Predictive variables of spontaneous micturition recovery after acute urinary retention in men with benign prostatic enlargement: An observational prospective study

Vella, Marco; Abrate, Alberto; Costanzo, Angela; D’Amato, Francesco; Tarantino, María; Simonato, Alchiede

doi:10.1111/luts.12241

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…CRP is an acute phase protein secreted by IL-6 that is upregulated during various inflammatory processes, tissue necrosis, and tissue damage (such as after surgery) [ 21 ]. Thus, serum CRP has been demonstrated to be a predictor due to an increase of its serum level in acute urinary retention, [ 22 ] acute prostatitis [ 23 ], and liver cirrhosis [ 24 ]. IL-2 regulates the cellular activity of white blood cells in the immune system [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

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The Clinical Effect and Mechanism of Prostant on Urinary Retention and Anal Pain

Luo

Jiang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Anal pain and urinary retention are the two most outstanding complications of the procedure for prolapse and hemorrhoids (PPH) surgery. This study intended to assess the clinical effect and mechanism of Prostant on urinary retention and anal pain after the PPH. Here, 30 patients received PPH surgery. The role and mechanism of Prostant in patients and mice with urinary retention and anal pain were evaluated. ANOVA tests were executed and differences between groups were regarded as statistically significant when p < 0.05 . Prostant effectively improved the urination status, lower abdomen symptoms, time to urinate and score of VAS, and the reduction of TNF-α and IL-6. Similarly, Prostant can ameliorate the outcome of urodynamics in urinary retention mice. Mechanically, Prostant reversed the urinary retention-elevated the serum level of hs-CRP and TNF-α, reduction of IL-2, imbalance of Treg/Th17, and level of JAK2 and phosphorylated STAT3. Besides, Prostant ameliorated the pain as shown by the reduction of writhing response, and the elevation of threshold of pain and degree of swelling. Moreover, Prostant antagonized the pain-induced dysregulation of Treg/Th17. Therefore, Prostant can treat patients and mice with anal pain and urinary retention by modulating the balance of Th17/Treg to regulate the secretion and production of inflammatory factors. We hope our results can establish a scientific treatment approach for solving anal pain and urinary retention after PPH surgery of mixed hemorrhoids.

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Section: Discussionmentioning

confidence: 99%

“…e means ± SD of six independent samples were displayed. In Figures Evidence-Based Complementary and Alternative Medicine serum level in acute urinary retention, [22] acute prostatitis [23], and liver cirrhosis [24]. IL-2 regulates the cellular activity of white blood cells in the immune system [25].…”

Section: Discussionmentioning

confidence: 99%

The Clinical Effect and Mechanism of Prostant on Urinary Retention and Anal Pain

Luo

Jiang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Portanto, devido ao caráter anti-androgênico, anti inflamatório, anti proliferativo, antiedematoso e antioxidante, verifica-se que plantas medicinais podem ser utilizadas no tratamento de doenças da próstata, como hipertrofia prostática benigna, prostatite e síndrome da dor pélvica crônica (CICERO, A. et al, 2019), além de retenção urinária aguda (VELLA, et al 2019).…”

Section: Introductionunclassified

As Novas Faces Da Saúde: Tecnologia E Multidisciplinaridade No Contexto Atual

2022

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Saúde, que vem do latim salud, significa conservação da vida, cura. O livro "As novas faces da saúde: tecnologia e multidisciplinaridade no contexto atual" tem o objetivo de informar sobre todos os aspectos que envolvem a saúde, o processo de cura e prevenção. Hoje, sabemos que o significado de saúde não abrange somente a ausência da doença, mas sim todo um conjunto. Segundo a Organização Mundial de Saúde (OMS), o termo está relacionado a um bem-estar físico, mental, espiritual e social.Nesse sentido, a tecnologia e a multidisciplinaridade são aspectos essenciais que colaboram na obtenção de uma melhor qualidade de vida, além de facilitar os processos diagnósticos e preventivos e estabelecer assim, condições em saúde.Diante disso, na segunda edição do Congresso Interdisciplinar da Área Médica (CIAM), trouxemos diversas reflexões sobre a Interdisciplinaridade, Saúde Integral, e a importância da tecnologia nesse meio, o que se adequa com as ideias contidas nesse livro. As reflexões que queremos trazer são as desse aspecto integrativo e multidisciplinar que engloba todos os fatores que colaboram para a garantia de saúde, assim como a interação de vários profissionais, cada um dentro da sua área de atuação, mas que se complementam no contexto atual.Os organizadores.

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“…In this scenario, an increasing interest on the role of phytotherapeutic and nutraceutical agents either as alternative or in addition to conventional therapy for the management of BPH has evolved during the last decades [7][8][9]. Particularly, if on the one hand Serenoa repens (SeR) represents nowadays one of the most promising extracts [10], on the other hand several recent clinical trials assessed its effectiveness and safety as first-line approach as monotherapy or in combination with other nutraceutical elements such as selenium (Se) and lycopene (Ly) [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Impact of the Treatment of Serenoa repens, Solanum lycopersicum, Lycopene and Bromelain in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison Analysis

Lambertini

Maida

Tellini

et al. 2021

Uro

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Background: Phytotherapeutic agents aroused an increasing interest either as alternative or in addition to conventional therapy in the management of BPH. The aim of the article was to evaluate the clinical and functional changes after add-on treatment with Serenoa repens associated with Solanum lycopersicum, lycopene and bromelain in patients with BPH presenting with mild to moderate LUTS and previously treated only with Alfuzosin over a 6–12 months period. Materials and methods: Between January and July 2019, patients with symptomatic BPH already on treatment with Alfuzosin (Al) 10 mg for at least 6–12-month were enrolled at three academic referral centres, included in a prospective treatment group, and managed with a combination treatment of Al and 6-month daily oral single-tablet supplementation of Serenoa repens and Solanum lycopersicum + lycopene + bromelain (SeR + SL + Ly + Br). A retrospective control group with comparable baseline characteristics was obtained by performing a propensity score matching from a database of 434 patients managed with Alfuzosin 10 mg/day only over a 6–12 months period between March 2015 and December 2018. IPSS, QoL questionnaires, voiding diary assessment, postvoid residual volume (PVR), maximal (Qmax) and average (Qave) urinary flow rates were evaluated at baseline in the treatment group at the moment of patient accrual, in the control group after 6-month of treatment with alfuzosin, and thereafter at 3 and 6 months in both groups. Results: Overall, 250 patients entered the study (n = 125 treatment group; n = 125 control group). Total IPSS score significantly decreased at 6-month assessment from baseline in the treatment vs control group (17 [IQR: 12–20] vs 12 [IQR: 9–14], p = 0.02) with a significative storage symptoms improvement detected both at 3- (p = 0.03) and 6-month evaluation (p = 0.001). PVR significantly improved at each follow-up visit with the most relevant reduction at 6-month assessment (125 cc vs. 102 cc; p = 0.02). Moreover, a significative improvement in LUTS-related quality of life (QoL) was recorded at 3- and 6-month assessment with a median decrease of −1 and −2 (p = 0.05 and p = 0.001 respectively) from baseline. Conclusions: Combination treatment with AB and SeR + SL + Ly + Br led to meaningful improvements in LUTS severity compared to AB as monotherapy, after a 6-month treatment period in men with mild to moderate LUTS/BPH.

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Predictive variables of spontaneous micturition recovery after acute urinary retention in men with benign prostatic enlargement: An observational prospective study

Abstract: CRP and IPSS-4 could be useful tools to predict spontaneous micturition recovery after catheterization associated with medical therapy for AUR.

Cited by 5 publications

References 27 publications

The Clinical Effect and Mechanism of Prostant on Urinary Retention and Anal Pain

The Clinical Effect and Mechanism of Prostant on Urinary Retention and Anal Pain

As Novas Faces Da Saúde: Tecnologia E Multidisciplinaridade No Contexto Atual

Impact of the Treatment of Serenoa repens, Solanum lycopersicum, Lycopene and Bromelain in Combination with Alfuzosin for Benign Prostatic Hyperplasia. Results from a Match-Paired Comparison Analysis

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