Predictive value of triglycerides to high-density lipoprotein cholesterol and triglyceride glycemic index for diabetes incidence in pre-diabetes patients: a prospective cohort study

Sharafi, Mehdi; Amiri, Zahra; Pezeshki, Babak; Mohsenpour, Mohammad Ali; Eftekhari, Mohammad Hassan; Afrashteh, Sima; Haghjoo, Elham; Farhadi, Akram; Khaleghi, Mohsen; Mastaneh, Zahra

doi:10.1186/s41043-023-00410-5

Cited by 5 publications

(1 citation statement)

References 34 publications

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“…Independently, a recent prospective study demonstrated a clear relationship between elevated TG/HDL levels (as well as elevated triglyceride/glucose index) and insulin resistance as a predictor of progression from prediabetes to diabetes. 29 This finding is of value because a meta-analysis indicated the high frequency of new-onset diabetes in long-COVID-19 patients, with risks ranging from 11% to 276% compared with patients. 30 Further research is needed to explain why only 3.5% of all potential patients with a potential worsening insulin resistance after COVID-19 develop IST.…”

Section: Discussionmentioning

confidence: 96%

Triglicerydes/high‐density lipoprotein ratio as a risk factor of post‐Covid‐19 sinus tachycardia: A retrospective study

Kuryłowicz,

Babicki,

Wąsowski

et al. 2024

Journal of Medical Virology

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Inappropriate sinus tachycardia (IST) is one of the manifestations of the post‐COVID‐19 syndrome (PCS), which pathogenesis remains largely unknown. This study aimed to identify potential risk factors for IST in individuals with PCS. The 1349 patients with PCS were included into the study. Clinical examination, 24H Holter ECG, 24H ambulatory blood pressure monitoring and biochemical tests were performed 12–16 weeks after the COVID‐19 in all participants. IST was found in 69 (3.5%) individuals. In the clinical assessment IST patients were characterized by a higher age (p < 0.001) and lower prevalence of the diagnosed hypertension (p = 0.012), compared to remaining patients. Biochemical testing showed higher serum triglycerides (1.66 vs. 1.31 pmol/L, p = 0.007) and higher prevalence of a low high‐density lipoprotein (HDL) cholesterol (24.6% vs. 15.2%, p = 0.035) in the IST group. Subsequently, the triglicerydes (TG)/HDL ratio, an indicator of insulin resistance, was significantly higher in the IST individuals (3.2 vs. 2.4, p = 0.005). 24H monitoring revealed a significantly higher minimum diastolic, maximum systolic and mean arterial blood pressure values in the IST group (p < 0.001 for all), suggesting a high prevalence of undiagnosed hypertension. A multivariate analysis confirmed the predictive value TG/HDL ratio >3 (OR 2.67, p < 0.001) as predictors of IST development. A receiver operating characteristic curve analysis of the relationship between the TG/HDL ratio and the IST risk showed that the predictive cut‐off point for this parameter was 2.46 (area under the ROC curve = 0.600, p = 0.004). Based on these findings, one can conclude that insulin resistance seems to be a risk factor of IST, a common component of PCS.

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Section: Discussionmentioning

confidence: 96%

Triglicerydes/high‐density lipoprotein ratio as a risk factor of post‐Covid‐19 sinus tachycardia: A retrospective study

Kuryłowicz,

Babicki,

Wąsowski

et al. 2024

Journal of Medical Virology

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Associations of triglyceride–glucose index cumulative exposure and variability with the transitions from normoglycaemia to prediabetes and prediabetes to diabetes: Insights from a cohort study

Wang,

Liu,

Yang

et al. 2024

Diabetes Research and Clinical Practice

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Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults

Zheng

Zhang²,

Han

et al. 2023

Cardiovasc Diabetol

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Background The atherogenic index of plasma (AIP) can reflect the burden of atherosclerosis. Hyperglycemia is one of the leading causes of atherosclerosis. However, the relationship between AIP and prediabetes is rarely studied. Therefore, we aimed to explore the relationship between AIP and prediabetes. Methods This retrospective cohort study recruited 100,069 Chinese adults at the Rich Healthcare Group from 2010 to 2016. AIP was calculated according to Log10 (triglyceride/high-density lipoprotein cholesterol) formula. Cox regression method, sensitivity analyses and subgroup analyses were used to examine the relationship between AIP and prediabetes. Cox proportional hazards regression with cubic spline functions and smooth curve fitting was performed to explore the non-linearity between AIP and prediabetes. The two-piece Cox proportional hazards regression model was used to determine the inflection point of AIP on the risk of prediabetes. Results After adjusting for confounding covariates, AIP was positively associated with prediabetes (HR: 1.41, 95%CI: 1.31–1.52, P < 0.0001). The two-piecewise Cox proportional hazards regression model discovered that the AIP’s inflection point was 0.03 (P for log-likelihood ratio test < 0.001). AIP was positively associated with the risk of prediabetes when AIP ≤ 0.03 (HR: 1.90, 95%CI: 1.66–2.16, P < 0.0001). In contrast, When AIP > 0.03, their association was not significant (HR: 1.04, 95%CI: 0.91–1.19, P = 0.5528). Conclusion This study shows that AIP was positively and non-linearly associated with the risk of prediabetes after adjusting for other confounding factors. When AIP ≤ 0.03, AIP was positively associated with the risk of prediabetes.

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Predictive value of triglycerides to high-density lipoprotein cholesterol and triglyceride glycemic index for diabetes incidence in pre-diabetes patients: a prospective cohort study

Cited by 5 publications

References 34 publications

Triglicerydes/high‐density lipoprotein ratio as a risk factor of post‐Covid‐19 sinus tachycardia: A retrospective study

Triglicerydes/high‐density lipoprotein ratio as a risk factor of post‐Covid‐19 sinus tachycardia: A retrospective study

Associations of triglyceride–glucose index cumulative exposure and variability with the transitions from normoglycaemia to prediabetes and prediabetes to diabetes: Insights from a cohort study

Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults

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