Predictive values of Notch signalling in renal carcinoma

Jędroszka, Dorota; Orzechowska, Magdalena

doi:10.5114/aoms.2017.65649

Cited by 22 publications

(23 citation statements)

References 18 publications

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“…Nevertheless, long-term outcomes are still not satisfactory, particularly due to common local recurrences, distal metastases and limited drug response [6]. Under those circumstances, an improvement in RCC patients' management could be obtained by developing novel, easily obtainable and cheap prognostic markers which might help select patients who would benefit most from additional postoperative care [7,8]. It is commonly known that blood is full of tumor-associated biomarkers, such as pro-inflammatory cells, including neutrophils and platelets.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-mean platelet volume ratio as a new predictor for overall and cancer-specific survival in patients with localized clear cell renal cell carcinoma

Życzkowski

Rajwa

Burzyński

et al. 2020

aoms

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Introduction: The present study investigated the prognostic value of neutrophil-to-mean platelet volume ratio (NMPVR) for overall (OS) and cancer-specific survival (CSS) in patients treated with nephrectomy for localized clear cell renal cell carcinoma (ccRCC). Material and methods: Medical records of 344 consecutive patients who underwent partial or radical nephrectomy for M0 ccRCC were retrospectively analyzed. Based on the median NMPVR, the study population was divided into two groups: the high NMPVR group with NMPVR higher than or equal to the median, and the low NMPVR group with NMPVR lower than the median. Comparisons of baseline characteristics and laboratory and pathological findings were performed. Kaplan-Meier survival curves and Cox regression model analysis were used to assess the prognostic value of the NMPVR. Results: Patients with higher NMPVR values were more frequently diagnosed with advanced disease, tumor necrosis and higher tumor grade. The OS and CSS were significantly shorter in patients with NMPVR ≥ 0.41 compared to patients with NMPVR < 0.41. Inclusion of NMPVR in multivariable models of OS and CSS with other confounding variables determined categorized NMPVR as an independent prognostic factor for both endpoints. Conclusions: Pretreatment NMPVR ≥ 0.41 was associated with lower OS and CSS. NMPVR might be applied as a cheap and uncomplicated prognostic indicator in localized ccRCC patients treated with a primary surgical approach.

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Section: Introductionmentioning

confidence: 99%

Neutrophil-to-mean platelet volume ratio as a new predictor for overall and cancer-specific survival in patients with localized clear cell renal cell carcinoma

Życzkowski

Rajwa

Burzyński

et al. 2020

aoms

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“…According to Abrahamsen et al, invasive diagnostics are not necessary in patients with mild UA, and attentive observation is sufficient [13]. For now, it seems that research in patients with UA on the role of disorders related to notch signaling or long chain non-coding RNA is the future in prevention, prognosis or treatment, as is the case of many age-related diseases, including hematological malignancies and other cancers [26][27][28]. In our study however, during a 3-year follow-up, significantly more deaths were noted in the group with UA than in the group without anemia, even though the anemia was mild in most of the cases.…”

Section: Discussionmentioning

confidence: 99%

Unexplained anemia in the elderly – a real life analysis of 981 patients

Michalak¹,

Rupa‐Matysek²,

Hus³

et al. 2020

aoms

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Introduction: We aimed to analyze the prevalence of unexplained anemia (UA) and assess its characteristics, potential causes and impact on survival in an elderly population. Material and methods: Medical files of 981 patients aged ≥ 60 years consulted in one primary medical clinic in Poland in 2013-2014 were retrospectively analyzed. Anemia, defined according to WHO criteria, diagnosed during either hospitalization or outpatient treatment, from the age of 60, was included. Unexplained anemia was diagnosed if, based on available clinical data and laboratory tests and other assessments in medical records, none of the well-known types of anemia were identified. Results: Of 981 patients with anemia, UA was found in 48 (28.4%) patients (4.9% of those studied) and incidence increased with age (≥ 80 years, 12.3%). In 81.3% no full hematological diagnostics were performed. Patients with UA, as with those with defined anemia, when compared to the group without anemia were older, had more co-morbidities, were more frequently hospitalized, more frequently had dementia syndrome and obtained lower Barthel scores (p < 0.0001). In the groups of patients with UA and defined anemia, there were more deaths than in those without anemia (10% vs. 13% vs. 2%, p < 0.0001) with significant differences in survival rates observed during 3-year follow-up. Conclusions: The increasing incidence with age of UA in the elderly population, insufficient diagnosis and the higher mortality of patients with UA in comparison to the group without anemia indicate the need to develop recommendations for its management by primary care physicians.

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“…It was demonstrated that their levels were overly expressed in head and neck squamous cell carcinoma (HNSCC), suggesting their tumourigenic roles (as oncogenes). Recently the predictive value of Notch signalling in renal carcinoma patients has been suggested [61]. Their association with cancer was first demonstrated long before this in T-cell acute lymphoblastic leukaemia [59,62].…”

Section: Notch Proteinsmentioning

confidence: 99%

Ankyrins in human health and disease – an update of recent experimental findings

Chagula

Rechciński

Rudnicka

et al. 2020

aoms

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Ankyrins are adaptor molecules that in eukaryotic cells form complexes with ion channel proteins, cell adhesion and signalling molecules and components of the cytoskeleton. They play a pivotal role as scaffolding proteins, in the structural anchoring to the muscle membrane, in muscle development, neurogenesis and synapse formation. Dysfunction of ankyrins is implicated in numerous diseases such as hereditary spherocytosis, neurodegeneration of Purkinje cells, cardiac arrhythmia, Brugada syndrome, bipolar disorders and schizophrenia, congenital myopathies and congenital heart disease as well as cancers. Detecting either down-or over-expression of ankyrins and ergo their use as biomarkers can provide a new paradigm in the diagnosis of these diseases. This paper provides an outline of knowledge about the structure of ankyrins, and by making use of recent experimental research studies critically discusses their role in several health disorders. Moreover, therapeutic options utilizing engineered ankyrins, designed ankyrin repeat proteins (DARPins), are discussed.

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Predictive values of Notch signalling in renal carcinoma

Cited by 22 publications

References 18 publications

Neutrophil-to-mean platelet volume ratio as a new predictor for overall and cancer-specific survival in patients with localized clear cell renal cell carcinoma

Neutrophil-to-mean platelet volume ratio as a new predictor for overall and cancer-specific survival in patients with localized clear cell renal cell carcinoma

Unexplained anemia in the elderly – a real life analysis of 981 patients

Ankyrins in human health and disease – an update of recent experimental findings

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