Predictive value of tumor markers in patients with recurrent hepatocellular carcinoma in different vascular invasion pattern

Gao, Feng; Zhu, Heng-Kai; Zhu, Yang-Bo; Shan, Qiaonan; Ling, Qi; Wei, Xuyong; Xie, Haiyang; Zhou, Lin; Xu, Xiao; Zheng, Shusen

doi:10.1016/s1499-3872(16)60095-4

Cited by 21 publications

(13 citation statements)

References 28 publications

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“…Besides liver cancer, malignant tumors from stomach, pancreas, and reproductive system are often accompanied by a small amount of increased AFP. In general, AFP is produced only at low levels after birth; however, majority of human HCC overexpress high level of AFP in eastern populations [ 6 , 7 ]. Therefore, the HCC patients with AFP negative or weak positive in serum is usually consistent with the characteristics of high differentiated cancers [ 6 , 7 ].…”

Section: Significance Of Alpha-fetoprotein Expression In Hepatocelmentioning

confidence: 99%

“…Due to the insidious onset and long incubation period of HCC, patients usually got intermediate or advanced stage with poor prognosis. At present, the treatments of liver cancer mainly rely on surgical resection, liver transplantation, local ablation, chemoembolization, and molecular targeted therapy, but the effects of these strategies are not ideal and the mortality is still high [ 5 , 6 ]. Therefore, there is an urgent need to develop effective adjuvant therapies that may prolong the life and improve the quality of patients with HCC.…”

Section: Introductionmentioning

confidence: 99%

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Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity

Wang

2018

Canadian Journal of Gastroenterology and Hepatology

109

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Hepatocarcinoma is one of the most prevalent gastroenterological cancers in the world with less effective therapy. As an oncofetal antigen and diagnostic marker for liver cancer, alpha-fetoprotein (AFP) possesses a variety of biological functions. Except for its diagnosis in liver cancer, AFP has become a target for liver cancer immunotherapy. Although the immunogenicity of AFP is weak and it could induce the immune escapes through inhibiting the function of dendritic cells, natural killer cells, and T lymphocytes, AFP has attracted more attention in liver cancer immunotherapy. By in vitro modification, the immunogenicity and immune response of AFP could be enhanced. AFP-modified immune cell vaccine or peptide vaccine has displayed the specific antitumor immunity against AFP-positive tumor cells and laid a better foundation for the immunotherapy of liver cancer.

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Section: Significance Of Alpha-fetoprotein Expression In Hepatocelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity

Wang

2018

Canadian Journal of Gastroenterology and Hepatology

109

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“…Hepatocellular carcinoma (HCC) with approximately 600,000 newly diagnosed cases every year is the most common primary liver cancer (Ganne‐Carrie & Nahon, 2019; Chen & Zhang, 2011). Current treatments for HCC include surgical resection, local ablation, chemoembolization, liver transplantation, and molecular targeted therapy (Gao, Zhu et al, 2016; Mizejewski, 2016). Although these treatments improve the survival of patients with HCC to some extent, high mortality still exists.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐214‐3p enhances erastin‐induced ferroptosis by targeting ATF4 in hepatoma cells

Bai

Liang

Zhu

et al. 2020

Journal Cellular Physiology

Self Cite

102

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Primary liver cancer is the second most frequent cause of cancer‐related deaths. Ferroptosis, a recognized form of regulated cell death, recently gains attention. MicroRNA‐214‐3p (miR‐214) plays a regulatory role in hepatocarcinogenesis. However, the role of miR‐214 in cellular ferroptosis is unclear. This study aimed at elucidating whether miR‐214 could regulate ferroptosis of liver cancer. In vitro, HepG2 and Hep3B cancer cells were treated with erastin, a ferroptosis inducer, and then erastin was demonstrated to suppress the cell viability. Moreover, pre‐miR‐214 overexpression caused that HepG2 and Hep3B cells were more susceptible to erastin, whereas anti‐miR‐214 sponge showed the opposite effect. Additionally, pre‐miR‐214 overexpression increased the malondialdehyde and reactive oxygen species levels, upregulated Fe2+ concentration, and decreased glutathione levels in cancer cells exposed to erastin. Further, erastin enhanced the activation of transcription factor 4 (ATF4) in HepG2 and Hep3B cells, and pre‐miR‐214 overexpression inhibited ATF4 expression. The luciferase reporter data validated ATF4 as a direct target of miR‐214. Cancer cells transfected with ATF4 overexpression plasmid rendered lower susceptible to miR‐214‐induced ferroptotic death. In vivo, erastin significantly reduced the size and weight of xenografted tumors, and miR‐214 elevated the ferroptosis‐promoting effects of erastin and decreased ATF4 expression. In summary, our study demonstrates that the ferroptosis‐promoting effects of miR‐214 in hepatoma cells are attributed at least to its inhibitory effects on ATF4, which may provide a new target for therapy of hepatoma regarding ferroptosis.

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“…AFP is a glycoprotein derived from embryonic endoderm tissue cells. Serum AFP level in the fetus is high and decreases gradually after birth to the level of adults mainly due to the loss of the ability of mature hepatocytes to synthesize AFP, however, liver cancer cells can regain the ability to synthesize AFP and this can explain the elevation of its level in sera of HCC patients [26,27] .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Basic Fibroblast Growth Factor and Platelet-Derived Growth Factor-AB Circulating Levels in Hepatitis C Virus-Associated Hepatocellular Carcinoma

Azm

Ibrahim²

2020

The Medical Journal of Cairo University

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Background: As a hypervascular tumor, Hepatocellular Carcinoma (HCC) is characterized by neovascularization which plays an important role in its growth and progression. Basic Fibroblast Growth Factor (bFGF) is a potent endothelial cell mitogen and angiogenic factor that was found to be elevated in different cancers. Platelet-Derived Growth Factor-AB (PDGF-AB) is another factor implicated in enhanced proliferation and migration of pericytes and is a potent stimulator of angiogenesis in many tumors. Aim of Study:This study aimed to evaluate the circulating levels of bFGF and PDGF-AB and to examine their diagnostic significance in Hepatitis C Virus (HCV)-associated HCC.Methods: This study included one hundred subjects divided into healthy controls (n=25), HCV patients (n=25), and HCVassociated HCC patients (n=50). The levels of bFGF, PDGF-AB, and Alpha-Fetoprotein (AFP) in addition to the activities of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase as well as total bilirubin and albumin concentrations were determined in sera of the enrolled subjects.Results: Levels of bFGF and PDGF-AB were higher in HCC patients compared to controls and HCV patients and were found to be associated with increased susceptibility to HCV-associated HCC. Additionally, the diagnostic values of bFGF and PDGF-AB to distinguish HCC patients from noncancerous patients were good, although they are still inferior to that of AFP. However, the combination of bFGF and PDGF-AB with AFP enhanced the efficacy of the latter. Conclusion:Serum bFGF and PDGF-AB may contribute to the pathogenesis of HCV-associated HCC, and they seem to be good diagnostic biomarkers of HCC along with AFP.

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Predictive value of tumor markers in patients with recurrent hepatocellular carcinoma in different vascular invasion pattern

Cited by 21 publications

References 28 publications

Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity

Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity

MicroRNA‐214‐3p enhances erastin‐induced ferroptosis by targeting ATF4 in hepatoma cells

Diagnostic Value of Basic Fibroblast Growth Factor and Platelet-Derived Growth Factor-AB Circulating Levels in Hepatitis C Virus-Associated Hepatocellular Carcinoma

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