Predictor factors of inappropriate rivaroxaban dosage using the Ckd-Epi equation

Cabeza, Alejandro Isidoro Pérez; Górriz, José Luis; Marqués, Rafael Bravo; Capote, Pedro Antonio Chinchurreta; Tejero, Sergio López; Correa, José Antonio González; Prado, Fidel Ernesto Mesa; Alberca, Almudena Valle; Mateas, Francisco Ruíz

doi:10.1016/j.nefroe.2021.04.002

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…There were studies demonstrating inconsistence of renal function estimation using different equations in AF patients. [35][36][37][38] Misclassification of renal function status in AF patients using the MDRD and CKD-EPI equations was mostly observed, 37,38 and may have harmful effect on prognosis because of potential off-label dosing of NOACs. 37 Therefore, the CG equation is recommended for correct dosing of NOACs.…”

Section: The Role Of Renal Function Equations In Differentiating Clin...mentioning

confidence: 99%

The Impacts of Oral Anticoagulants on Clinical Outcomes in Patients with Atrial Fibrillation Across Five Stages of Renal Function

Liao,

Chan,

Lee

et al. 2024

Preprint

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Background: To analyze the impact of using different renal function equations and stroke prevention strategy in atrial fibrillation (AF) across all chronic kidney disease (CKD) stages. Methods: We used the Cockcroft-Gault (CG), Modified Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations to classify 39,217 patients into stage 1 to 5 CKD during July 1st, 2001, and September 30st, 2018. The endpoint is a composite outcome including ischemic stroke or major bleeding or mortality. Results: More patients belonged to stage 1 and 2 CKD using the MDRD and CKD-EPI equations. In subgroups of patients with eGFR-MDRD or eGFR-CKD-EPI ? 60 mL/min, a 17-18% increase of event was observed in patients with eGFR-CG < 60 mL/min compared to those ? 60 mL/min. Compared to no oral anticoagulant (OAC), OAC use was associated with a significantly lower risk of event across stage 1 to 4 CKD but not in stage 5 CKD. Both warfarin and NOACs exhibited better outcome compared to no OAC across stage 1 to 4 CKD while NOACs was associated with more risk reduction compared to warfarin. Among patients on OACs, there was a trend toward better outcome with NOAC than warfarin across stage 2-4 CKD but not in stage 1 and 5 CKD. Conclusions: OAC should be used in stage 1 to 4 CKD with NOAC exhibiting the trend of better outcome through stage 2 to 4 CKD than warfarin. For stage 5 CKD, optimal strategy remains undetermined.

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Section: The Role Of Renal Function Equations In Differentiating Clin...mentioning

confidence: 99%

The Impacts of Oral Anticoagulants on Clinical Outcomes in Patients with Atrial Fibrillation Across Five Stages of Renal Function

Liao,

Chan,

Lee

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Habitualmente, la mayoría de los ensayos clínicos han usado la fórmula Cockcro‚-Gault, que suele sobreesVmar este valor (329), recomendando las guías de prácVca clínica habitual el empleo de CKDEPI. Un grupo español reportó hasta un 7% de cambios de dosis de rivaroxabán según el empleo de una u otra fórmula, en su mayoría por sobredosificación y, basándose en sus hallazgos, generó una escala para predecir qué pacientes tendrían más probabilidad de recibir una dosis inadecuada y en los que se aconsejaría un cálculo específico de la FG de forma directa (433). Junto a este hecho, la tendencia de los pacientes con ERC a la progresión de la enfermedad, así como las variaciones en la función suscepVbles de la situación hemodinámica, pueden generar un empeoramiento de la función renal, asociando mayor probabilidad de mala dosificación, incrementándose el riesgo de sangrado (422).…”

Section: Terapia Angcoagulante En Ercunclassified

Cierre percutáneo de la orejuela izquierda en pacientes con enfermedad renal crónica avanzada (estadios 4, 5 y diálisis)

López Tejero

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Predictor factors of inappropriate rivaroxaban dosage using the Ckd-Epi equation

Cited by 2 publications

References 5 publications

The Impacts of Oral Anticoagulants on Clinical Outcomes in Patients with Atrial Fibrillation Across Five Stages of Renal Function

The Impacts of Oral Anticoagulants on Clinical Outcomes in Patients with Atrial Fibrillation Across Five Stages of Renal Function

Cierre percutáneo de la orejuela izquierda en pacientes con enfermedad renal crónica avanzada (estadios 4, 5 y diálisis)

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