulosis paru menunjukkan hubungan statistik antara riwayat kontak keluarga serumah dengan kejadian tuberkulosis paru dengan nilai OR 3,50 (Alnur & Pangestika, 2018).…”