Predictive value of vaginal IL-6 and TNFα bedside tests repeated until delivery for the prediction of maternal-fetal infection in cases of premature rupture of membranes

Kayem, Gilles; Batteux, Frédéric; Girard, Noémie; Schmitz, Thomas; Willaime, Marion; Maillard, Florie; Jarreau, Pierre Henri; Goffinet, François

doi:10.1016/j.ejogrb.2017.01.013

Cited by 16 publications

(22 citation statements)

References 31 publications

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“…Of note is the performance of the Chorioquick test in triple positive results which could be beneficial in obstetric practice: when the combined tests were all positive, the specificity and PPVs were 100.0% in all categories of women in all gestations. These predictive values were superior to what were reported in previous studies …”

Section: Discussioncontrasting

confidence: 86%

“…did not show any association between clinical chorioamnionitis and IL‐6 in vaginal secretions. The observation in this study of improved diagnostic value of the Chorioquick test at term gestation compared with previous studies provides important proof‐of‐principle for translational innovation in Chorioquick testing.…”

Section: Discussionmentioning

confidence: 51%

“…The present study predicted histologically confirmed chorioamnionitis using the Chorioquick test, which was in line with criteria used in previous studies. 4,17,21 Compared to binary tests used in previous studies, the scientific evidence to assume that the semi-quantitative IL-6 marker in Chorioquick would be a good test to diagnose sub-clinical In conclusion, the present study-the first into the Chorioquick test-showed favorable utility for detecting chorioamnionitis in PROM and could be a more reliable, non-invasive rapid tool in a realworld clinical setting, especially for those with some degree of acute chorioamnionitis. To our knowledge, this was the first time that a semi-quantitative bedside test has been used to evaluate IL-6 from cervicovaginal secretions in women with PROM.…”

Section: Discussionmentioning

confidence: 71%

“…These predictive values were superior to what were reported in previous studies. [20][21][22][23][24][25] Chorioquick and histological chorioamnionitis were only discordant in five (6.8%) cases, while Chorioquick and clinical chorioamnionitis were discordant in 20 (27.4%) cases at repeated assessments. Thus, it could be concluded that a significant association exists between women who tested positive for Chorioquick and neonatal admission of the infant to the NICU.…”

Section: Discussionmentioning

confidence: 97%

“…The main strengths of the present study were its double‐blind design (to both histopathologist and patient). The present study predicted histologically confirmed chorioamnionitis using the Chorioquick test, which was in line with criteria used in previous studies . Compared to binary tests used in previous studies, the scientific evidence to assume that the semi‐quantitative IL‐6 marker in Chorioquick would be a good test to diagnose sub‐clinical chorioamnionitis was that the usage of the three thresholds ensured stratification performances of the different profiles, since the triple negative had an NPV of 96.7% while PPV of the triple positive was 100.0%.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic value of Chorioquick for detecting chorioamnionitis in women with premature rupture of membranes

Eleje

Ukah

Onyiaorah

et al. 2020

Intl J Gynecology & Obste

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Objective To determine the accuracy of a semi‐quantitative interleukin‐6 (IL‐6) vaginal secretion rapid test (Chorioquick) for detecting chorioamnionitis in women with premature rupture of membranes (PROM). Methods A prospective cohort study in five tertiary hospitals in Nigeria involved women with confirmed PROM at term and preterm PROM with or without suspected chorioamnionitis from August 1, 2017, to October 31, 2018. Cervicovaginal fluid samples were tested for chorioamnionitis using the Chorioquick test. Samples were repeated at decision to deliver. The test was considered positive if at least the indicator ‘IL‐6 low’ of the three Chorioquick biomarkers (low, medium, high) was positive, or negative if none of the biomarkers were positive. Chorioamnionitis was histologically confirmed post‐delivery using three tissue samples. Primary outcome measures were sensitivity, specificity, and accuracy. Results Of 73 women, on histological confirmation, 39 were true positive and 29 were true negative (for chorioamnionitis) to the Chorioquick test at repeat assessment. Overall, the Chorioquick test had a sensitivity of 97.5% (95% confidence interval [CI] 85.3–99.9), specificity 87.9% (70.9–96.0), and accuracy 93.2% (79.5–99.1). Sub‐group analysis of women <37 weeks of pregnancy showed a sensitivity of 100.0% (95% CI 83.4–100.0), specificity of 91.3% (70.5–98.5), and accuracy of 95.8% (82.5–99.5). Triple positive samples were 100.0% specific in all gestations. Conclusion Chorioquick showed favorable utility for detecting chorioamnionitis in PROM and could be a reliable, non‐invasive rapid tool in a real‐world clinical setting.

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Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Diagnostic value of Chorioquick for detecting chorioamnionitis in women with premature rupture of membranes

Eleje

Ukah

Onyiaorah

et al. 2020

Intl J Gynecology & Obste

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The significance of TNF‐α and MMP‐8 concentrations in non‐invasively obtained amniotic fluid predicting fetal inflammatory response syndrome

Gulbiniene

Balciuniene

Dumalakienė

et al. 2022

Intl J Gynecology & Obste

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Objective: To determine the significance of tumor necrosis factorα (TNFα) and matrix metalloproteinase-8 (MMP-8) in vaginally obtained amniotic fluid predicting fetal inflammatory response syndrome (FIRS) after preterm premature rupture of membranes (PPROM). Methods:In this prospective case-control study, TNFα and MMP-8 concentrations were evaluated in vaginally obtained amniotic fluid from women with PPROM at 22-34 weeks of pregnancy. Biomarkers' concentrations were determined using an enzyme-linked immunosorbent assay. Patients were divided into two groups: the FIRS group (cord blood interleukin-6 > 11 pg/ml or histological funisitis) and the non-FIRS group (without these findings). The data were analyzed using R package (R-4.0.5). Results:The median TNFα and MMP-8 concentrations in amniotic fluid from the 145 women included in the study were higher in the FIRS group than in the non-FIRS group. The area under the curve of TNFα and MMP-8 was 0.77 and 0.75, respectively. The TNFα concentration cut-off predicting FIRS was 89.20 pg/ml and was 170.76 pg/ml for MMP-8. In regression analysis, MMP-8 concentration was an independent predictor for FIRS. An MMP-8 concentration greater than 170 ng/ml and a TNFα concentration greater than 89 pg/ml increased the odds of FIRS 7.62 and 14.92 times, respectively.Conclusions: MMP-8 and TNFα concentrations in vaginally obtained amniotic fluid may be good predictors for FIRS after PPROM before 34 weeks of pregnancy.The non-invasive amniotic fluid analysis could be an alternative method to invasive amniocentesis. K E Y W O R D S amniotic fluid, biomarker, fetal inflammatory response syndrome (FIRS), matrix metalloproteinase-8 (MMP-8), non-invasive method, preterm birth, preterm premature rupture of membranes (PPROM), tumor necrosis factorα (TNFα) How to cite this article: Gulbiniene V, Balciuniene G, Dumalakiene I, Viliene R, Pilypiene I, Ramasauskaite D. The significance of TNF-α and MMP-8 concentrations in non-invasively obtained amniotic fluid predicting fetal inflammatory response syndrome.

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Amnioninfektionssyndrom oder Triple I

Zöllkau,

Pastuschek,

Schleußner

2024

Gynäkologie

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Predictive value of vaginal IL-6 and TNFα bedside tests repeated until delivery for the prediction of maternal-fetal infection in cases of premature rupture of membranes

Abstract: The association of vaginal cytokines with maternal-fetal infection is weak and thus prevents their use as a good predictor of maternal-fetal infection. CRP and vaginal samples may be useful for identifying a group of women at low risk of infection.

Cited by 16 publications

References 31 publications

Diagnostic value of Chorioquick for detecting chorioamnionitis in women with premature rupture of membranes

Diagnostic value of Chorioquick for detecting chorioamnionitis in women with premature rupture of membranes

The significance of TNF‐α and MMP‐8 concentrations in non‐invasively obtained amniotic fluid predicting fetal inflammatory response syndrome

Amnioninfektionssyndrom oder Triple I

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