Predictive Values of Neurocognition and Negative Symptoms on Functional Outcome in Schizophrenia: A Longitudinal First-Episode Study With 7-Year Follow-Up

Milev, Peter; Ho, Beng-Choon; Arndt, Stephan; Andreasen, Nancy C.

doi:10.1176/appi.ajp.162.3.495

Cited by 816 publications

(519 citation statements)

References 38 publications

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“…Patients with predominantly negative symptoms have poor pre-morbid adjustment during childhood or early adolescence and a low employment rate during adulthood, achieve low educational attainment and exhibit considerable cognitive impairment (Milev et al 2005;Rosenheck et al 2006;Jeppesen et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

et al. 2017

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Background. Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity. Results. Meta-analytical results showed that left, but not right, MOFC thickness was significantly associated with negative symptom severity (β std = −0.075; p = 0.019) after accounting for age, gender, and site. This effect remained significant (p = 0.036) in a model including overall illness severity. Covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left MOFC thickness. As part of a secondary analysis including 10 other prefrontal regions further associations in the left lateral orbitofrontal gyrus and pars opercularis emerged.Conclusions. Using an unusually large cohort and a meta-analytical approach, our findings point towards a link between prefrontal thinning and negative symptom severity in schizophrenia. This finding provides further insight into the relationship between structural brain abnormalities and negative symptoms in schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

et al. 2017

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“…Negative symptoms are often accompanied by cognitive deficits (Addington et al, 1991;Basso et al, 1998), worse psychosis outcome (Milev et al, 2005), social impairments (Lincoln et al, 2011;Milev et al, 2005), and poorer occupational and daily functioning (Milev et al, 2005;Rabinowitz et al, 2012). Furthermore, negative symptoms are more persistent and difficult to treat than positive symptoms, as they are not remedied by current antipsychotics (Boonstra et al, 2012;Chang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Morphological brain changes associated with negative symptoms in patients with 22q11.2 Deletion Syndrome

Mihailov

Padula

Scariati

et al. 2017

Schizophrenia Research

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Approximately 30% of individuals with 22q11.2 Deletion Syndrome (22q11DS) develop schizophrenia during adolescence/early adulthood, making this syndrome a model for the disorder. Furthermore, negative symptoms exist in up to 80% of patients diagnosed with 22q11DS. The present study aims to uncover morphological brain alterations associated with negative symptoms in a cohort of patients with 22q11DS who are at-risk for developing schizophrenia. A total of 71 patients with 22q11DS aged 12 to 35 (54% females) with no past or present diagnosis of a schizophrenia were included in the study. Psychotic symptom scores were used to divide patients into subgroups by means of a cluster analysis. Three major subgroups were evident: patients with low negative and positive symptoms; patients with high negative symptoms and low positive symptoms; and patients with high negative and positive symptoms. Cortical volume, thickness and gyrification were compared between subgroups using FreeSurfer software. Results showed that patients with high negative symptoms, compared to those with low negative symptoms, have decreased gyrification in the medial occipito-temporal (MOT) and lateral temporo-parietal (LTP) cortices of the left hemisphere, and in the medial temporal (MT)/posterior cingulate (PCC) cortices of the right hemisphere. These findings suggest that high negative symptoms are associated with gyrification reductions predominantly in medial occipital and temporal regions, which are areas implicated in social cognition and early visual processing. Furthermore, as cortical folding develops in utero and during the first years of life, reduced gyrification may represent an early biomarker predicting the development of negative symptoms.

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“…While there evidence of a strong association between negative symptoms and objective quality of life (OQOL) (Ho et al, 1998;Hunter and Barry, 2012;Milev et al, 2005;Whitty et al, 2008), only a weak association between negative symptoms and subjective quality of life (SQOL) has previously been found (Eack and Newhill, 2007;Fitzgerald et al, 2001;Narvaez et al, 2008;Priebe et al, 2011). This may be because SQOL is determined by multiple processes, including the comparison between expectations and aspirations, a comparison with others, and adaptation over time, all of which may result in a less negative appraisal by individuals with chronic schizophrenia (Priebe, 2007).…”

Section: Introductionmentioning

confidence: 99%

The relationship between experiential deficits of negative symptoms and subjective quality of life in schizophrenia

Savill

Orfanos

Reininghaus

et al. 2016

Schizophrenia Research

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Predictive Values of Neurocognition and Negative Symptoms on Functional Outcome in Schizophrenia: A Longitudinal First-Episode Study With 7-Year Follow-Up

Cited by 816 publications

References 38 publications

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

Morphological brain changes associated with negative symptoms in patients with 22q11.2 Deletion Syndrome

The relationship between experiential deficits of negative symptoms and subjective quality of life in schizophrenia

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